Ibrance (Palbociclib)
Comments
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Yes, we're all going to get hit by a self driving bus at 103 years of age because we were distracted pondering how much time we wasted freaking out about this disease.
Seriously ... especially if I don't make it to the end of the year, I don't want to spend that time worrying. Stay positive.
>Z<
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Ha! Well said Z. I had coffee with a co-worker the other day who unfortunately has been diagnosed with lung cancer. She was amazed at how upbeat and positive I am. I told her, there are two ways to do this - curled up in a fetal position sobbing or enjoying every minute, possibly being slightly irresponsible and perhaps, a bit irreverent. I choose the latter!
Thanks to all of you who keep me laughing and looking on that bright side even on the tough days
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Dianarose, my plastic surgeon said about 10 years for silicone implants. But I don't think she was overly concerned about an actual date. She was really going in to remove scar tissue and fix sagging tissues. But all that is on hold.
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My gift to you Ibrance sisters on this Friday night! Pat
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Thanks Pat! My mantra this year is "Celebrate the joy." I look for the joy in everything I can. It is there, sometimes it is hiding, but it is there.
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Ah, chemotherapy!
Of all the things I've lost, I miss my mind the most.
Next in line might be my eyebrows.
Will Amazon.com save the day?
Can I have 3 second eyebrows As Seen On TV? (for $19.98 & Free Shipping!)
Tomorrow will tell!
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Intolight, you are so right. I'm thankful we can all be here to lift each other up when joy seems to hide! Be well, my friend!
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Pat- I tried those eyebrow things. Didn't like how they looked and I had a hard time getting them even . Mine never grew back from my first chemo in 20012 so I am used to drawing them on.
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My mantra is:
Worry is a misuse of imagination.
Unfortunately, I don't always listen to myself.
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A friend sent me this...worry is like a rocking chair. It will give you something to do, but it won't get you anywhere. -Proverb-
So true!
C
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Patgmc. Did your jaw and teeth hurt. I got the magic mouthwash and it helps with the gums but it doesnt help with the terrible jaw and teeth pain. I had to call oncologist today and just ask him if it could be from the ibrance which i have 3 pills left if this round. Or could the xgeva be causing it which i just got the first injection a couple of weeks ago. He told me to take a break from ibrance till next round and we will not do the xgeva shot this month. He also said he hasnt heard of this side effect. Has anybody else had this kind of reaction to meds. Thanks in advance for any help
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melmcbee, I have occasional teeth pain and did not even correlate it with the Ibrance. Now I will rethink it, and relax a little. My MO said I can't have any work done on my teeth while on Ibrance so I have been praying I don't have any issues. I had my last wisdom tooth pulled 2 months before my dx because of teeth pain, so I just assumed it was related. Yes, I am 64 and had 1 wisdom tooth left. Chalk that up to old dental procedures!
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IntoLight. I am sorry you are having Jaw and tooth pain. I am on 6th month Ibrance/ Letrozole. I have occasional mouth sores, but not tooth and jaw pain. Hope you can get this resolved.
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intolight- I believe it's the Xgeva that causes the jaw issues.
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Thanks. I don't have good teeth so it is probably not the cause.
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Zometa is similar to Xgeva and I had a lot of dental issues with it. My teeth and jaw hurt and I had a lot of bone loss in my jaw. Had to have crowns, a bridge and one tooth extracted. I am fine since I have been on Xgeva but everyone is so different
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melmcbee, I hate that you're having such pain. Mine was limited to mouth sores/ulcers with an especially annoying one on the tip of my tongue. Before I got on this treatment, i went to the dentist for a full work-up and cleaning. I have friends who have had some jaw issues because of bisphosphonates and, since I was starting XGeva, I erred on the side of caution. So far, no problems after 9 cycles. I pray that yours clear up soon.
Do all of you take very high doses of calcium? I doubled up on mine and got back into normal range. The nurse said XGeva pulls calcium from the soft tissue into the bones so it must be replaced.
Dianarose, I'm counting on these stamped-on eyebrows! I may get my husband to do them so they'll be symmetrical. He's already been assigned (along with my oncologist and sister) to pluck my chin hairs if I'm ever in a coma. Now he can also make sure I have eyebrows to the end! I guess 2012 was "the Year of the Eyebrow" as mine went then and never returned! C'est la vie (sp?)!
Scan results for me on Monday. Nine cycles down and expecting good things (gulp)! I have a new "something" that was concerning me but I think I figured it out on the way to get scans....increased awareness/numbness on right side of my abdomen. Of course, the more I pressed it, the more I was sure it was swollen and perhaps had fluid build-up. While stopped at a traffic light, my Pollyanna self realized it's the exact spot where I've had 9 of those XGeva shots. I think I'll have them move to the other side this week. If this happened to you and it turned out to be something awful, just don't tell me until Monday night!
Happy Saturday!
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Thanks ladies for the info. You reminded me that I need to take extra calcium. Pat I hope you like your eyebriws. I barely have any either. Hope everyone has a great weekend
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Pat, best of luck with the scan results. I am pulling for you!
