Are you currently (or have you been) in a Clinical Trial?
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Well, here is something exciting, just published in Nature Communications:
This is preclinical (studies in mice)- researchers treated TNBC with radiation and immunotherapy (anti-CTLA4) and saw T cells enter the tumors, but nothing much else happened to shrink the tumors. They then added on Keytruda, which didn't help. they then added a CD40 agonist antibody- these antibodies stimulate dendritic cells, which are the first step in the killing of cancer cells- these are cells that eat the tumor cells and extrude cancer proteins on their surface to activate and target nearby T cells. the results were dramatic and most of the tumors went away.The three-pronged therapy resulted in complete or almost complete elimination of targeted tumors, as well as partial control of tumors that were not targeted by the radiation. However, the approach was not effective in eliminating micrometastases that had spread to the lungs. So not a cure but maybe a big step forward to make immunotherapy work in TNBC. A clinical trial is planned for MBC as the next step forward.
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And we have not discussed yet that there was big news in Sept when BioNTech's bispecific PDL1/VEGF antibody beat out Keytruda when combined with chemo as first line treatment for metastatic TNBC…
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Quick question about adding on Celebrex - can I do that if I am on blood thinners? Im desperate for an anti-inflammatory of some, any kind to reduce the hip swelling at night and NSAIDs are a no go (look, Ill admit to using Voltaren gel and when I really could care less, Ill sneak two Advil, which do more for me than all the stupid opiates) due to bleed risk. Onc mentioned Celebrex possibly waaaaaayyy back in January but that got lost amongst the other issues this year.
Ive also not been offered any sort of clinical trial but Im still bone only and my cancer center works pretty exclusively with AZ. I went through some of the back pages of this thread to October, but it doesnt look like there is anything good testing in the UK coming along for ER+ /HER2+ cancers?
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Sondra- Celebrex is an NSAID, so probably not good with blood thinners? - you might try MSM supplement as a safe anti-inflammatory?
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Dear Cureious - regarding the Patina trial: yes, it is for HR+/HER2+, and the choice to block additionally ER was so obvious but it needed proof. Some patients that I know get tamoxifen in addition to HP but getting palbocyclib is something much better. Everyone was afraid triplet would cause huge SE, as for some palbocyclib alone is not a gift but this study did indeed prove that it is not the case. Human body is amazing and so unpredictable that it is really hard to know what would be that universal magic bullet. I am also very happy that treatments start to interchange - HR people benefit from HER2 treatments, and HER2 people - from HR! That is the way to go! Hugs,
Saulius
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2023: The median cost for a pivotal (i.e., phase III) clinical trial is $48 million, with an interquartile range of $20 million to $102 million. The same study calculated the average cost per patient to be $41,413 in pivotal clinical trials….
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MommaCJ- I wonder if you are still considering immunotherapy? A PDL1 score of 100% is super-rare! I forget if the cancer is ER-positive or - negative, and did they measure the tumor mutation burden. I was thinking of you when I read about a bispecific PDL1 antibody (binds to both PDL1 and Her2) that attached to cancer cells through both protein interactions as a result it binds more tightly, is targeted to the cancer more precisely, and is more effective. Stronger than Keytruda with fewer side effects! I was thinking maybe they could use that for Her2-low cancers also?
PS Were there any other mutations that might give a clue as to why the PDL1 levels are so high?
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@cure-ious thank you for the 2 articles on news highlighting research with TNBC. As a TNBC / MBC gal, I am particularly on the lookout for clinical trials in this area. I am working with a doctor at MSK, who is looking should my current treatment stop working. So far so good though, love learning and appreciate your knowledge, and everyone’s comments and contributions here. Happy holidays everyone.
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Sondraf
I have been on Celebrex (100mg 2x/day) for 2.5 years for arthritis pain. Almost 2 months ago, after reading Chicagoan's and cure-ious' discussions about it, I added 2000 mg of MSM with my MO's approval. I take it in capsule form as I never believe the ads that say to mix it in a liquid and you won't taste it. I think that I'm beginning to feel some subtle improvement in energy levels and decrease in skeletal pain. I have been on Kisqali/faslodex/xgeva for 2.5 years and hope to stay on it longer - fingers crossed for February scans - as I am able to lead what I think is an active, normal life for a 74 year old.
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