Best Of
Re: Alisertib clinical trial at Mayo
Hi @kiranabid and welcome to Breastcancer.org! We're so sorry for the reasons that bring you here, but we're really glad you've found us. You're sure to find our amazing community a wonderful source of advice, information, encouragement, and support — we're all here for you!
This post with lots of MBC resources will help you get started in finding threads that fit your needs and therefore others with whom you can share treatment experiences. There's also a handful of free, weekly virtual support groups we host for MBC folks, so we encourage you to check those out and join us face-to-face for support!
We hope you get some responses soon from others joining your trial so that you have a buddy or two! And sending best wishes to you for an excellent response to treatment — we're looking forward to following your experience.
Let us know if you need anything else at all, and thanks for posting!
—The Mods
Re: Aromatase inhibitors versus tamoxifen
I was put on 20mg tamoxifin after my active treatment finished. My Dr. said I could switch to an AI but after talking with people who have had bone issues on it, I asked to stay on tamoxifin. It's impossible to tell which of my side effects are menopause (tired, hot flashes, constipation) but overall, these effects are manageable and it has been ok for me. It was suggested to me to take it at night since it can make you tired and that's what I've done. Good luck with finding something that works better for you.
Re: Aromatase inhibitors versus tamoxifen
I have had next to no side effects from tamoxifen. Maybe slightly sluggish gastrointestinal tract but really nothing else. I think chemo put me into menopause so had some hot flushes from that but they settled down (I still feel warm generally but this now feels normal for me). No mood changes. I had quite bad insomnia following diagnosis but I think it was the shock as it has gradually improved. I work, bring up my children, clean the house, exercise daily and have plenty of energy for all of it.
My oncologist is rethinking his plan to switch me to an AI for my second five years of hormonal therapy. He certainly perceives AIs as less well tolerated than tamoxifen in general. And since I have been fortunate with tamoxifen, any side effects at all would be a backwards step. We are going to make a final decision in the coming year. He rolled his eyes when I asked him about all the side effects I'd read about here before I started it…
It breaks my heart when I read of women not even willing to try hormonal therapy. I am very grateful to live in a time when it exists.
Good luck with whatever you decide. It sounds like there is a good chance the tamoxifen will be an improvement for you.
Re: Aromatase inhibitors versus tamoxifen
After about 5 months Anastrozole made me very ill. Could not eat without feeling sick and things just hurt. Dr. even said things like , you will get used to it. They would not listen to me. The also ignored my swollen arm. After trying to work with them for almost 2 years with no improvement, I changed clinics. My new Dr. put me on Letrozole and sent me to a lymphoma Dr. for my arm. I am doing much better and am getting treatments for my arm. Delaying the move was detrimental and may even cost me years of survival. New Dr. considered my cancer aggressive since at a stage 1 in size it was already in my lymph nodes.
ask your Dr. about letrozole.
Re: Aromatase inhibitors versus tamoxifen
Unfortunately 40% of people are genetically predisposed to cartilage damage when taking AIs. That is what causes the joint pain. Stopping AIs doesn’t cure the damage but prevents it from getting worse.
Tamoxifen has its own set of side effects but cartilage damage isn’t one of them. People don’t get every side effect listed but things like increased chance of blood clots need to be considered with your medical history in mind.
It would be wonderful if there were an SE free option but that’s not the case. Good luck making the best decision for your situation.
Re: Contemplative practices - Affirmations, white light visualizations, healing meditations
@tougholdcrow, That makes sense. I think all are born with innate capabilities and one of the goals of our time here is to bring them out.