I take Zometa so perhaps that is why I have teeth pain. I have no jaw pain. The pain is minimal and only occasional, and I tolerate Zometa otherwise fine so I won't seek a change. I like that Zometa is an infusion rather than a shot.
I do take calcium, zinc, and magnesium, and extra Vita D as per my MO's instructions. As far as eyebrows? No, I don't have much any more. I have had to pluck mine since i was 15 (think Brooke Shields!) I am glad I don't have to do that anymore! I have never been into the dark eyebrows so I just use a pencil.
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Pat- do you get your Xgeva shots in your stomach??
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Pat I have scans on Mon too. For some reason I am a little nervous this time. Hope everything is good for both of us. Also, I have my Xgeva shot in my arm. It seems to work for me in the arm rather than the tummy. Thanks for all your posts. The Onc nurse told me to take Rolaids tablet once a day and that would help with calcium replacement because of the Xgeva shot.0
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Dianarose, I do get XGeva in my tummy. It seemed an obvious choice since I don't have feeling there because of my TRAMflap reconstruction. I kept letting the nurse put it in exactly the same spot so now I'll switch.
airlinegal, I'll be praying that your scan results are good. I've been more nervous this time too but am trying to remember that all we have is today. I'm determined to get out and exercise more regardless of the results. I think I'll hop aboard Z's exercise thread! I've let my Radical Remission plan slide just a bit so I'm hoping to recommit to that as well. I reached a point where I couldn't decide if drinking all that juiced kale was going to make me live longer or if it was just going to SEEM longer! Wishing you well!
About eyebrows: I tried the Anastasia stencils from Sephora and never could get them even so don't waste your twenty bucks. I'm still looking for the perfect mechanical eyebrow pencil if anyone has a recommendation. I've been using an Anastasia eyebrow marker with mixed results. First World problems, right?!
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A bunch of things....
Pat, I think it was you (or Faith?) would suggested the OBR Daily email. To whomever, thanks again. They include an article in their recent post about a Phase III test of abemecliclib + fulvestrant. Does anyone know anything further about that? Is it just a cousin to palbociclib + fulvestrant or another future option if/when progression occurs on p + f? Z, do you know anything about this?
Pat, best of luck with your scan results!! Sometime I'd like to know about your Radical Remission plan.
Airlinegal, good luck with your scans tomorrow!
Dianarose, I get my Xgeva in the lower (saggy) skin of my upper arm.
And last...wouldn't it be nice if there were a combination of one of those real eyebrow "experts" (like in NYC/the bigger cities) with a genuinely talented and subtle tattoo artist, who could tattoo soft brows in place??
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I intended to include the link to the OBR Daily article...
https://investor.lilly.com/releaseDetail.cfm?ReleaseID=1028908
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I get my Xgeva shot in the saggy part of my arm as well. Sore for about a day or two but no numbness. Would not like it in my belly. I do numb the area on my arm and butt before shots with lidocaine. Takes the edge off.
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SandiBeach, thanks for your reply on the saline implants and the inverted dimple. I'm guessing that it's an impending "blow out". I've never had anything else in all of these 27 years to change with the implant, and now this. Not frightening or even a worry, but I did ask my onc about it. She (onc #1) said that if it deflated, we'd just have a breast surgeon take that one out and "pop another one in"! As you may imagine, 27 years ago my one reconstruction nicely matched my remaining breast. Now, the "new" one is still perky, and the old one is sad looking....at 71. Oh, well....
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I also take my Xgeva shot in the arm. As far as Calcium, my onc has had me take Calcium with vitamin D twice a day from the very beginning and told me to take it 4 times a day on the day of my Xgeva shot.
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Good luck and prayers to everyone scanning this week. We are all with you. We've all been there and are sending good positive vibes and gentle supportive hugs and understanding. Usually your body speaks volumes. if you're feeling good, then your scans should follow that theme!! XGeva here, back of my arm and it really just burns and that's it. Two days later slight headache and some tiredness and yes more fatigue feelings. Over all it too bad and my calcium levels have been good thank goodness. Hugs everyone ~M~
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JoynerL, maybe the surgeon can pop in two implants so you can have a matched set!! Ahhh..memories of the perky days.
Thanks for the link to the OBR article.
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Joyner - It's a long story but abemaciclib is showing signs of being more targeted to the CDK4 pathway (Ibrance is CDK 4 and 6). It seems targeting the CDK 4 pathway is more disruptive to cancer and less to normal cells so ... more effective and less side effects.
Abemaciclib is being combined with hormonals in most trials just because no one is going to take a woman who is responsive to hormonal treatments off of hormonals at this point, however it showed efficacy on its own in early trials and palbociclib did not. Palbociclib only works coupled with a hormonal treatment.
Abemaciclib is still not a magic bullet but it has different and possibly better efficacy. It is something I might switch to if I hold out on Ibrance long enough to be able to consider the option. Kisquali, in contrast, is the same as Ibrance with respect to how you would use it and its efficacy. There is a possibility that Kisquali has different side effect for some women... more gastro, less immune system. For the moment I am sticking with the devil that I know, as they say.
At least Ibrance is working for us.
>Z<
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