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You can go on an oral bisphosphonate like Fosamax instead. The "bone marker" test probably being referred to is N-Telopeptide (NTx), a urine test that monitors changes in fragments of type 1 collagen showing how well the med is working. Whenever I have to go back on Fosamax due to the results of a DEXA scan my endo orders the urine test to monitor what is happening.

It might be worth seeing an endocrinologist who does this regularly for patients with osteoporosis to supervise the transition and monitor your bone health. An oral med like Fosamax clears your system much more quickly for invasive dental work than an infusion drug which stays in your system a long time. Having drug "holidays" (taking the med only when needed) is a good way to prevent ONJ.

Hello and Happy New Year ! I'm just checking in to say hello and ask if anyone has had any good results from hydrogen water? I keep reading so much about it and willing to try! Google AI summarizes much of what I have read:

Hydrogen water shows promise in animal studies for preventing bone loss by reducing oxidative stress and inflammation, potentially protecting against bone issues related to estrogen withdrawal or diabetes, and even showing anti-tumor effects in some cancer models, suggesting a role in managing bone conditions like osteoporosis and potentially supporting bone health during cancer treatment, though human research is limited. It acts as an antioxidant, reducing damaging reactive oxygen species (ROS) and inflammatory cytokines (IL-6, TNF-α) that harm bone.

How it Might Help Bone Health

• Reduces Oxidative Stress: Cancer and its treatments generate oxidative stress, which damages bone cells. Hydrogen water neutralizes these harmful molecules (ROS).
• Anti-inflammatory Properties: It suppresses pro-inflammatory signals (like IL-6 and TNF-α) that drive bone breakdown.
• Protects Bone Structure: In animal models, it prevented loss of bone mineral density and improved bone strength.
• Inhibits Osteoclast Activity: It can specifically reduce the activity of osteoclasts, the cells that break down bone. 

Relevance to Cancer & Bone Metastases

• General Anti-Cancer Effects: Hydrogen has shown anti-tumor effects, potentially slowing cancer progression and reducing side effects of chemotherapy.
• Support During Chemotherapy: It can mitigate chemotherapy side effects, improving liver function and reducing inflammation, which indirectly benefits overall health during cancer treatment.
• Bone Metastases (Early Research): While direct research on hydrogen water and established bone metastases (cancer spread to bone) is scarce, its effects on bone loss (osteopenia/osteoporosis) and cancer suggest it could be a supportive therapy, though this needs more study. 

Current Status

• Promising, but Early: Much evidence comes from animal studies, but results are encouraging for bone conditions and cancer side effects.
• Needs Human Trials: More extensive clinical trials in humans are needed to confirm benefits for bone metastases and establish clear protocols, notes this Frontiers article. 

In Summary: Hydrogen water shows potential as a complementary therapy by reducing inflammation and oxidative stress, which are key factors in bone loss and cancer progression, making it an interesting area for future research in managing bone metastases. 

I was mostly interested in trying for digestive reasons and my research brought up so much more. Just curious about others' experiences?!! Thanks and have a great day. Terry B.