Breaking Research News from sources other than Breastcancer.org
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my two cents - not that I’m a expert but — some drugs look very promising in animal studies but the researchers can’t get a drug company or other funding entity interested and the project goes nowhere
In the case of ERSO, Bayer has put lots of money behind it doesn’t that mean something? At the very least, human trials will go forward, even if the result is not positive, there will be an answer one way or another
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GoKale, Of course it could be terrific in humans but there have been many treatments that work fabulously in mice and end up disappointing in humans (indeed we can cure cancer in mice). Mouse models of human disease are being improved but have problems recreating the mechanism of metastatic spread to various organs, and also do not recapitulate the tumor-immune system interactions that protect tumors in humans, so anyway my sense was ERSO data looked good but its in early days, and there are hella lot of drugs that fall into that category. For example, I was excited about the discovery of a universal cancer neoantigen, which should allow CAR-T to work for any cancer, but there's still no news for any clinical trials and its been two years now. Similarly, very excited about the IL19 decoy drug that in mice makes immunotherapy work amazingly on all kinds of cold tumors, they promised trials were coming but there's been no news for a couple years.
I hope you learn some insider information, and I'd be thrilled if it works- sometimes it seems these companies need people pushing them from the outside
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The FDA strengthened safety standards for breast implants
The agency will require manufacturers and plastic surgeons to warn prospective patients of possible complications, The {Washington} Post's Katie Shepherd reports.
Key context: The requirements come after years of complaints from tens of thousands of women who received breast implants and later had brain fog, fatigue and other health issues, known as "breast implant illness."
Providers will now be required to walk patients through a checklist of risks. It will warn of cancer linked to the implants and patients will be required to affirm that they understand that breast implants don't last a lifetime.
https://www.washingtonpost.com/health/2021/10/27/f...
{Complete article may be behind a pay wall... not sure...}
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Lumpie, so good to see you back. Thank you for the link. So helpful for me since I am considering the next step to remove the implants.
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Thank you, LilyIsHere! very glad I could pop in. Schedule has been hectic lately but I am trying to ad a bit here and there. I get notifications of posts and enjoy following the postings/discussion.
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NIH Director Francis Collins On Covid, Faith, And The Future Of Medical Research In The U.S.
Doctor Francis Collins is stepping down as director of the National Institutes of Health after 12 years. He reflects on his legacy and his agency's efforts in the fight against COVID-19.
https://dianerehm.org/audio/#/shows/2021-10-22/nih-director-francis-collins-on-covid-faith-and-the-future-of-medical-research-in-the-u-s/116534
@{@45 minute interview by Diane Rehm. Not exclusively, or even primarily, about cancer research, but may be of interest to those interested in NIH, medical research and some of the humans behind this work. No charge for access. You'll have to copy and paste the *full* web address to get to the right episode.}
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TNBC Vaccine to prevent recurrences: trial
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Lumpie, you were missed! Glad to see you posting again. I love this thread as I learn so much - I keep my MO on his toes…LOL
Santabarbarian, that is an interesting trial. I hope it proves to be a success!
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I join the chorus celebrating Lumpie. I missed her posts. Thank you Lumpie. Glad to see you back and I hope all is well with you.
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Study: Eating nuts improves survival rate in breast cancer
A study in the International Journal of Cancer found that breast cancer survivors who consumed more than one-half ounce of nuts a week had 94% five-year survival and disease-free survival rates, while those who didn't consume nuts regularly only had an 89% five-year survival rate and an 86% disease-free survival rate. The findings also revealed that 94% of the participants who ate nuts regularly did not report return of their breast cancer within half a decade of recovery.
Full Story: United Press Internationalhttps://www.upi.com/Health_News/2021/10/20/breast-cancer-nuts-survival-study/1631634735622/
https://onlinelibrary.wiley.com/doi/10.1002/ijc.33824
{Golly. That's a plus. The study only evaluated 5 years and notes that long term study is needed. Free access to both reporting and to the journal article. (I don't know why it's still underlining....) }
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You are all too kind and generous with the very nice comments! It is good to be missed. Thank you!
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I love nuts but they are expensive and not very filling despite being highly caloric. They're basically dessert for health-concscious fancy people.
My first impulse was that nuts are standing here as a proxy for socio-economic status and it was interesting to me that when they adjusted by income, nuts actually made no impact on overall survival.
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Only a 1/2 oz of nuts a week isn't much. I've been eating 2 tblsp a week for some time & it has helped lower my cholesterol. Of course almonds & pistachios are better for you than cashew nuts. And naturally un-salted are better too. Sometimes they are dessert, but just as often I throw them in a salad.
