Liver mets: resection, ablation, SBRT, Y-90, anything else?

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  • nicolerod
    nicolerod Member Posts: 2,877

    So i spoke to the IR today. We are going to do ablation to the 1 liver met that keeps growing (that previously had Y90-1/2 dose) I didn't realize you go under general anesthesia for this. She also answered my question that she does biopsies and treatment for lung mets she prefers cryo for lung mets.

    So does anyone have info on liver met ablation?? BEV?

  • nicolerod
    nicolerod Member Posts: 2,877

    Is there a thread for Lung met treatments??? NOT mets to lung..but actual treatments like Cryo??

  • vlnrph
    vlnrph Member Posts: 515

    This thread has been pretty quiet for some months so here's a bump and information about a new therapy being tested in ClinicalTrials.gov #NCT04572633 - it involves hitting hepatic lesions with sound waves. Called histotripsy, my cancer center is a participant along with other Midwest sites and Florida.

    The noninvasive technology can be used on tumors up to 3cm. Protocol CSP1427 is also titled HOPE4LIVER (which I like!). A phase I report was recently published at https://doi.org/10.1080/02656736.2022.2112309


  • nicolerod
    nicolerod Member Posts: 2,877

    vln....that is actually not new news unfortunately they too are VERY picky and will only target 1 or 2 leisons....there were a lot of restrictions I looked into them a while back.

  • vlnrph
    vlnrph Member Posts: 515

    Yes, HistoSonics was using their VORTX Rx device for prostate a decade ago however the Theresa study for liver was just published this summer. So, it's newer than Y90 which has been around since the 1990s.

    As I understand the procedure, a clear path is required - no ribs in the way, etc. Also interesting is the marketing partnership with GE HealthCare. Their MRI development facility is right down the road but there are, of course, many other locations handling various manufacturing and research functions.

    My mets are probably too widespread for this to work anyway. I'm awaiting results from the Eovist scan done Tuesday in order to start a management plan…

  • ninaca
    ninaca Member Posts: 232

    Nicolerod, Did you get your information on liver ablation? I had it done in June 2016, 2 mets, new tumor found January 2020. It was laparoscopic but still needed time for recovery.

  • nicolerod
    nicolerod Member Posts: 2,877

    I didn't have it done..I wound up having 2 brain mets and had to get Cyber Knife...

  • moissy
    moissy Member Posts: 371

    I’m so thankful to those who started this thread years ago. I followed when it was more active and learned so much from them to store for future. Last year I developed a liver lesion that did not respond to my chemo. I have heavily treated, widespread disease but was generally stable elsewhere. my lesion was not suitable for ablation. After consult w liver specialist, I was approved for y-90. Two months later, PET showed zero metabolic activity in liver. I only had mild fatigue for a few days. Proved to be a great alternative for me.

  • amel_83
    amel_83 Member Posts: 236

    Hi

    I was wondering if anybody with more than one liver mets, and/or other locations of disease as well, had some local treatment for liver metastasis. I read that overall survivor is better in people treated locally along with sistemic therapy, but it seem that having bone mets esclude me from that…

    I will like to ear somebody else experience