ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM), and VUS (variants of unknown significance)
Hello, I was first diagnosed in 2015 with early stage IIb. I had genetic testing done at the time and was negative for all mutations including BRCA1 and 2. I had a recurrence in 2022 and I had the Caris test done on the tumor and again no BRCA found. Just within the last month I had a PET scan turn up some swollen lymph…
Hello I am new here, Our 45-year-old daughter died on May 14th of this year from triple negative breast cancer that metastasized to her brain and though a tumor was removed, it came back immediately and killed her. Unfortunately, family members knew back in 2020 that she should be tested for the RAD51D variant that had…
Hi, I keep reading studies online that refere to "brest cell lines", for example: MDA-MB-231, MDA-MB-468, MCF-7, and T-47D I can't understand what that really mean...if they actually matter, how do i know what cell line i have, if it is even important to know for the therapy choice. Do anybody know what I'm talking about…
Breast Cancer After Childbirth and Survival in Women With BRCA Mutation Jul 15, 2024 Does being diagnosed with breast cancer after giving birth affect survival? Read more…
Anyone with stage 1, grade 1 HR+, HER2- Invasive Ductal Carcinoma with a pathogenic BLM variant? Still waiting for final pathology after lumpectomy. With this genetic variant, a history of eczema & atopic dermatitis and numerous allergies, sensitive skin and hypermobility (connective tissue disorder), I am leaning towards…
Genetic Testing Saved My Life May 31, 2024 Dr. Brooklyn Olumba explains how discovering she had a BRCA2 mutation led to earlier breast cancer screening and detection. At the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, Dr. Brooklyn Olumba was part of ASCO Voices, a program that gives people in the…
Genetic Mutations More Likely in Breast Cancer Found Between Mammograms May 15, 2024 Having a family history of breast cancer and a mutation in any of the five main breast cancer genes may increase the chance that you may discover breast cancer between your routine mammograms. Read more…
Lynparza Approved To Treat High-Risk, Early-Stage, HER2-Negative Breast Cancer With BRCA Mutation Mar 13, 2022 The FDA approved Lynparza to treat early-stage, HER2-negative breast cancer with a BRCA1 or BRCA2 mutation and a high risk of recurrence, which also has been previously treated with chemotherapy — either before or…
ASCO and SSO Update Genetic Testing Guidelines for People With Breast Cancer Apr 8, 2024 Updated guidelines say anyone age 65 or younger diagnosed with breast cancer should have genetic testing for BRCA1 and BRCA2 mutations. Read more…
Hello, I was diagnosed with breast cancer at age 29. Genetic testing was brought up shortly after my diagnosis. I decided against it, at the time, for several reasons...the cancer institute in the city I live does not have a genetic counselor so I would have had to travel 5+ hours for this, no family history of breast…
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