Single Hormone Receptor Positive -> ER+/PR-/HER2-
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Thanks Anna, I seem to have found a reason to feel alittle better about the future.
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Really? i would like to see this research. best news i've heard all day
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I am ER+ 100% and PR- 0% and so curious as to what this means as far as aggressiveness of the tumo
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I was er 95% and pr 0%, my tumors were grade 1 and 2 both mitotic score 1 slow growing. I don't think there are enough of us to come to any conclusions on aggression with er and pr percentages alone.
Are you her2 negative?
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HPFULL/Meow13
I have the same as you 100% er and pr negative and her2 negative.
Is our cancer considered to be very unusual then?
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I was pretty close >90% er+/0%pr and hr-. Our type seems to be a bit less common than er+/pr+ hr-, but I don't think it is rare so to speak. There still seems to be a good bit of controversy over the degree the absence of a pr receptor might change the outcome or increase the aggressiveness of the tumor.
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yes HER2 negativ
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Approximately 35% of breast cancers are PR-, so not so rare! Most have high Oncotype scores, so are considered aggressive, although many are only grade1 or 2.
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Since my diagnosis I have been reading every about BC and this thread is where I got the most useful information. Thank you everyone for sharing your knowledge.
I’m 100% ER+ (8/8) and PR negative (it’s written 3/8 and that it should be repeated during excision in order to confirm). These results are from core biopsy (FISH). HER is negative.
I want to ask the surgeon to have Oncotype and Mammaprint done, regardless of paying for the tests myself, but still not sure if I will succeed.
Thanks again for sharing your experiences. It helps a lot.
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I just had my first follow-up mammogram post-surgery, and everything was clear. One year down, 4 to go!
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That's great news Princess!!
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That’s great news princess buttercup :
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Great news Princess! It's always such a relief to get the all clear.
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Thanks, all. It's good to get this done before the holidays. I wanted to hug the tech when she told me I was good to go for now.
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Congratulations Princess Buttercup!
To digress: Isn’t it interesting how after diagnosis and treatment we tend to think in 6-month time increments (or I do)? My 6 mo mammo resulted in another biopsy (negative - whew). MO checkup this month. Then I’ll be looking toward March when I have a mammo and MRI. All I want to do is stave off a recurrence - just like all of you. The combination of Single Receptor plus, for me, the invasive nature of my cancer, keep me aware at all times of the possibility of recurrence even as I go about my life. It’s an interesting emotional tightrope we walk.
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I wonder if I should be more concerned than I am. Also single-receptor positive here, IDC and Grade 3. My doctor has me on the once a year mammogram schedule. But I will see my MO in March and will ask then.
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Princess- I'm the same, single receptor positive, grade 3 and also 1/5 nodes. I only go for a mammogram once a year. I get checked by my Mos every 6 months on alternating schedule.
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I should have mentioned that I have been on 2x year screenings for many years due to high risk and many many biopsies. Mammogram/MRI on an alternating 6 month schedule.
I will say that my cancer was discernible ONLY by my MRI. Couldn’t be seen by mammo or ultrasound so in considering asking your doctors about adding MRI to the mix, this is worth mentioning. Mammo and ultrasound have missed other suspicious growths which, although not cancer, were more concerning than the garden variety benign bits.
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Thank you Bravepoint and Patsy.
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According to my Docs, a lumpectomy breast should be mammogrammed every 6 mos for 2 yrs. However, following mastectomy, the unaffected breast only once a year.
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Murfy - Interesting....I had a lumpectomy and that was never suggested to me.
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My imaging center used to mammogram my DIEP side as well as the real. Last year they stopped doing the non breast tissue side. My oncologist said makes sense. I believe the insurance company is making that decision.
Still does the MRI though.
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I must say the technicians I don't think thought I had a simple mastectomy, they didn't really believe me when I told them. That always made me feel good that my plastic surgery was a good job.
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My mammography center just sent me a letter saying that my results showed that I do not have dense breasts. This is completely opposite from what they told me last year. Can breast density change that quickly after chemo, radiation, tamoxifen and menopause?
(Edited to add tamoxifen to the mix! All of those things happened during this year.)
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I had surgery Tuesday and part of the pathology came back.....My results are different than initial biopsy patholgy. I am 98% ER+ and 40-50% PR + ( not sure why a range fot the PR and an exact % for ER. My initial ki67 was low Andy now it’s high. I was luminal a and now I am luminal b
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HPFULL, how did they determine you were luminal b? Ki-67 is very unpredictable hope they aren't basing conclusions on that. The worrisome part maybe a positive node.
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the BS said the size made it luminal b. He said the 1 node did have cancer but not enough to count. I was told that my proliferation rate was high
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The size, ok. My mo said they don't classify luminal a vs b in their labs. He said what made mine dangerous was the total lack of progesterone receptors. Good luck and happy holidays.
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Hi all. Need responses ASAP I’m headed to my 6-mo checkup with my Medical Oncologist in an hour or so (December 26) Doing well on my letrozole and feeling great. BUT as a Single Receptor, I worry about distant recurrence and wonder what questions should I ask my MO about screenings and labs and other precautionary testing. I don’t want to wait for symptoms to appear before scanning for METs. Anyway what else should I be asking?
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hey there Patsy. My MO follows the current guidelines. No tumor markers etc. Its a bit unsettling to not be "monitored" with labs but evidence doesnt support that doing so catches recurrence any earlier. I'm glad you are feeling well. Let us know how your appt goes. Happy New Year! Deb
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