Bottle o Tamoxifen
Comments
-
Hi LindaSue,
Just google grapefruit and tamoxifen - oodles of info!
0 -
Hi,
Re quinine and tonic water. Quinine is also on my list of things to avoid while on tamoxifen - as are anti-malarial drugs (like chloroquine). They inhibit the tamoxifen
I am so sorry - I feel like such a nay-sayer on this site.
I JUST WANT US ALL TO SUCCEED ON THIS WRETCHED DRUG (and unless we have as much info as we can get, we can't make informed decisions - even wrong ones)!!!!!!!
0 -
My Onc.NP just recommended the tonic water for leg cramps, which started this month and are a Tamox SE. Which I forgot to buy today anyway. I'll have to ask about the interaction. I'll have to try the bar of soap first - I thought that was for restless leg syndrome. Have a good week all.
0 -
...strange, but I have been getting leg cramps alot, too... wonder if it's the Tamoxifen? Some have been extremely painful.
Just popping in to say hi to all... and to add my countdown:
.... 26 more Tamoxifen pills...
Hugs to all
Harley
0 -
Grapefruit and Xanax another no no for the same reason, it slows down the metabolizism of Xanax and it can build up in your system.
I'm thinking we need to start a list of things we can do...
KarenW
0 -
bcamnb wrote: Re quinine and tonic water. Quinine is also on my list of things to avoid while on tamoxifen - as are anti-malarial drugs (like chloroquine). They inhibit the tamoxifen. I am so sorry - I feel like such a nay-sayer on this site.
Caroline - Actually, you're not "nay saying"(IMHO); you're raising an issue I hadn't considered. Although I certainly dont think any doctor knows everything, it hadn't occurred to me to check into my medonc's suggestion of using tonic water. I just thought, "Ok, easy solution; non drug; good" Now, because of your post, I'll take a little extra time and look it up. Whichever way I go it will be an informed decision rather one made out of complacency. That's a good thing ! Thank you.
0 -
Okay, I did some checking into Caroline's position and found an article, "Drug Interactions: Beware of CYP2D6 Inhibitors in Patients Taking Tamoxifen" http://www.pharmacytimes.com/issue/pharmacy/2009/2009-03/2009-03-10041 which did list Quinine as a CYP2D6 Inhibitor.
I also found an article that, while it states that while Quinine is a moderate CYP2D6 inhibitor, also expressly excludes Tamoxifen: "CYP2D6 substrates: CYP2D6 Inhibitors (Moderate) may decrease the metabolism of CYP2D6 Substrates. Exceptions: Tamoxifen. Risk C: Monitor therapy" http://www.merck.com/mmpe/print/lexicomp/quinine.html
While I'm still researching, I personally am keeping in mind that medical Quinine is considerably stronger that the Quinine in tonic water. For me, I'm thinking it's analogous to the soy in soy supplements vs soy sauce. While almost all ER + women are told to avoid soy supplements, some continue eating soy sauce and some eliminate it. As Caroline writes, it's about making informed decisions.
0 -
Thanks, M for looking into this more thoroughly. However, on that second site you note, under drug interactions further along, it says, "Tamoxifen: CYP2D6 Inhibitors (Moderate) may decrease the metabolism of Tamoxifen. Specifically, CYP2D6 inhibitors may decrease the formation of highly potent active metabolites. Risk
Consider therapy modification "I think, however, you are correct. We are talking about a much less concentrated form of quinine. But once again, for those of us who are IMs, it is just one more thing to be cautious of, and if given an alternative, perhaps take it.
0 -
You're right. The "exception" I noted wasn't excluding Tamoxifen, it was actually increasing the risk from Risk C: Monitor therapy to Risk Consider therapy modification. 0
-
Thanks PattyB! Sorry I don't know, did your team win? Great night for a football game!
