Best Of

Hi @mommacj,

I thought I'd chime in about Bria-IMT. Somewhere around page 145 I posted about it.

I was on the trial in October 2024. I was in the vaccine only arm but progressed after the first round, so they switched me to the arm with the checkpoint inhibitor. I progressed again, so I went off the trial. The doctor said since my TMB was 5 and my PDL1 negative I would probably progress again, so those are two important factors. The higher the TMB the better and PDL1 positive makes a difference too. I'm not sure why they bothered to put me on it if that was the case to begin with, but I suspect they care more about their trials than the subjects. At least at that facility.

But the good news is I think it slowed it down some and also helped raise my TMB. It's now almost 15 which I believe opens up immunology options for me.

The other options you have sound interesting if your TMB/PDL1 aren't suited for IMT.

Good luck deciding and wish you the best!

CBL

Hi everyone, it's been a while since I've posted but I check in often to see how everyone is doing and the news on this thread. I completely agree CBL knowledge is power and I am grateful for all of the experience in trials and treatments you bring to this thread. @cure-ious thank you for all of the clinical news and updates. I've been on Xeloda since the end of last September. I really love that drug but it doesn't love me anymore. I am really sad to move on. I don't know if you remember but I was in a very bad way Christmas of 2023 and in the hospital on oxygen after afinitor gave me a bad case of pneumonitis. I was off treatment and had major progression. Truqap helped settle things down but was short lived and then Xeloda cleared all of my liver mets and all of my bones mets and pelvis mets but one single met in my T9. So we used proton radiation to try and achieve NEAD but the Xeloda has stopped working. My scans showed numerous liver lesions up to about 25% of my liver, and many bones in my spine, pelvis, and hips. So my cancer got aggressive and angry. My primary onc saw me yesterday and suggested Trodelvy and looking into a trial possibly. I wanted to try the new triplet combo with ibrance and itovebi but she thought it was risky. On my last Caris report a year ago when I started Xeloda I still had the pik3 mutation but she said we didn't have time to biopsy and wait and see if it's still there and that Trodelvy covered all the bases even if my cancer mutated. She was also leaving the country to India that afternoon because her father is ill so we didn't have a lot of time to talk. I have a second opinion oncologist at UCLA and she sent me 3 trial options that we will discuss tomorrow. I am limited with trials now due to my grade 3 pneumonitis history although it's since resolved and my lungs are doing very well. One trial she mentioned is Bria Cell IMT. There are two other trials that seem very interesting. One is RYZ101-2011 (aka TRACY-1) trial. The other is Radionetic R10602. They are radioligand trials -- basically you get a special PET/CT to find out if your cancer has a specific protein on the surface. If it does, you can receive an infusion of a medication with a little bit of radioactive material attached to bind to that protein. It seems to be very new in Breast cancer trials but when I tried to search a little it looks like they've done it in prostate cancer. So I am very curious about it and hoping it might be something promising. Just wondering if anyone has heard anything about radioligand treatment and/or experience with Bria cell IMT?

Sorry to read that we have lost Kris/KBL, yet another caring and strong sister in this community. She was such a huge part of the caring support around BCO and I loudly echo what others have said about her here. I actually had written about her in my gratitude journal this week, before seeing this notice. Definitely one of the people I most appreciated on this board.

Sincere condolences and gentle hugs to Kris’s family.

@kbl Kris will be deeply missed and always held in our hearts. She was such a brave, generous, and supportive presence here.

So grateful to have “known” kbl through this forum and for the valuable discussions she started and participated in. ❤️

After these months of right hip problems, my poor left leg developed something this week. I got an x-ray-supposedly nothing's wrong but it hurt for a few days to bear weight and I had to use a cane to walk. But I was able to get in the pool today for water aerobics. Felt really good to move. I'm a little sore now but it's a good sore.

Hi everyone, we are so sad to report @kbl 's sister posted this morning that she passed last evening. As with each loss, we are so saddened to have to share this news with you and hold everyone who loved Kris in our hearts while we grieve along with you. Kris was so loved here, contributing and caring so much, and will be deeply missed.

Sending gentle hugs,

—The Mods

I’m sad to hear about kbl. She was someone who helped me see light through the dark days when I was first diagnosed. My thoughts are with her family and friends.

Thank you to the rest of you who continue to post and give me hope.