Breaking Research News from sources other than Breastcancer.org
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Yes Lumpie, i noticed that you were MIA about ten days a little back and wa worried too. Glad your scans are stable!
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Thanks for the update Lumpie and all you do here!
I googled confidence interval for dummies and I still don't understand what it means. Does anyone happy to have an easy explanation? I wish my local community college had a class on how to interpret medical studies.
from the BRCA study link above...
Results: For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with breast cancer risk, except smoking for more than 5 years before a first full-term pregnancy (FFTP) when compared with parous women who never smoked. For BRCA1 mutation carriers, the HR from retrospective analysis (HRR) was 1.19 [95% confidence interval (CI), 1.02–1.39] and the HR from prospective analysis (HRP) was 1.36 (95% CI, 0.99–1.87). For BRCA2 mutation carriers, smoking for more than 5 years before an FFTP showed an association of a similar magnitude, but the confidence limits were wider (HRR = 1.25; 95% CI, 1.01–1.55 and HRP = 1.30; 95% CI, 0.83–2.01). For both carrier groups, alcohol consumption was not associated with breast cancer risk.
Conclusions: The finding that smoking during the prereproductive years increases breast cancer risk for mutation carriers warrants further investigation.
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2019whatayear - thanks!
Regarding confidence intervals... as you note, it is a statistics term. I actually took stats not too long ago - but it is hardly my strong suit. Long story short.... and probably over simplified.... if you have a bell curve (not sure if I can insert a pic but it comes right up if you google it), the confidence interval states how confident you are that all relevant values are in the part of the graph where you think they should be. At least for scientific research, the confidence interval is almost always between 95% and 99%. The higher the number, the more confident you are about your results. So with a 95% confidence interval, you are 95% confident that the values fall where expected. For peer reviewed, scientific research, the confidence intervals are going to be very high. 95% or higher. I think I usually see 95%.
When reading high quality, peer reviewed research, I don't get real bogged down in the CI number. It is going to be high and it's not like I am going to (or able to!) re-do the math to confirm it.
I hope that helps.
PS: That's a good tip for your community college or local adult education program...or maybe even a library if they have classes, seminars or talks on topics!
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Lumpie, so glad to hear you're doing pretty well! I also noticed you hadn't posted something here for a while, but I saw you were active on other boards.
Here's a new tidbit:
Could beta-blockers slow the spread of cancer?
New research from Monash University has suggested that anti-stress drugs, known as beta-blockers, could slow the spread of cancer in the body.
The study, which was published in Clinical Cancer Research, marks the first ever study marking that beta-blockers stop cancer cells spreading through the body in women with breast cancer.
http://www.pharmatimes.com/news/could_beta-blockers_slow_the_spread_of_cancer_1323268
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Researchers uncover two-drug combo that halts the growth of [HER2] cancer cells
DALLAS - Jan. 23, 2020 - UT Southwestern Simmons Cancer Center researchers have discovered a two-drug combo [everolimus added to neratinib] that halts the growth of cancer cells that carry HER2 mutations.
The findings, published today in the journal Cancer Cell, were prompted by the observation that, after an initial response, patients with cancers harboring HER2 mutations eventually develop resistance to a promising new cancer drug [neratinib] currently in clinical trials...
Sudhan says the combination of neratinib and everolimus worked in cell lines, organoids established from patient-derived tumors, and in mice harboring HER2 mutant tumors. The next step will be testing this two-drug combo in humans.
https://www.eurekalert.org/pub_releases/2020-01/usmc-rut012320.php
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Insurance Status Helps Explain Racial Disparities in Cancer Diagnosis
From blog of Dr. Francis Collins, Director of the National Institutes of Health:
A new NIH-funded study of more than 175,000 U.S. women diagnosed with breast cancer from 2010-2016 has found that nearly half of the troubling disparity in breast cancer detection can be traced to lack of adequate health insurance. The findings suggest that improving insurance coverage may help to increase early detection and thereby reduce the disproportionate number of breast cancer deaths among minority women.
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Whew Lumpie, hope you managed to get the washer fixed / replaced? Can’t have you being so smelly we whiff you in Scotland!
It’s a bit of a thing when you are prolific and sound, so folk start to depend on you. That’s also too much and you need to be able to check out and have a breather!
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Thanks for taking time to explain Lumpie.
I am going to contact my library and suggest a program on how to understand medical news/read medical studies.
:-)
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Lumpie, you deserve all the breaks you want. We so appreciate you and all the wonderful information shared here.
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Lumpie, thank you for taking a break when you need to. We sure appreciate all you do here and want you to take good care of yourself.
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Night Shift Work-A Risk Factor for Breast Cancer
The case-control study was conducted from 2015-2019 in the Łódź region [in Poland]... Even after considering the effect of other possible cancer factors (like high BMI, smoking, early menstruation, late menopause, pregnancy history, age, place of living, education), the odds of developing cancer were twice as high in the group of shift workers (OR = 2.20 (95% CI: 1.57; 3.08)).
https://www.physiciansweekly.com/night-shift-work-a-risk-factor-for-breast-cancer/
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Magnetized Particles Show Live Metabolic Activity of Breast Cancer
Researchers at Cancer Research UK Cambridge Institute and the Department of Radiology at the University of Cambridge are now reporting in Proceedings of the National Academy of Sciences that they've used magnetized particles to image the actual metabolic activity of breast cancer tumors. This may provide a relatively accessible new way of categorizing tumors, allowing for more accurate decision making during diagnosis and subsequent treatment, saving lives in the process and minimizing unwarranted therapies.