Susie
0 -
MTG, texax toast is like a big, thick piece of toast/bread that has garlic butter on it and it is sooooooooooooo good with a steak. It is like garlic bread except it is shaped like a piece of toast. Did I explain that right? lol
Susie
0 -
Thanks revcat! I don't know what the exact name is for them. They look like ladybugs or beetles and the farmers originally brought them into the country to do something with the soybeans and they are rampant! grrrrrrrrrrrrrr I hate them. Even though the beans are out around us, they are still here. I think it will take a HARD freeze to kill them, or, I hope so. I am just sick of sweeping them up. Thanks for the website. I will check it out!
Susie
0 -
Ok, I am suppose to put a bar of soap in our bed and my headaches will go away? And, my hubby will think I am normal for doing this? lol hmmmmmmmmm I wonder what else it might do. OMG....you all and your evil nasty minds! haha
Susie
0 -
re: Texas Toast
Have a great monday!
Trish
0 -
Too funny !!!!! And it's by Pepperidge Farm too (i.e. not some small Texas company) !
0 -
LOLOLOLOL
Susie: LOL A bar of soap is for leg cramps.....NOT headaches.
) Too Funny.I think you have the Asian beetles that look like the rounder lady bug and not the boxelders,
but I could be wrong ???? You described them as lady bugs.
When I first came on and saw that texas toast box I had to laugh. Good way to start here.
)Bye for now.....
Bonnie
0 -
Right, Susie you have to put the bar of soap at the head of the bed for headaches ! LOL0
-
I didn't know they were still introducing insects into new habitats to help control other pests. It seems like that has not always gone well . . . oh well, the article on the asian beetles said they think a predator will soon get the population into balance, and then maybe Susie won't have a houseful.
I've been thinking about all the discussion about things that could inhibit tamoxifen metabolism and I would just like to point out that the long-term studies that have shown its effectiveness were done on women who had no idea about cyp2d6. So maybe it can be even more effective if we are aware of those issues, but maybe there's something going on there that an occasional benedryl, tonic water, or even half grapefruit is not going to hinder. We aren't even sure what dosage is needed to be effective -- so it maybe that we're taking the 20 and it's enough extra to buffer occasional interference with metabolism. The thing with the anti-depressants scared a lot of us, but those are drugs, that like tamoxifen, you take regularly in order to maintain a certain level in your bloodstream. But foods? I'm going with moderation in all things.
0 -
revkat- well said, and that is how my ONC presented it to me. Still, other patients with other criteria and other ONCs may feel different...
Terri- I am really glad that soap thing worked! I told ya it sounds crazy but if you read back on this thread I looked it up before I re-recommended it!
grapefruits also bad for SFBC- see Susan Love's site among others
0 -
I thought the soap in bed was for leg cramps?
0 -
YES TRISH
That is it! And, it is GOODDDDDDDDDDDDDDDD! lol Thanks for posting that. I can't figure out how to put a picture in my post. Any hints?
Susie
0 -
Bonnie: I will post a pic of the ladybugs/beetles when I figure out how to put it in my post. I think they are asian beetles, but, not for sure. I need to do some research and let you know. But, the farmers did import them to help with the soybeans. I am not for sure how long ago it was. You make me smile Bonnie..I hope you know that!
MTG: LOL is all I can say to you! Soap at the HEAD of the bed for my HEADache. Love it! What if I put it.....oh never mind....( wink wink )
revkat: I am not for sure if they are asian beetles. I will have to check on it. But, they are bad out here in the country. I thought once the beans were out, they would leave, but, NO! I don't think the "town" people have it as bad, but, they still have some.
Ok, everyone have a great Monday!
Susie
0 -
Hi Everyone,
Susie... you're the one making ME laugh now. I think I've figured out where you're thinking ofputting your soap. Never mind.
Patti ..... It IS for leg cramps.
But wait....Susie could put one in her pillow case....for her HEAD. Yay !!!!!!!
If it can cure ONE ache why not another ONE says the catbird.
Now how did we get off track on our discussions concerning all these things we cannot mixwith our Big T..... I think it just started to boggle us down.
Take Care
Bonnie
0 -
Oh my ! From headaches & leg cramps to beetles and Texas toast!
