Best Of

@intolight

So sorry about progression. Sending virtual hugs and prayers your way.

@mkestrel

Sympathize on the hair loss. It seems so cruel to have a side effect that makes our suffering public. My hair is very thin from 3.5 years of Kisqali. Would love to wear a wig, but afraid it would terrify my toddler grandchild who has only ever known me with thin hair. Cure-ious posted something on the Clinical Trial thread about UCLA and a serum for baldness. Wish they would hurry and get that approved! NYU Langone has published results of a study specifically on the successful use of oral Minoxidil by breast cancer patients.

@goldensrbest

Sending them your way now. I know how you feel - this disease has trained us all to expect the negative.

Please keep us posted.

💕

ACETABULUM - LABRUM

.@threetree Oh girly girl I’ve missed you. This has been a bad season for so many here. And you are very much like me in the way your bones and muscles react to barometric weather changes with in coming storms and temperature changes. Your new liver met diagnosis had t be a real emotional and strength draining occurrence, probably more than you realized. The stress of it would be normal to cause brain fog, and low energy like depression.. I too did also love the candle thing and I lit one last night inside my glow rock sea glass jar and it was so pretty and Ipeaceful even though the candle is a battery tea light candle. It made me feel very calm and connected to you all when I said a prayer while holding it. @threetree I too have not felt well since the summer with all the scans and tests and procedures for what they were finding on the scans, it was stressful and exhausting traveling back & forth to appointments and dealing with bronchoscope & pneumonia during the summer, going for the neck radio frequency Ablation procedure, and follow-ups and PT. Then my last scan showing the cause of the hip & groin pain was a new metastatic lesion on my Acetabulum. They sent me for 10 days of Palliative radiation to my hip & groin which has relieved the pain pretty much but my limping and mobility is still not great because I still have that lesion affecting my labrum which attaches to the Acetabulum rim of the hip where the ball and socket joint of the thigh bone fits. So the whole posterior acetabulum met involves my labrum & pubic bone and sacral illia in my low lumbar areal. With all this the Radiologist and neurologist want me to use a cane to keep from falling. Ughh cancer sucks 🤬.

@goldensrbest With all this hip pain and labrum stuff, I thought of you and what you ‘re going through. I wanted to understand every thing about my hip pain and my Acetablum metastatic new lesion. So I copied an article and pasted

👇

A metastatic lesion (cancer growth) on the acetabulum (hip socket) can damage the labrum by disrupting its attachment, causing inflammation, or directly eroding the cartilage, leading to tears (radial, flap) or detachment, which compromises joint stability, causes significant pain (groin, deep ache), and limits motion, potentially resulting in arthritis as the bone-on-bone friction increases.How it affects the labrum

• Direct Erosion/Damage: The metastatic tumor can grow into or destroy the labral tissue directly, leading to tears or significant loss of the labrum.
• Inflammation & Instability: The lesion causes inflammation and irritation, making the labrum weak and prone to tearing, similar to impingement, notes this article from HSS.
• Shearing Forces: If the lesion disrupts the normal hip mechanics, it creates abnormal forces (shearing) on the labrum, causing it to detach or fray, says this article from doldmd.com.
• Loss of Function: The labrum's role as a "gasket" for stability and smooth motion is lost, leading to clicking, catching, and pain, says this article from Orthopaedic Medical Group of Tampa Bay. 

Common labral issues from acetabular problems

• Tears: Radial flap tears (flap hangs loose) or longitudinal peripheral tears (along the rim) are common.
• Degeneration: Chronic irritation causes the labrum to fray and become "shaving brush" like (fibrillated).
• Ossification: In some cases, the damaged labrum can harden (ossify). 

Symptoms to watch for

• Deep groin pain, sharp pain with movement, clicking, catching, or a feeling of instability.
• Pain that can radiate to the lower back or leg. 

Key takeawayA metastatic lesion in the acetabulum is a serious structural problem that directly compromises the labrum, making labral tears and dysfunction a common, painful consequence, often requiring specialized management, as noted in this article from Annals of Jointand this article from the NIH. 

@mara51506 I’m glad you got some sleep……and your humidifier😉

@intolight Very sorry to hear about your progression. Prayers as you await your next steps.

@mkestrel Cancer sure sucks-diarrhea and hair loss! Ugh. Hang in there and dream about hiking in the Spring.

@goldensrbest Hope all turns out to be benign for your husband. I did have my hip replaced 10 weeks ago. It is so much better for me not to be in pain but I understand your reluctance to undergo a major operation.

I spoke with my oncologist last evening. She is recommending that I switch to Orserdu and Kisquali. The challenge may be getting the insurance company to approve both drugs. We'll see.

Best wishes to all. I brought my Christ candle out and put it in the window but usually don't light it until Christmas eve.