Ribociclib/Kisqali with Letrozole - Any one on this combo?
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very sweet of people to enquire after me. The big status quo. Grumpy with moodswings but I think stable on the cancer side of things. Doing less scans because fed up with blips that come and go . Some scanners are way too sensitive . Also getting allergic to more and more contrast / reactive agents so thought limiting the scans gives my body some time to regroup.
Starting year 7 on the combo. Not celebrating but it’s on my mind obviously.
take good care my lovelies xx2 -
Oh, Forza! So nice to hear from you. Year 7 is an inspiration and so I will celebrate you.
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@Forza 7 years is amazing!! Keep it going 🤗
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oh thanks guys ❤️❤️❤️
I feel bad for not checking in more.
Combination of very tired + living a lot. It’s a daily pendulum.
what’s going on with all that gas ??? I just read up a bit.xx
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I have been on Letrozole for 4 years and combo Letrozole and Kisqali for 1 1/2 years. Initially the treatment looked effective however my latest Pet scan is confusing. Does anyone have a clue as to why my latest PetCt scan showed no cancer activity in my breast tumor- nothing lit up, but my two sentinel axillary lymph nodes did light up and actually grew. I have never had breast surgery because I cannot risk radiation because of a history of non-small cell lung cancer for which I had a lobectomy in 2020.
I also showed an ESR1 mutation so I know that at the very least I am not blocking much estrogen.
Any insights will be very appreciated.
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@boxwood My diseased lymph nodes were still mildly active after my breast tumor disappeared during chemo. So I think they can have a mind of their own. Hopefully your team can soon give you answers about whether you can stay on your current treatment or need a change.
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I’ve been put on this combo, I start on Wednesday. Yesterday I had my first ovarian suppression shot (zoladex) and it’s every 3 months and my oncologist asked that I start the medication in a week’s time - not sure why? I was offered an option of one month tamoxifen or just start in one week and I opted for the latter.
What time does everyone take the medication and does it make a difference?
Anything that has helped with the side effects? Any advice for the newbies are welcome.
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@raysal I don't think a week will make much difference. I am not sure why your oncologist is having you delay, but are you having an ECG to make sure your heart is strong? This is pretty standard, and perhaps that needs to be arranged.
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@tougholdcrow yes I had my baseline ecg and getting one monthly as well as blood tests during the end of my break week.
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@raysal I take them at different times in the evening but that's just because my sleep is all over the place and some days I'm not up early. I started with times that were most convenient for me. I know some people take with meals but my side effects have been pretty manageable so timing makes no difference to me. Hope you're able to tolerate it well also!
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Hi all. I completed two weeks, one more to go. My most noticeable side effects are extreme fatigue and for the past 10 days about mid-day I’m feeling sore all over, pain in joints, etc. It lasts until I go to sleep. I’ve been on Letrozole for quite a while and haven’t had too much pain but wondering if the combo of Kisqali and Letrozole kicks that up or it’s just the Kisqali. My left hip and pelvis wings have continued to be painful (mets there).
I get labs today and ECG tomorrow to see how I’m fairing. My next CT scan will be July 2nd.
I hope the rest of you all are managing your treatment and enjoying summer.0 -
I think the Kisqali does make the joint pain worse. I switched to taking my Kisqali and Letrozol at night and that has helped me. Drinking a lot of water during the day has made a difference also with my joint pain and fatigue. I can tell when I don’t drink enough. I have been on the combo since October 2024 and it has not gotten worse. And the combo is working so that’s good news!!
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