Ibrance (Palbociclib)
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Dunesleeper - I mostly take ibuprofen for my side stitches/rib pain. Seems like that helps the most.
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Patty, haven't you been on this for a while? Have you been sick all this time?
Well, I am so glad you are feeling better, and I'm sure the 100 mg dose and your charming attitude will kick it to the curb. Oh yeah!
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Patty, when are you taking your Ibrance? I know we're all different in how it affects us, but I wonder if when we take it could be a factor? I take mine after dinner (and we eat late -- so it's often close to bedtime), and thankfully have had very few SEs -- mostly severe bloating and noticeable exhaustion -- but no nausea, etc.
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Anybody getting bladder irritation? I'm on Femara/Ibrance, second cycle, and feel like I've got a UTI. It responded slightly to a 7 day course of Bactrim, but it still kind of there.
Other than that, I'm liking this protocol. I have more energy than i did on Xeloda. Let's just hope it works!
Jennifer
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Deanna. I will have to try to change the time I take my Ibrance. I usually always take it first thing in the morning with some juice. Not grapefruit juice.
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Oh, Patty -- you need to take it on a full stomach -- immediately after a meal! That's an absolute must! Didn't they tell you that? Or has it just been too hard to keep food down?
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Patty, I take mine after dinner also, on a full stomach. Myra
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I take mine after dinner. Between 6-7 and I take last dose of round 1 tonight!! I have tolerated it well. Hoping it's working!!
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Patty, sorry you are having those problems with Ibrance. I always took it with a sandwich at lunch - ate one half, then the med, then ate the other half. I wonder if something in your diet might be causing a reaction. My heartburn was worse on Ibrance, but it got better after I cut out tea. Hope you feel better soon!
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Welcome to all the newbies! Had my checkup today, on round 8 of Ibrance. My onc is very pleased, latest scan is very stable and tumor markers are way down. I feel good and am working full time as a nurse. Will be having a pet scan in February to check to see how active the cancer is. My onc constantly questions me about side effects, she says this drug is so new that they are still finding out more about it all the time. I had some slight redness on my chest , probably a combination of nerves and sweating, and she made me show her my back and the rest of my body to make sure all other areas were clear. Redness cleared soon after I left there but I bet she will check it out again next time.
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Jennifer,
I have had bladder irritations and infections. But, I've always been prone to them and with a low blood count, it has been worse. The lack of estrogen doesn't help either. My urologist has me taking a preventative dose of vitamin c and d mannose. They have helped the past few months.
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If you had chemo recently, that could be the cause of urinary tract irritation. I had cultures done two different times after chemo, and they were negative--no infection. My onc NP said that feeling like you have a UTI is a known side effect and offered a drug to help me feel better, but I declined and the problem went away on its own. Of course, you want to check to make sure it is not actually an infection.
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Thank you all for the replies regarding the oophorectomy. It is scheduled for November 30th.
I had a pleurodesis on October 9th and was in the hospital 11 days. That is when they switched me to the Tamoxifen with the Ibrance. Since then, I have lost ten pounds and I am nauseous every night and throwing up. I am hoping when I go to the doctor this week he will put me on something else. I never had many issues, other than fatigue when I took it with the arimidex.
Good luck to all of the ladies waiting on results.
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Yes, nice to see you Patty! I take mine after dinner too and by bedtime I am slightly sleepy as well. No nausea at all. Deana, I too feel very noticeable exhaustion after round 3. I actually paid a visit to the ER Sunday for racing heart and shortness of breath but they found nothing. New bloodtest Thursday...Yah Lynnwood! Happy dancing for you! hopeful, sorry for the long hospital stay. Not fun.....I hope you get on something to make you fell better. Best wishes on the surgery and let us know how it goes.
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I have been taking the same thing for about 2 months maybe a little longer. I also have low wbc. I still have these hot flashes but that's about it for side effects
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Lynn. - yea ! Good news indeed
I ave tried it with food but not noticed a difference. It is nearly impossible to keep food down. But if it helps I'll tr again. The nausea , vomiting stuff has been going on long before Ibrance and Falsodex so I really don't think they are the problem. Ibrance is of course keeping my wbc low which is why mo decreased it. Wbc was .3 before I took a 2 week break but now its up to .7. Just trying to stay away from anyone sick. Kinda hard to time of year
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Lynn - so glad to hear your great news!
Jessica - welcome!
Artist, Patty, Allison, Kaption - amazing how we are all facing different issues. I am hoping and praying everyone improves and feels better soon.
Just wondering if anyone is still experiencing pressure headaches or weird headaches? For the first 3 months on Ibrance, I was so thrilled to finally be on a treatment with absolutely no side effects for me and so far keeping me stable. Then came month 4 and the headaches began, but at first not bad ones. Then they persisted everyday and became worse. I had the brain MRI, and except for mets scattered around my skull, my brain is normal. Then on my week break, NO headaches. So now I'm 2 weeks into month 5 and the headaches began again immediately and have become Migrane headaches. Every day. Good thing Advil helps. I called my onc yesterday and her nurse said just continue taking Advil and we will see what happens on my next week break. I am still on the 125 mg dose which is where my onc wants me to stay for as long as possible because I have other mets and she wants to give the Ibrance the best chance to work.