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I remember hearing that walnuts, specifically, may be good for breast cancer patients. Here’s a mouse study -
https://pubmed.ncbi.nlm.nih.gov/30979659/
And I think there are other studies with walnuts
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I have been eating nuts every day for many years and I keep them at work, car, home even though my kids are allergic to tree nuts. I even mix nuts with honey and eat them as dessert. Since starting letrozole I am finding them difficult to digest and I don't eat as much anymore.
Salamandra, you can find them cheap at Costco.
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Agree about the Costco prices. Yes walnuts are high on all the 'good' lists. Unfortunately I am allergic to walnuts & macadamia nuts - but I eat all the rest.
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Walnuts are good for your brain as well. Here in Ky you can find walnuts for free if you want to go to the trouble to crack them open yourself.
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Ooohh yes good to see you Lumpie and a real pic of Cure-ious!
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I'm wondering, in these instances where funding a human trial is an issue, does Metavivor come in to help fund? I give 2% of my net commissions to a handful of charities and of course Metavivor is one and the next one up for a check.
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I received a response from Bayer about the emails I have been sending with requests for ErSO clinical trials:
Thank you for your inquiry regarding one of our drugs in development, ErSO. As you may have read, it has shown promising results in pre-clinical models of breast cancer. However, before it can be tried in humans, additional safety tests (such as in primates) must be undertaken, and that is where the compound currently is in development. We try to move our compounds through development as quickly as possible, but at the same time we have to take the prudent steps to ensure that the compounds are safe and provide the potential benefits we are striving to achieve (and thus the tests in other species such as primates). Because of these necessary steps the drug is not currently available for trials in humans. However, we hope to be able to provide an update on the status of the program before the end of the year.
If you would like to contact me in a 6-8 weeks, I may be able to give you a more definitive schedule.
You should know that Bayer posts its human clinical trials for all of its drugs on clinicaltrials.gov and that is another source for ongoing (or soon to start) clinical trials.
I hope that your doctors find ways to control your cancer in the meantime.
Sincerely,
Joseph Germino, MD, PhD
Vice President USMA
Bayer Healthcare
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WOW, Kale!! Great job, and thanks so much!
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Go Kale!
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GoKale,
Wow, it's wonderful he responded to you. Thanks for sharing.
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GoKale, thank you so much for taking the initiative on this. Wonderful that you received what appears to be a personalized response. Can you share the email address you used to contact Mr. Germino?
Praying that ErSO reaches human trial phase soon and that it actually works! I'm very cautiously optimistic.
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MoCoGram - here is the email address for Dr. Germino
joseph_f.germino@bayer.com
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Someone asked about METAvivor funding for research. METAvivor has a research funding application process. It takes place once or twice a year. Petitioners must complete a grant application. This is typical in the grant application/research "space." Applicants are scored and ranked by a scientific team and by patient advocates team. Scoring relates to chance of success and potential impact. A board makes final decisions about awards. Those interested in applying can find more info on the METAvivor website.
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Sharing this update from the American Cancer Society's Cancer Action Network:
Exciting news! We have recently released some initial findings of our last Survivor Views survey, which focuses on patient experiences with telehealth and issues around clinical trial participation. As noted by ACS CAN president Lisa Lacasse in today's press release, "These data suggest we have a real opportunity to make clinical trial participation easier for all patients by removing barriers to participation, including through the use of telehealth technologies and reducing out-of-pocket costs."
To all those who responded to our Summer 2021 survey, THANK YOU! You've contributed your voice to our mission of improving the lives of cancer patients and survivors. With the Survivor Views project, we do this by making sure you are heard by the decision makers shaping health policy.
If you haven't yet responded to our current survey, which covers topics like paid medical leave for patients and caregivers, please click the following link to respond by November 15th:
https://survey.us.confirmit.com/wix/p925353504545.aspx
{If you are interested in signing up for the ACS Cancer Action Network, you can do so here:
The group does both advocacy and fundraising. You can pick and choose your level of participation.}
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A very interesting episode (there are more - please check): https://www.ourmbclife.org/episodes/rtac-lin-parso...
Also lot's of useful information and articles.
Saulius
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Thanks for that link Saulius! Great conversation.
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https://investor.lilly.com/news-releases/news-rele...
FDA has approved Verzenio for HR+ HER2 -, node positive high-risk early breast cancer
"This subgroup analysis (N=2,003) included patients with ≥4 positive axillary lymph nodes (ALN), or 1-3 positive ALN with either Grade 3 disease and/or tumor size ≥5 cm, and whose tumors had a Ki-67 score of ≥20%. There was also a statistically significant improvement in IDFS for this pre-specified subgroup of patients receiving Verzenio plus ET compared to those who received ET alone."
"The number of IDFS events at the time of this analysis was 104 with Verzenio plus ET compared to 158 with ET alone."
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