Ibrance (Palbociclib)
Comments
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Yes Shetland, I too hope this is a long term med and that I get back on and do fine at a lower dose. I hate to burn up an option already. I would think a a low dose and constant would be better than a high dose and sporadic too, but all that sounds like future discoveries. I was surprised that my Onc did not know there is a lower dose...
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Sarah, I stopped the Ibrance and I'm on Xeloda alone. So far it seems to be doing the job, although I've had to have my dose lowered due to HFS. I'm on 2000mgs a day, 14 days on and 7 days off per cycle. I feel well and have energy- blood work is good, so that whole worrying about counts seems to not be an issue with Xeloda.
I'm sorry you have a bit of progression, Myra, but you did have eight good months. Best of luck with Xeloda. You can join us on that thread. It's active, and many of us are having success keeping our mets stable. Some have even regressed quite a bit. I'm hoping my next CT shows regression, but stable works, too.
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Shetland, I hope my hip pain is just joint pain from the faslodex or ibrance...I'm not taking letrozole. Noticed that is seems to be getting increasingly worse, although it's mainly in the morning when I wake up. My dx was in July and I haven't had any further scans so I'm assuming that one will be coming up shortly. Praying for good news! SE's aren't too terrible, but the issues with the watery eyes and nasal passages drive me crazy!! Still have all of my hair with no thinning so that is a blessing...
Myra, best of luck to you on the new trial!
Hope you all have a blessed and happy Thanksgiving !!
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I have a silly question, but thought I'd throw it out here anyway. I rarely drink, but yesterday afternoon/early evening we were at a friend's b'day party and I actually had two drinks -- delicious chocolate concoctions -- one a chocolate wine and one with vodka -- over the course of 4 hours, with dinner in between. Then I remembered I needed to take my Ibrance, and I wondered if taking it with alcohol in my system might make it worthless, or could even be dangerous. Fortunately, it was still early when we got home, so I waited and took it maybe 3 hrs. later (like 11:00) with some cottage cheese. But I had an absolutely horrible taste in my throat and mouth all night, and still have it today. So my question is, what would you have done? I'm thinking because Ibrance is so potent and taken orally, this may be something to keep in mind, especially during the holidays!
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Masonsmawmaw, my joint soreness is worse in the morning.
For eyes I am using Systane lubricant eye drops. My optometrist suggested using an eye gel at night. Anyone have a favorite kind?
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Regarding alcohol, I don't see it listed as interacting with Ibrance. The consumer info only mentions grapefruit juice. But I figure we are already asking a lot of our livers, so... Best to ask the doctor.
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Deanna, I wonder if we called the company and asked them. I had a glass of wine I think an hour before .. I may call them and see what they say. I do know that my MO told me I could have a couple glasses of wine a week if I would like but didn't mention what time of day around the Ibrance.
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Deanna, quick update.. I called the drug company. There is not a report associated with alcohol consumption doing anything to the Ibrance, only Grapefruit- So you can rest on that one. No interactions... I will bring it up to my MO when I go to Boston as well.
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Thank you Shetland!
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Carol, thanks for calling Pfizer. I'm glad to know they didn't think it was harmful to take Ibrance if you've had a drink or two. I guess my insides are just sensitive anyway, so it probably felt like a bigger deal than it was. But I think in the future -- if I attend a party where I think I might want a drink -- I'll try to take my Ibrance earlier, so that I don't feel like I'm mixing them.
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I just had a glass of wine... being that I have 2 days left of week off of Ibrance I just took advantage. I think that is a great idea.. just take your Ibrance later if you have a cocktail.
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I am on an Ibrance break since Friday, but good to hear alcohol can be consumed as I really need a cocktail this weekend. Bailey's and coffee for me! Yum! (DS is driving me NUTS! Which is a whole other story) Saw a liver specialist today about the enzymes and he was clueless about what Ibrance is?? So he plans to do some research while I take a break until next week....
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Hi ladies;
Congratulations for everyone that got good news.
For those who didnt please hang in there.
I've been on the 100mg of ibrance / letrozole for about 5 months now and my tumor markers keep going up. My scans results in early October were good so i don"t know what to think.
Cheers
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theziz-what do you mean "not good". I've been on the same treatment for about the same time and my MRI in Oct showed mixed results. Some of the larger spine mets showed some reduction but some smaller spine mets showed some increased activity. I get scanned again in January. My MO does not use tumor markers because he doesn't feel they are reliable/helpful. Often I feel like you do too--not sure what to think.
What did your MO say about the scan results and rising marker?