So ladies, anyone else getting headaches? The nurse said they are not hearing of this as a se. Of course, this drug is still new.
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Hummingbird and Patti,
I heard acupuncture can help with headaches and with nausea. I've heard that most insurance companies, however, won't cover it. Such a shame if it is really so helpful as many claim. Anyway, worth checking your insurance to be sure. Hope you have relief soon! I doubt it is the Ibrance since those SE's seem rare with Ibrance.
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Lynnwood, I love hearing that your scans are stable and TMs are way down!!! That's great news!
Welcome, Jessica! Glad you've found BCO and this thread!
Oh, Hummingbird, those migraines sound miserable. Like you said, headaches aren't listed as a known SE, but I'm going to do a bit of digging and see if I can come up with anything to explain them. Are you taking any other meds or supplements that could be interacting with the Ibrance? I'm also in a FB group for Ibrance users, and I think someone there also recently mentioned having headaches. I'll see what input she got.
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I just started Ibrance and Femara 2 days ago, so far so good.
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Lynnwood - Glad to hear about your good scan news!
Patty - Hope you are feeling better soon.
Hi Jessica - Welcome!
Hummingbird - Hope they can figure out how to deal with your headaches. Boy, it sure does sound like it's Ibrance-related if it consistently goes away on your week off.
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Hopeful - So sorry to hear about your hospital stay. I hope your surgery goes well and is uneventful!!!
Got my 3-month PET scan results. For background, I have disease in my spine, ribs, femur, scapula, sternum, and pelvis. Also supraclavicular lymph node and a lung nodule. The SUV uptake first time ranged from 2.5 to 12.3. Report says, "Significant response to therapy with no evidence of FDG avid residual metastatic disease. Almost complete resolution of the supraclavicular node. Lung nodule is significantly smaller with no abnormal activity." Feeling very thankful!
I did inquire about my one-time elevated liver enzymes, and they confirmed that other meds can definitely cause the enzymes to rise sometimes. So don't panic if you encounter this.
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I love the good scan reports here! Very encouraging news.
I'm just wondering how long after you started Ibrance did you have your blood tested? I've only been on it for a week, and I'm scheduled for a blood test tomorrow. It seems too soon, but maybe not? Or maybe I'm just trying to get out of getting poked tomorrow.
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Moissy! GREAT news on your PET scan! I am having one in February to check how active my Cancer is. My SUV ranged from 4-9.8 so I am anxious to see
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Great news Moissy!! I just loved reading that!
Finished cycle one .... and started rads today. Should I expect anything in the 7 days off?
As far as headaches goes.. I have not had one tonight (never migraine) just weird pressure and it passes and tonight I have not had any and I am off of Ibrance now. So who knows.. I wonder if I am just aware of any little pain there is anywhere. I think the other night I felt a pain in my elbow and smiled. Hope everyone has a nice night.
Carol
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Moissy, those are Wonderful scan results! I'm happy to hear that!
Thank you, ladies, on your thoughts about my headaches. One of the great things about this thread is being able to ask and compare with you and get reliable information here. It helps me to read that I am not the only one having this se. dlb - I take Femara with the Ibrance, and calcium/vitamin D. Nothing else. Thanks for checking the FB Ibrance group. I'm interested to hear what you find out.
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Welcome Jessica and Cindy! Oh man Patty, that stinks! I sure hope you will feel an improvement in how you are feeling soon...Hummingbird, I start up my new round tonight and am kind of nervous because I am just now feeling better from the rapid heart beat and shortness of breath. I was getting pressure headaches, yes, plus a feeling of burning nasal passages. I am pretty darn sure it is the Ibrance as mine stop on the break too. Still have super sticky, dry mucus up there though. Yuck, sorry TMI!!! I will let you know if the headaches start up again this week. It was usually in the morning, as soon as I woke up, but nothing like a migraine and dispersed fairly quickly. I am still on 125 mg but wonder if I will reduce if the other symptoms start up again. It was kind of scary.....Went to the ER. That's a great report Moissy! Also, thanks for the liver enzyme observation as mine were elevated last time even with good scans so I was worried. Seeing a liver specialist on Monday for some feedback.
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artist, good luck with your appointment on Monday and with starting up the next cycle tonight. Glad to hear your ER visit didn't find anything serious. Does sound scary, though. I hope you don't get any more headaches. Yes - I would say the same thing, I also get that burning feeling in my nasal passages. Crazy - I never thought these would be the side effects!
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Moissy and Lynnwood- happy for both of you!!!!
Babs
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Great reports Moissy and Lynnwood! In regards to headaches, I had terrible ones when I was on 125mg, but they are not nearly as bad on 100
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