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Breaking Research News from sources other than Breastcancer.org

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  • zen1028
    zen1028 Member Posts: 82
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    Just hoping we have "something" out in the next 5 yrs. Not just for us but all that could be impacted in the future.

    https://www.anixa.com/pipeline

  • morrigan2575
    morrigan2575 Member Posts: 801
    edited June 1
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    "How did your trial work out! It's my understanding that the vaccines being touted these days are for triple negative and nothing for ER positive, but not totally sure. "

    So far, so good. I'm 4 years out from my DMX and 2 years out from completing the trial. It was a Phase 2 trial, only 115 participants and obviously still early in the cycle, the intention was as a prevention for recurrence, not prevention for cancer at all.

    My understanding is the preliminary data is very promising but, nothing has been published yet (probably in 2-3 years).

    The vaccine target HER2+ breast cancer, there are quite a few vaccines in trial for Triple Negative and HER2+ but, I do agree I haven't seen much for ER+/HER-

  • threetree
    threetree Member Posts: 1,470
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    Morrigan - Thanks for more details re your situation and knowledge of these vaccines. I'm trying to keep something of an eye on what's going on with them.

    Zen - I agree that even if some of us aren't able to benefit, it will be really nice to have something for those down the road. When Bio n Tech created their Covid vaccine, they said they also had some breast cancer things in the works that might be ready in 3-5 years. Well, that was about 3 years ago now, so I'm watching for more from them. I did see where the NHS vaccine being tested (noted in the post a couple/few above this) is connected to Bio n Tech in some way, but apparently breast cancer is not involved at this point.

  • zen1028
    zen1028 Member Posts: 82
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    Found this and sounds like its been "green light" for phase 3 but looks like the company lack funding, which is estimated at 100 million USD. However they are doing a phase 2A basket trial.

    https://www.orbishealthsolutions.com/clinical-trial

    https://abcnews.go.com/Health/melanoma-cancer-vaccine-minimal-side-effects-nearing-phase/story?id=106521186

  • amel_83
    amel_83 Member Posts: 169
    edited June 17
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    Let's hope they find the funding, thank you for the link!

  • amel_83
    amel_83 Member Posts: 169
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    Hi

    I ask here as i can't find the answer i want online...I hope it is ok.

    I though i saw a post saying BRCA mutations can change over the time? To say...test was negative and now it is positive? It is possibile?

    I always tough it was a mutation about myself, not about the cancer genetic, am i right?

    What i think i read, is that somebody did a test and was BRCA negative, than she get retested years later and the test was positive.

    I though it was weird, and that i will just check it online, but than i couldn't find nothing about, so it appear not to be the case...and i can't even find the original post where i read it.

    May I just confused mutation names,or somebody heard something similar?

  • aprilgirl1
    aprilgirl1 Member Posts: 787
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    @amel_83 there are mutations we are born with called germline mutations . There are also somatic mutations that we can acquire during treatment . Brca can be both types . @candy-678 has brca as a somatic mutation .

  • amel_83
    amel_83 Member Posts: 169
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    Ok, this is what i was trying to find! Thank you very much, i understand now

  • candy-678
    candy-678 Member Posts: 4,144
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    I had the genetic testing (blood sample) when first diagnosed with breast cancer. For my family. It was BRCA negative. But, 3 months later we found out it was in the liver too- - went from labeled Stage 2 to Stage 4. I had a liver biopsy at that time to make sure it was breast cancer mets, and they did genomic testing on the liver sample. It showed BRCA positive. I was put on Lynparza (for the BRCA) after Ibrance stopped working, and I have been on Lynparza almost 3 years now and going well.

  • amel_83
    amel_83 Member Posts: 169
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    @candy-678

    Thank you very much for your experience, and I'm happy Lyparza work so well for you!

    I will ask my MO to test it again if i will have a biopsy

  • zen1028
    zen1028 Member Posts: 82
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