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Anyone out there experience palmar-plantar dysesthesia, similar to the kind you get from Xeloda, while on Ibrance/Femara? Since being on this, my fingers are cracking and peeling.
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The Ziz, my tumor markers went up on Ibrance every month for 6 months. We almost quit it twice but my scans were stable. Then my last scan finally showed one of my bone mets grew a little in size, but that same month my tumor markers finally leveled off. So, now we are sticking with it just a bit longer to see if the tide is changing. Apparently he has had a patient who took 8 months to respond to the Ibrance. (that's almost where I'm at now). Its very disconcerting to be in that unknown area where you don't know whats going on. With regards to using tumor markers, if your MO thinks its a good measure for you personally, then it is. I have one marker that is always low (but above normal) but moves slightly up and down with the changing tides, so it is fairly reliable as an indicator that something else might be going on and should be looked further into. But, I do believe the scan is the ultimate telling. Wait until your scan in January and in the meantime, try not to worry too much (I know, easier said than done)
Stefanie
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I am still waiting to get weekly blood tests to see if my liver enzymes go down by quitting ibrance. I have a feeling they will but hope I can resume a lower dose. But it seems that it was also causing the rapid heart beat and shortness of breath as that is feeling much better soon. So my future of Ibrance is questionable.
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I start my 3rd try at the Ibrance tomorrow (75 mg this time). Hopefully my white cell count won't drop as far this time, plus I got the Marinol to take with it. So hopefully the nausea will be better controlled. I'm kind of nervous about how I'll react to the Marinol. But I guess I'll find out soon enough. So glad it worked out that I could wait until after Thankgiving.
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Hi ladies;
Thank you all for being there for me.
I went to see my MO and I was mistaken. My tumor markers actually went down 35 points, the WBC are good.
I'm from Costa Rica and we alwaysdance to celebrate and the DR had to dance with me.
Cheers
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I love Dr Vogel. I get kisses. Myra
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I love my doctor. She says I'm her favorite patient😉
Myra, are you HER2+?
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Theziz, thats great news. And I LOVE CR. Been there 4 times. One of my fave places in the world.
Stefanie
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Hi anyone is taking examestane plus palbociclib? how is going SE?
Thanks!
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don't know status. Original dx 18 yrs ago. Bone bx 12/4/15 for a full reading. Myra.
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is Ibrance a form of chemo in a pill? I get conflicting information.
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Patty, that's the magic question! Different oncs say different things. My onc calls it chemo. When it's delivered to my house the box and bottle are labeled chemotherapy drug and its placed in a bag marked the same. Some oncs call it targeted therapy and do not consider it chemo. I guess that this drug is so new that they're not sure what to call it yet.
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I have a question! I am on my second round of Ibrance (new scan will be done in middle of Dec to see if it's working) - We are on the pretense that I am er/pr + but I may not be. I have multiple lesions in my ribs right side, (even broke a rib from sneezing and now they are radiating that lesion so it can heal and I stop dislocating and breaking it) I have always felt some kind of kink or pain on my right side in one area only and not where this rib is broken either- IT Never gets worse but has been there since August and before I was even diagnosed. If you press or push on the area I can't get it to hurt in that spot or pin point it if you push there etc. Heat does help it to where I almost can't feel anything but it comes back. The same thing is now on my left side, not quite as noticeable but now that I feel every single twinge of course I think it's a new met.
If Ibrance is working for you, do you still feel pain that did not go away and if so how long did it take before you realized it finally got better?
Thanks Carol
Does Ibrance take away all the pain and if so how long did it take for you to notice it was working?
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LovesMaltese, we are in the same place in our treatment. That's kind of cool. It is my understanding - correct me if I'm wrong - that it takes 3 to 4 cycles for the Ibrance to work its magic. I sure don't like waiting that long to find out whether or not it's working, but I do my best to be patient. I started cycle 2 yesterday but am currently in the chair receiving rbc's. I hope your pain lets up soon. Good luck!
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Hi Dunes, I have tolerated the Ibrance well so that scares me. I'm 63 and I thought I would be getting more hot flashes but I'm not. That worries me. I have turned into a hypochondriac and once I can ditch this walker they are making me use I would like to try and think about other things rather than did I just feel a twinge? I'm done with rads a week from tomorrow, can't wait. I also am trying to do a vegan diet and this already getting old but I will try and stick it out. I was able to find pats made out of beans that are just protein. I add my veggies to it. I drink almond milk not crazy about that either!
I don't know what's up next for me if Ibrance isn't the drug. Will know this in Dec. right before the holidays. Thanks for responding. Carol0 -
has anyone had radiation treatments while on Ibrance?
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