Breaking Research News from sources other than Breastcancer.org
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Let's hope they find the funding, thank you for the link!
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Hi
I ask here as i can't find the answer i want online...I hope it is ok.
I though i saw a post saying BRCA mutations can change over the time? To say...test was negative and now it is positive? It is possibile?
I always tough it was a mutation about myself, not about the cancer genetic, am i right?
What i think i read, is that somebody did a test and was BRCA negative, than she get retested years later and the test was positive.
I though it was weird, and that i will just check it online, but than i couldn't find nothing about, so it appear not to be the case...and i can't even find the original post where i read it.
May I just confused mutation names,or somebody heard something similar?
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@amel_83 there are mutations we are born with called germline mutations . There are also somatic mutations that we can acquire during treatment . Brca can be both types . @candy-678 has brca as a somatic mutation .
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Ok, this is what i was trying to find! Thank you very much, i understand now
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I had the genetic testing (blood sample) when first diagnosed with breast cancer. For my family. It was BRCA negative. But, 3 months later we found out it was in the liver too- - went from labeled Stage 2 to Stage 4. I had a liver biopsy at that time to make sure it was breast cancer mets, and they did genomic testing on the liver sample. It showed BRCA positive. I was put on Lynparza (for the BRCA) after Ibrance stopped working, and I have been on Lynparza almost 3 years now and going well.
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Thank you very much for your experience, and I'm happy Lyparza work so well for you!
I will ask my MO to test it again if i will have a biopsy
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One move vaccine coming to trials…hope this one survives..
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Still at very beginning but interesting:
"One of the drivers of metastasis is miR-10b, a small noncoding RNA implicated in cancer cell invasion, migration, viability, and proliferation. We have developed a nanodrug, termed MN-anti-miR10b, that delivers anti-miR-10b antisense oligomers to cancer cells. In mouse models of metastatic triple-negative breast cancer, MN-anti-miR10b has been shown to prevent onset of metastasis and eliminate existing metastases in combination with chemotherapy, even after treatment has been stopped. Recent studies have implicated miR-10b in conferring stem cell-like properties onto cancer cells, such as chemoresistance. In this study, we show transcriptional evidence that inhibition of miR-10b with MN-anti-miR10b activates developmental processes in cancer cells and that stem-like cancer cells have increased miR-10b expression. We then demonstrate that treatment of breast cancer cells with MN-anti-miR10b reduces their stemness, confirming that these properties make metastatic cells susceptible to the nanodrug actions. Collectively, these findings indicate that inhibition of miR-10b functions to impair breast cancer cell stemness, positioning MN-anti-miR10b as an effective treatment option for stem-like breast cancer subtypes."
https://www.oncotarget.com/article/28641/text/
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Amel - Thanks for posting. I always like to see "what's in the can" even though I have very little hope that any of these will be actually fully developed and ready any time soon. Just glad they haven't given up on looking for new things.
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Threetree me to, i just like to give a look at them, from one things may come another, and if something work really well with low toxicity they may be able to put it out a little sooner, i wonder...
But sometimes i read something too cool, especially on Genengnews, but than I get so bombed out it all just look so far away...
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This look promising for who have brain mets: Bria-imt plus immunotherapy
The patient’s temporal lobe tumor was no longer detectable via imaging taken at 8 and 11 months of treatment, and their eye-bulging orbital lesion has continued to shrink. This patient also experienced a sustained decrease in tumor markers, which confirmed the imaging results showing tumor reduction.
Previously, at 2 months, this patient, who had progressed on 8 prior regimens, including antibody-drug conjugate therapy, had achieved an initial partial response in the brain lesion, and had no detectable disease following 8 and 11 months of treatment. At the time of the data release, the patient had completed 17 cycles of study treatment, had been enrolled in the study for 12 months, and continued to receive treatment with the Bria-IMT regimen.
https://www.onclive.com/view/bria-imt-plus-immunotherapy-shows-early-promise-in-breast-cancer-brain-metastasis
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Triple Viral Infections in Advanced Breast Cancer: Insights from a Three-Case Report and Literature Review
https://www.mdpi.com/2075-4418/15/1/51
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Hi
Just stumbled across this article. It is not related to breast cancer but colorectal cancer. However the implications are enormous. Just think, if this can be achieved, and applied to all cancers, WOW. We could be 'normal' again.
"KAIST Develops Foundational Technology to Revert Cancer Cells to Normal Cells"
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Fascinating for sure! From what I read, I don't see why it wouldn't work on all kinds of cancers, since they make a "digital twin" of things. Like all of these discoveries though, it looks like it is in it's infancy and would have a long way to go before becoming anything practical for any of us. Thanks for posting this.
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