Breaking Research News from sources other than Breastcancer.org
I watch for research news on breast cancer, treatments, etc., and frequently see interesting articles. There is a topic on BCO called "Breaking Research News from Breastcancer.org." One of the moderators suggested that another topic might be appropriate for posting links and synopses of reports on research found elsewhere. So here it is! Please post links to reports on research form reliable sources. Thanks for sharing!
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Intratumoral Injection of c-Met CAR T Cells in Metastatic Breast Cancer
http://www.practiceupdate.com/c/60815/67/13/?elsca...
In patients with metastatic breast cancer, intratumoral injections of mRNA c-Met-CAR T cells evoked a tumor-specific inflammatory response and were well-tolerated.
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GoldenGirls posted this link elsewhere. So fascinating, I have to re-post:
Article online (Baltimore Sun): http://www.baltimoresun.com/health/bs-hs-cancer-trigger-20170625-story.html
Johns Hopkins researchers say they've unlocked key to cancer metastasis and how to slow it
Many researchers believe metastasis happens after the primary tumor reaches a certain size, but Jayatilaka found it was the tumor's density that determined when it would metastasize. The study was published online May 26 (2017) in the journal Nature Communications.
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Over-the-counter decongestant found to be effective inhibitor of tumor stroma
https://www.news-medical.net/news/20171120/Over-th...
Epigenetic editing in healthy breast cells can set off chain reaction for tumor initiation
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Wonder if anyone else is reading these? Here's another that I found interesting to me:
'Chemo brain' may start as tumors form and develop, suggests study
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Replacing lymph nodes to ease painful legacy of cancer care
https://apnews.com/2044b48832ec48179dfd33d790785e9...
"...replacing under-arm lymph nodes lost in cancer surgery — ... a small but growing number of hospitals offer microsurgical attempts at relief from lymphedema..."
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Hi, Lumpie. Yes - I'm following this thread with interest. I try to stay up on things and yet you're coming up with studies that rarely overlap with what I've already found, so thank you for a valuable contribution.
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Cancer breakthrough: Nanoparticles used to detect micro tumors
https://www.medicalnewstoday.com/articles/320338.p...
(Now if they will just do something about those micro tumors!)
Hopeful: so glad to know that you are following! This list is not at all systematic... just interesting stuff I run across. I hope it will be of interest to others, too... and maybe inspire hope!
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New research that looks at the long-term effects of chemotherapy on breast cancer survivors finds it weakens parts of the immune system for at least 9 months after treatment.
https://www.medicalnewstoday.com/articles/305566.p...
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Vitamin C can target and kill cancer stem cells, study shows
https://www.medicalnewstoday.com/articles/316334.p...
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RE: cancer and Vit C. Would like to know how they conducted the research? Was a supplement taken by mouth, or was it all in-lab using petrie dishes, etc. instead?
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Lumpie, here is a related article: http://ucsdnews.ucsd.edu/pressrelease/drug_suppresses_spread_of_breast_cancer_caused_by_stem_like_cells
Clair, these are NOT human studies being conducted. These are cell line studies, i.e. petri dishes. They are trying to model pathways and see if their hypothesis holds up. Very early stages.
An important distinction to make is that these "stem-like cells" are rare, and don't appear in most bc. This won't be an avenue of treatment for some time as it is in the patient-derived cell line and mouse model research stage. Very interesting, but shouldn't impact anyone's care in the very near future.
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I find this proof of concept study interesting as well. Hopefully, they'll sufficiently power a study with long enough follow up time to make this generalizable. I keep seeing lots of small studies with short follow up duration. They are intriguing, but not sure if they are all being followed by larger ones.
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I agree, MTwoman. It seems at times as though there's a lot of 'churn,' a lot that's kind of sort of in the pipeline but rarely coming into play as far as treatment, risk prediction/reduction, etc.
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Here's a link to the Vitamin C study abstract. A PDF is available without charge.
http://www.oncotarget.com/index.php?journal=oncota...
Yes, looks like petri dish stage. I agree, it can be discouraging that it can be a LONG pipeline to a useful treatment for us humans! With so much seemingly promising research, it sometimes feels like little comes out the other end of that pipe!
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Thanks Lumpie, really smart people doing exciting research. I do hope that it moves into the stage with actual people at some point!
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that IS more promising. The largest study so far has only had 547 women, so it does need some more work. "Results suggest they someday may help reveal" is a nice way of impressing it's potential. So glad that so much research continues to show promise
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Here's an interesting round up from SABCS:
I found discussion point 5 particularly interesting but others may find useful nuggets in there, too.
