Kadcyla side effects
Hi,
Like to know how tolerable Kadcyla is and it’s side effects.
Appreciate any comments.?
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Hi all!
I'm hoping others will revive the Kadcyla side effects thread. I was switched from Herceptin/Perjeta due to residual cancer post mastectomy. I had my first Kadcyla infusion (with decadron and zofran IV) three weeks ago and experienced the following side effects:
3 days after - thigh soreness, fatigue
4 - 6 days after - terrible headache X3 days with strong nausea
7+ days after - constipation and feeling like my food was not fully digesting, increased reflux, difficulty sleeping, fatigue
I am still having the GI issues. I contacted my oncologist's office and they recommended I drink more fluids (allegedly caused headache), take gas-x and Miralax. I am concerned that I will have worse side effects since I won't be receiving premeds this time.
My breast cancer was HER2 triple positive, stage III. I completed four rounds of AC, followed by 12 rounds of Taxol and five rounds of HP. I underwent bilateral mastectomies with immediate reconstruction about a month ago.
Thank you all for sharing and I am more than happy to answer any questions other may have for me.
-SW
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I did 14 rounds of Kadcyla from October '22 through July '23. I had pretty much the same side effects as @sarawil. Days 4-6 were when I felt the worst. I had GI issues for the entire time, particularly queasiness, indigestion, reflux, and constipation. I took 2 stool softeners daily. Fatigue was an issue, but I don't know if it was the Kadcyla or continued effects of the chemo/surgery that preceded it. I'm on anastrozole now so the fatigue continues! I didn't have headaches, though, and I drank a lot of water. It wasn't the "breeze" that my MO said it would be, but it was definitely easier than chemo. I felt pretty normal a lot of the time.
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