Join Us

We are 216,681 members in 84 forums discussing 160,146 topics.

Help with Abbreviations

Topic: pCR for HER2+ (Positive) Breast Cancer

Forum: HER2+ (Positive) Breast Cancer —

Testing, treatment, side effects, and more.

Posted on: Apr 5, 2019 10:37AM - edited Apr 5, 2019 10:38AM by LilyCh

LilyCh wrote:

One of the MOs once mentioned that for HER2+ cancer after NAC, the pCR rate for ER+ is much lower than that for ER- (~30% vs ~70%?). Wondering if that is the case, would you mind sharing your ER status (and number) for those of you who did or did not achieve pCR?

LilyCh: No pCR, ER+(70%)PR+(70)HER2+


My question is, if it is harder for ER+ to achieve pCR, why not add hormonal therapy during the NAC?

Dx 6/5/2018, IDC, Right, 2cm, Stage IA, Grade 2, ER+/PR+, HER2+ (IHC) Chemotherapy 7/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 7/12/2018 Perjeta (pertuzumab) Targeted Therapy 7/12/2018 Herceptin (trastuzumab) Surgery 11/21/2018 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy 1/14/2019 Whole-breast: Breast Hormonal Therapy 3/12/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
Log in to post a reply

Page 1 of 1 (13 results)

Posts 1 - 13 (13 total)

Log in to post a reply

May 7, 2019 06:39PM Sunocean wrote:

hi. I achieved pcr. But I'm ER and Pr negative.

Dx 9/5/2018, DCIS/IDC, Right, 4cm, Grade 3, ER-/PR-, HER2+ (IHC) Chemotherapy 9/18/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 9/18/2018 Perjeta (pertuzumab) Targeted Therapy 9/18/2018 Herceptin (trastuzumab) Surgery 2/15/2019 Mastectomy: Right; Prophylactic mastectomy: Left Surgery 2/15/2019 Lymph node removal: Right, Underarm/Axillary Radiation Therapy 4/3/2019 Whole-breast: Lymph nodes, Chest wall
Log in to post a reply

May 11, 2019 05:02PM rozem wrote:

hi there.

I had PCR and was highly ER and PR positive. I believe over 90% ( it’s been almost 8 years so the % are a bit fuzzy!)

I was told that this was more common with hormone Neg Her2 positive cancers. Perhaps my grade 3 cancer behaved more like hormone negative and responded very well to chemo




FEC-DH, LUMP, 25 RADS, TAMOX, BMSX with LD flap (worst surgery ever) Dx 8/2011, IDC, 2cm, Stage IIA, Grade 3, 0/2 nodes, ER+/PR+, HER2+
Log in to post a reply

May 12, 2019 12:37AM - edited May 12, 2019 12:38AM by Gudrun

Dear Lily,

my daughter didn't achieve pcr either. I feel your disappointment. Her tumor was also highly ER and PR positive. Her Ki67 had fallen from 20% to 2%, which she was told was an excellent predictive indicator.

best wishes, G

Myself: dx at 55 in 2013, ILC, stage IIa, G2, ER+/PR-/HER2-, KI67 20%, BMX, Letrozole 5.5 years. Daughter: dx at 28, stopped antihormonals after 2 years to have a baby and restart tx afterwards: Dx 8/2015, IDC, Left, 3cm, Stage IIA, Grade 2, 0/4 nodes, ER+/PR+, HER2+ (IHC) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone), Zoladex (goserelin) Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab) Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery Mastectomy: Left; Reconstruction (left): TUG flap
Log in to post a reply

Jun 18, 2019 11:12AM MissouriCatLady wrote:

I achieved pcr. I am ER positive PR negative.

diagnosed at 55, DX 10/17/18 IDC Left IIB grade 3 0/2 nodes ER+PR-HER2+, 11/7/18 TCHP, 4/4/19 Left Lumpectomy, 4/29/19 anastrozole (name-brand at CVS with a GoodRX coupon), 6/3/19 Rads, HP done 1/8/20, complete response to neoadjuvant therapy
Log in to post a reply

Jun 18, 2019 12:42PM el7277 wrote:

I am 40 % Er + and did not achieve pCR although my MO and BS could not feel any palpable mass. I had residual cancer in the tumor bed. My tumor was 1.7 cm and I had 7 mm of residual disease. I am low Ki67 and 5% PR +.