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Hopeful, this is helpful for me. I had three years of reclast infusion, no sides, and upset that I didn’t get one this year. If only my doctor had explained. Thank you
“Similarly, another study looked at the duration of bisphosphonates not just as bone preservation agents but also as adjuvant therapy for breast cancer. The study showed that the duration of 2 years was just as good as 5 years. So again, that would be an important observation that should make its way to the clinic and reduce the side effects of these agents while achieving the same benefit.“.0 -
Catching up in the midst of the holidays....
The article above makes note of 1) "the use of acupuncture for aromatase inhibitor-induced joint stiffness and pain." and 2) "protecting the ovaries of women undergoing chemotherapy...to preserve fertility" which will be of interest to some readers.
Here are others I found interesting:
Prior Systemic Treatment Increases Somatic Mutation Incidence in MBC
http://www.practiceupdate.com/c/61989/67/13/?elsca...
Current Status of Checkpoint Inhibitors in Breast Cancer (in heavily pretreated triple-negative breast cancer)
http://www.practiceupdate.com/c/62055/67/13/?elsca...
FDA Clears Stereotactic Radiotherapy System for Use in Treating Breast Cancer
"...patients will have access to a treatment option that provides greater accuracy in delivering radiation therapy to breast tumors while saving surrounding breast tissue,"
http://www.practiceupdate.com/c/62331/67/13/?elsca...
https://www.news-medical.net/news/20171222/Novel-r...
https://www.news-medical.net/news/20171226/Novel-G...
Study finds new marker to detect breast cancer
https://www.news-medical.net/news/20171222/Study-f...
Loss of specific protein makes breast cancers more aggressive, resistant to chemotherapy
https://www.news-medical.net/news/20171221/Loss-of...
Study elucidates mechanism behind metabolic vulnerability of some breast tumors
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Inherently controversial - but interesting to contemplate from a public health perspective....
Third of breast cancer patients treated unnecessarily, study says
http://www.cnn.com/2017/01/10/health/breast-cancer...
Doing more harm than good? Epidemic of screening burdens nation's older patients
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Lumpie, titles that sensationalize a study are frustrating to me. From the second article you cited above ("third of bc patients treated unnecessarily"), "The American College of Radiology, which strongly supports breast cancer screenings, acknowledges that mammograms lead some women to be treated unnecessarily, but said the problem is much less common than the new study suggests. Another study from Denmark -- whose national health program keeps detailed records -- estimated the overdiagnosis rates at only 2.3 percent." So there is active debate about how many women are "over treated". For my part, I'd rather be one of the over treated than someone who didn't get caught early, and so was under treated (or treated too late).
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MTwoman: I agree - on both counts. Plenty of sensationalizing in the press ... whether it's snow storms or mammograms! I do kind of struggle with the other ... I "get it" that, from a public health perspective, not all screening is "productive." (I also get it that if cancer is not found in time to be treated, "you're the one who's dead" as a friend so indelicately put it.) I think what irks me is that "they" too often think that the public can't or won't think through factual information (if) clearly presented and make an informed decision about what screening to pursue. I appreciate that the matter is being studied and analyzed. I appreciate the benefit of additional data. Although it is not advantageous, I even appreciate knowing that, as a young-ish woman with dense breasts, mammograms are/were not a very effective screening tool for me. (Too bad my doctors never told me this!) But I also agree that it should be my choice, in consultation with my doctor, whether I pursue this screening. And ... even though a mammogram did not find my cancer.... I think I would choose to be screened. In my experience, I know my body. It's not foolproof, but if I have a sense that screening is needed, I probably should not ignore it. I note who is being targeted for extra screening services: "executive health" program participants. Perhaps these are fools being parted from their money. Perhaps they are getting all the 'health' money can buy. Possibly both. Perhaps what should be studied is the process of making the choice. I think they would find that some people are risk averse. Others seem to be positively health averse. And then, I guess, there is everybody else.
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Eeeekkk! No alcohol? No sausage or bacon?!? Shoot me now!
On a more positive note, this article says cold medicine may save us (just goes to show... you never know!):
Over-the-counter decongestant found to be effective inhibitor of tumor stroma
https://www.news-medical.net/news/20171120/Over-th...
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Heard on the news today about promising results from first human trials of personalized cancer vaccines. Here's the link to a short overview: Personalized Cancer Vaccines
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https://cancercompass.com/cancer-news/article/6026...
New Cancer Drug Shows Promise Against Wide Range of Tumors
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Hospitals Create Drug Company to Fight High Drug Prices
https://www.healthline.com/health-news/hospitals-c...0