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Why eating yogurt may help lessen the risk of breast cancer
One of the causes of breast cancer may be inflammation triggered by harmful bacteria suggest researchers. Scientists advise consuming natural yogurt, which contains beneficial bacteria which dampens inflammation and which is similar to the bacteria found in breastfeeding mothers. Their suggestion is that this bacteria is protective because breast feeding reduces the risk of breast cancer. The consumption of yogurt is also associated with a reduction in the risk of breast cancer.
https://www.sciencedaily.com/releases/2020/01/200124073857.htm
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key being NATURAL yogurt
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Help me out with a definition of "natural yogurt." How is that different? What makes it "natural?"
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According to my google it is plain yogurt. No added anything
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Honestly, I was hesitant to post the yogurt article, because it's just about a paper speculating on the reason *why* yogurt seems to reduce bc risk (published in the journal "Medical Hypotheses"). But articles based on that paper popped up in a lot of places sounding like there was new yogurt evidence (which I did not see) so I posted a link to the article that seemed clearest. If you want to look at potentially relevant yogurt studies, the food for breast cancer site references several: https://foodforbreastcancer.com/foods/low-fat-yogurt.
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Thanks, whatayear. Plain it is, along with berries and some ground flaxseed for me. Alas, it didn't keep me from getting cancer! Nor did all the other reasons I woulda been pegged as "low risk."
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I raise a fist in anger on your behalf Mountain Mia! IF only we could return our cancer like a pair of shoes to the store. Yeah, these boobs just didn't work out, I would like to return them and get my clean bill of health back.. tyvm!
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Single dose of psychedelic drug eased cancer patients' anxiety, depression for years
Nearly five years after a group of cancer patients were given a single dose of a psychedelic drug [psilocybin] to ease depression and anxiety, new research finds that many of them are still feeling the positive effects...
Dr. Stephen Ross, director of addiction psychiatry at New York University's Langone Medical Center who led the 2016 study and co-authored the new research, said the results of the latest study are "mind-boggling."
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Natural Body Protein Found to Suppress Breast Cancer Metastasis
A protein naturally produced in the body has been found to suppress breast cancer metastasis in animal models of human tumors, according to a research study ("The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing") led by a team at Baylor College of Medicine. The team also found that high levels of this protein, AKAP8, predicts a better survival for breast cancer patients. Their work appears in Nature Communications. The findings show that AKAP8 inhibits metastasis by interfering with the production of proteins that promote metastatic behavior in cells and suggest strategies that may help treat metastatic cancer in the future.
https://www.genengnews.com/news/natural-body-protein-found-to-suppress-breast-cancer-metastasis/
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Novel Drug May Reverse Breast Cancer Hormone Therapy Resistance
SFX-01 – inspired by a natural plant-derived compound called sulforaphane, which was first discovered in cruciferous vegetables such as rocket, broccoli and kale – has recently been shown in a clinical trial to delay the progression of incurable secondary breast cancer in women whose disease has already developed resistance to hormone therapy.
In a new study led by Dr Bruno Simões, Dr Sacha Howell and Professor Rob Clarke at the University of Manchester, researchers investigated the effect of SFX-01 alone, or in combination with tamoxifen or fulvestrant, in patient samples and in mice to understand how the drug works and how it can be best used to treat breast cancer.
They found that SFX-01 reduced the ability of specialized cells called breast cancer stem cells to form tumors in mice, with the drug also reducing the ability of breast cancer cells to form secondary tumors in the mice's lungs.0 -
A targeted therapy for triple negative breast cancer may lie [in] existing drugs
- Researchers identified two proteins -- mutant tumor protein 53 (mtp53) and poly-ADP-Polymerase (PARP) -- that are present and interacting with DNA during the replication process in [most] patients with triple negative breast cancer.
- Suppressing these proteins through a combination of existing PARP-inhibiting therapies [talazoparib and temozolomide] could be an effective way to interrupt the development of triple negative breast cancer cells and offer the first targeted treatment for this form of the disease.
- The findings may also reclassify triple negative breast cancer as a different form of the disease that can be treated by combining already existing therapies.
https://eurekalert.org/pub_releases/2020-01/asrc-att012920.php
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I had this technique for my lumpectomy. It was called a savi scout. It was inserted just like a tumor marker during biopsy a day or two before my surgery.
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The Expression Level of HJURP has an Independent Prognostic Impact and Predicts the Sensitivity to Radiotherapy in Breast Cancer
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Choice of anesthesia may change metastatic process of breast cancer
Jun Lin, MD, PhD, of the Department of Anesthesiology in the Renaissance School of Medicine at Stony Brook University, and colleagues found that sevoflurane anesthesia leads to more metastatic burden in the lung after breast tumor resecting surgery than propofol in laboratory models.
The study findings may serve as a guide to design clinical trials for clinicians to optimize anesthesia choice for breast cancer surgery in order to achieve best long-term outcomes.
Source:
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CytoDyn Announces Stunning Results from Clinical Trials Evaluating mTNBC and MBC with Leronlimab and will Request an Emergency Type C Meeting with FDA to Enroll 50 Awaiting Patients with a Serious Solid Tumor Cancer Condition
[BTW, I posted about earlier results a month ago.]
Third patient data supports leronlimab (PRO 140) as a potential treatment option for metastatic triple-negative breast cancer (mTNBC) and metastatic breast cancer (MBC). Patient CTC dropped to zero after 2 weeks of leronlimab treatment, same as the first patient on leronlimab
https://finance.yahoo.com/news/cytodyn-announces-stunning-results-clinical-110010381.html
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Wow, that last one is a stunner! Something to clearly watch. Thanks much.
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"Choice of anesthesia may change metastatic process of breast cancer" barely gave any info and what it gave didn't make sense. I wonder if there's an actual article on this somewhere else?
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Look up ketorolac.... there is a lot of info on it being a good anesthesia choice that discourages mets.
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