That pic on the box of toast sure looks good.... It's got "CALORIES" written all over it!
Terri
0 -
Rachel: I've been doing it ever since I read it on here a few weeks back and I don't know how, but it works! Who would have thought..a bar of soap under the sheets! Would look mighty strange if any of us have someone other than ourselves change our sheets...like say a maid or cleaning lady!
Luckily, we don't have to worry about the cleaning lady changing our sheets cuz that would be ME..lol
Terri
0 -
Susie, YES!! my team won!! our QB got a little 'dinged', though but I think he'll be OK.
I think I am not going to try to keep up with every single thing that might interact with the Tamoxifen, other than prescription meds that definitely are not recommended for concurrent use. As far as food goes, as long as something I ingest frequently, like chocolate, doesn't interfere, I'm not going to worry about it. I am a little peeved with myself that I ordered a huge container of some protein powder, thinking I could use that to boost my system when I don't have time to eat lunch (rarely) -- and when I got the stuff here, saw that one of the three major ingredients was a soy supplement. Now why didn't I think to check that before ordering it??? Anyway, I've decided that whatever soy I ingest normally via diet -- will not worry about - but I WILL be careful not to take ingest it via supplements.
I'm getting a kick out of y'all not knowing what Texas Toast is!! I thought that was standard steak and potato fare, but apparently it's a regional 'delicacy.'
0 -
Hi to all. I have not been on in awhile, but I have a few questions for you. I started tamox Jan 2008 and have lost about 70 lbs. Don't know why. I have recently started having pain in my midsection above the navel. Everthing seems to make me sick to my stomach. I have to eat with the tamox or it is awful. I have had alot of problems with constipation and heartburn and I am taking 2 nexium a day.The drs. just can't seem to find the problem. I also have started having cramps in my feet. I have had alot of side effects from the tamox even brain fog even though the drs. don't seem to believe this. Please if you can give me some input or somewhere to get info. thanks so much.Peace and better health to all.
0 -
Hi to all. I have not been on in awhile, but I have a few questions for you. I started tamox Jan 2008 and have lost about 70 lbs. Don't know why. I have recently started having pain in my midsection above the navel. Everthing seems to make me sick to my stomach. I have to eat with the tamox or it is awful. I have had alot of problems with constipation and heartburn and I am taking 2 nexium a day.The drs. just can't seem to find the problem. I also have started having cramps in my feet. I have had alot of side effects from the tamox even brain fog even though the drs. don't seem to believe this. Please if you can give me some input or somewhere to get info. thanks so much.Peace and better health to all. stef
0 -
Revkat, Rachel and Patty B - I'm of the same mind as you guys, as is my new and great medonc. Foods are fine - with the understanding that soy, which I used to live on as my primary protein, and alcohol should be consumed in moderation. It's the supplements with their extra high doses that should be taken carefully/ watched/ avoided depending. (Although he says that Vitamin D3 is a BIG PLUS.) Even Benadryl is apparently fine since according to him it passes thru the system quickly while T builds up and hangs around. As for Tonic Water, as I mentioned before the amount of Quninine in it is far, far, far lower than medicinal Quinine and again, he actually raised the subject with and suggested it to me.
Not certain if I already mentioned this but he also told me 2 hospitals are currently doing a study to check on how participants metabolize Tamoxifen, the impact of supplements and medications they take and will then check the impact of increasing the dosage to 30 or 40 for lower metabolizers. After that but still a ways down the road, there will apparently also be a study looking into lowering the T dosage. I think we'll all benefit once we get away from the "one size fits all" mentality.
By the way, Patty B and Susie - I'm jealous; a good simple steak, potato and Texas toast dinner sounds really good right now; the soy burgers in my freezer just aren't going to cut it ! Hmmmm .
0 -
MTG, I need to give that Vitamin D-3 a long look and consider taking it. I've read enough to be convinced it plays a role in 'breast health.'
~~Right now, it's so cold here, a big ol' bowl of chili is the only thing that sounds good!
0
