ER+PR-HER-
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if you are PR- the tamoxifen will NOT help. hard to explain why here. I don't have the info right in front of me now, or I would explain. If you hear anything please write.
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Can not the moderaters help answer the ER+ PR- Her 2 - questions?
Why also can the biopsy report with two different labs checking be different than a surgical one??
Than I read on different site biopsy better next report says surgical..
No wonder this is sooo upsetting to us.
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I don't think it is a given that the tamoxifen won't work. I think it is a possibility that there might be tamoxifen resistance.
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If you go back and read the entire thread, you'll find the information you are seeking.
HTH,
PLJ
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It is not true that tamoxifen will not help if you are PR-. I am PR- and low estrogen positive. I will be starting tamoxifen in February. There is a recent publication in the Lancet that is available as full text on the internet that reports the effectiveness of tamoxifen on PR-, even with low ER positivity. I will try to find it later and post a link to it when I leave work.
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I will look at the lancet site. I read the oposite though on a oncology site cancer center.
Guess there is always the opposite answer if you look long enough.
Also is there a board who talks about.. when people assume since treatment is done you are cured!!
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Bar,
Here is the link to the summary of the results of the recent meta analysis published in the Lancet in July 2011.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60993-8/abstract
I found this very helpful as I only have 5-10% ER with intermediate staining. If you register for free you can access the full article and get updates in your email on other published articles in the Lancet.
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Thanks Christina!
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You are welcome! This made me feel better - even the results for those with 4-10% look encouraging to me although they didn't interpret them as meaningful in the analysis. I look for hope wherever I can find it.
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Hi,
I'm ER+ PR-, HER- and I was on Tamoxifen for 4 years when it came back to the same breast and the same kind as the first time, ILC. I'm on Arimidex now and hope it works better than the Tamoxifen. I also had the Oncotypedx and it was a 9.
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Christina,
Thanks, I will read the info.I have also wrote every place I can with that ? so we shall see.
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Yes it looks like any ER+ tamoxifen is a good thing but when PR - is involved that changes..
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I went for a consult out of state at UNC Chapel Hill when I found out I was ER positive, PR negative. I asked whether I might be tamoxifen resistant and the oncologist there told me she didn't have any reason to believe that I would be tamoxifen resistant. My local oncologist said that HER2+ is a factor in tamoxifen resistance and because I am HER2 negative, I will be more likely to obtain benefit from tamoxifen. I am also EGRF negative (HER1). That is why I will start on tamoxifen as soon as I get through this clinical trial of chemo. All three oncologists I have seen are in agreement on taking the tamoxifen although one of them doesn't believe my 5-10% ER receptors are enough to make much difference. She said my cancer would behave more like a triple negative.
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Thanks for the article. That was very encouraging.
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Yes that was helpful and at least someone says to take it. I don't think I ever had her 1, what is that?
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I am 3% er pos under 1%pr pos ond her2 neg, never had the her 1. My mo said we would retest the tumor after neoadjuvent chemo, as those results were from a biopsy. Well, good news is I had a complete pathological response! I am happy, but I can't retest. My biopsy was tested twice already. MO want to put me on tamoxifen, not sure I want to be on it for 3%. I just don't know what to do.
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Bak, http://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor
You found this link! If you go to the past posts you will see a lot of different articles posted. Here is a link about EGFR or HER1:
http://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor
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I would be careful with wikipedia - anyone can post there. Did the article give references?
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Bak94..Don't quite understand but if you are triple neg.. don't think tamoxifen works..
We just have to keep researching ourselves.
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pebee, Yes, there were references.
I'm not a big Wikipedia person either, but figured it would be ok for a definition of the EGFR protein. Here is another definition from a generalized medical website:
http://www.medterms.com/script/main/art.asp?articlekey=32387
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My surgeron opinion was same as MO.. Since on all test I was ER+ not to worry about the PR-So guess I will go with that for now but will keep reasearching..
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I was ER+ PR- and HER-. I was 38 pre-meno..ovary removal, arimidex for 5 years, now coasting.
I think it's good to know your details especially when it comes to BC being hundreds of types of disease.
Michelle
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Carmelle - if you don't mind me asking....
I was 46 pre-menopause when diagnosed. I **may** be in chemo-induced menopause now, but no one knows.
How did the decision to get your ovaries out? I have asked and have been told that it won't make a difference (but the MO can't show me the studies)
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i didn't stop mentruating during chemo. i had issues with hormones prior to bc diagnosis. i am also er+ pr- which not the best mix for tamoxifen. that was the combo. i asked my oncologist if he felt comfortable with removal and arimidex and he said yes.
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Pebee
. I had huge tumor and 6 nodes positive.
I am pre meno but in chemopause. Getting total hysterectomy next month. Am er + and slightly pr+ and her 2 neg. My onc recommended hyster vs just ooph and says lowers recurrence approx 5%. By doing this and taking ai vs tamox.
Prior to starting chemo I did lots of research and I remember coming away with strong desire to take ai based on that info. Onc agreed with me. Hope this helps. I realize that it is a very personal decision and not one to be taken lightly.0 -
Carmelle..
What did they say about tamoxifen and PR-? it won't work?
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Hi,
I am focal 1% ER+ and 'very weak' 10% PR+ and HER2-. I am also wondering about the effectiveness of tamoxafin. It is very encouraging to me to read that you had such a positive response to chemo.
This is my first post. I am grateful for any help, news or suggestions anyone might have. Thanks, Catherine 
Diangosed Dec2, 2011
Grade 3, 5.5cm 0/4 nodes. Mastectomy in January. CAT scans in two weeks. Now awaiting chemo.
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I'm not sure about the tamox, Catherine. But I do know that chemo works best on grade 3 tumors.....so you can plan that it will kick cancer butt for you!
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Hi All,
I just want to join the group and thank Christina for posting this thread as well all the comments other folks have made! I am very curious as to how much current research still leaves a big question mark about whether being PR - means we should stay on AI's longer ( because we might have a more aggressive type) or whether it is not well enough understood to say for sure.
Although I am listed as PR -, I did have a small amount of positivity (4.5%) , but that is below the protocol limit for being considered PR+.
One of the articles that was posted here used < 1% PR- as the proof point of PR-. Does anyone have an opinion on this or experience with what their PR score was ?
I am no doctor or scholar but just trying to see what other flocks think.
Also, I have been on Arimidex for over a year, but have considerable arthritis on it. I am thinking of trying Aromasin to see if my joints feel any better. Anyone else switch with success?
Best to all, Beau0 -
My PR was zero. My estrogen was only 25%, so my oncologist wants me off after the 5 years as he feels the risks will outweigh the benefits at that point.
It sure would be worth a try to switch, lots of people who have trouble with one AI don't with another.
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