I had bmx and am going for second round of Kadcyla tomorrrow.

Dx 12/3/2018, IDC, Right, 1cm, Stage IA, Grade 2, 0/3 nodes, ER+/PR+, HER2+ Targeted Therapy 12/19/2018 Herceptin (trastuzumab) Surgery 4/25/2019 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy Carboplatin (Paraplatin), Taxotere (docetaxel)
Log in to post a reply

Jul 2, 2019 11:48PM - edited Jul 2, 2019 11:49PM by WC3

LilyCh:

My cancer was 90% ER+/PR+ and I had a pCR but still had DCIS remaining.


Dx 2018, IDC, Left, 3cm, Grade 3, ER+/PR+, HER2+ (FISH) Chemotherapy 5/31/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Surgery 11/14/2018 Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Targeted Therapy Perjeta (pertuzumab) Targeted Therapy Herceptin (trastuzumab) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
Log in to post a reply

Sep 8, 2019 10:07AM Hurcheon wrote:

I acheived pCR was Stage 3c and Pr and Er+ (7/8).

Log in to post a reply

Sep 19, 2019 02:25PM rajae wrote:

LilyCh


hi! i had the same question as you. did you have an answer?

Log in to post a reply

Sep 19, 2019 06:55PM - edited Oct 4, 2019 05:57PM by LilyCh

rajae, I did ask the MO and she said hormonal therapy will interfere chemo and they should not be used together.

Dx 6/5/2018, IDC, Right, 2cm, Stage IA, Grade 2, ER+/PR+, HER2+ (IHC) Chemotherapy 7/12/2018 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy 7/12/2018 Perjeta (pertuzumab) Targeted Therapy 7/12/2018 Herceptin (trastuzumab) Surgery 11/21/2018 Lumpectomy: Right; Lymph node removal: Sentinel Radiation Therapy 1/14/2019 Whole-breast: Breast Hormonal Therapy 3/12/2019 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
Log in to post a reply

Oct 4, 2019 01:42PM Kimm992 wrote:

I am hormone negative and had an ALMOST pCR. The surgeon found only tiny "spatters" of cancer cells left at time of surgery which he said was a good indicator that the chemo did it's work.

Dx 10/14/2015, IDC, Right, 1cm, Grade 3, 0/3 nodes, ER-/PR-, HER2+ Chemotherapy 11/2/2015 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Targeted Therapy 1/6/2016 Herceptin (trastuzumab) Chemotherapy 1/7/2016 Taxotere (docetaxel) Surgery 3/24/2016 Mastectomy: Right Radiation Therapy 4/30/2016 Lymph nodes, Chest wall
Log in to post a reply

Oct 8, 2019 09:08PM Honeybee68 wrote:

I am ER/PR negative and HER2 positive, Stage IV. I achieved a PCR. I had a lumpectomy and 6 lymph nodes removed. The surgeon said there were no cancer cells remaining when they looked at the specimens under the microscope. The two liver mets shrunk and what is left they believe is scar tissue because they don't take up any of the radioactive sugar on PET scan.
Dx age 49, 06/06/18, stage IV DCIS and IDC, ER-, PR-, HER2+, 2 liver mets, 07/20/2018, Taxol weekly 4 mos, Herceptin & Perjeta indefinitely. Two site lumpectomy and lymph node biopsy, 0/6 nodes 04/15/19. Whole breast radiation starting 05/13/19.
Log in to post a reply

Oct 15, 2019 11:31PM IdRatherBeBoatin wrote:

I achieved pCR after TCHP chemo. I was stage 2A, no node involvement. Did a BMx with expanders. Exchange surgery next month. Glad to be on the down slope!

Dx 1/22/2019, IDC, Right, 2cm, Grade 3, ER-/PR-, HER2+ (FISH) Targeted Therapy 2/5/2019 Herceptin (trastuzumab) Chemotherapy 2/6/2019 Carboplatin (Paraplatin), Taxotere (docetaxel) Targeted Therapy Perjeta (pertuzumab)
Log in to post a reply

Oct 17, 2019 02:33PM Margun wrote:

LdRather- if you have no lymph nod involvement then you are not having radiotherapy?

Page 1 of 1 (13 results)