Tried 5 drugs in the lat year, none worked
My mother was first diagnosed with breast cancer in Nov 2014 (Grade II, ER+/PR+/HER2-). She did Chemotherapy (Doxorubicin + Cyclophosphamide + Paclitaxel) followed by radiation
Then years later she found a lump on her left breast Dec 2019 and had surgery to remove it, after which the Dr said she was stage 1 because the cell profile showed that the tumor was margin free. But then "accidentally" (after going to the Dr for constipation) found out she had Metastatic breast cancer March 2020 (Grade III, ER+/PR-/HER2-) (metastasis to the bones and lungs). Since then, she has tried 5 different drugs (below) and none of them have worked...
I have read that people go through periods where one drug may work for a bit but then it stops, so they try another one and it works for a bit and then stops... But it seems that for my mom none of the drugs have worked, is that common? She keeps changing them after only 2-3 months on each (every time she has a PET/CT, it always shows that the cancer has progressed). I'm curious if anyone has been in a similar situation and if you had any advice or things that have worked for you? is there always at least one drug that should work for a bit? I've done research and attended virtual conferences (eg Metastatic Breast Cancer Research Conference) and the drugs they have given her seem to be the latest in the research so not sure what else can be done. In the last appt, the Dr said she could keep trying other drugs but her body will get weaker and weaker (she has lost a lot of weight) so another option is to stop all treatments...
I'm curious to hear about other people's experiences about what they've done after all drugs seem to have not worked.. Did you start a clinical trial? Did you just stop the treatments? Did you try another drug that worked for you but is not listed below? Much appreciated!
These are all the drugs she has tried since her MBC diagnosis:
March 2020 - Abemaciclib (Verzenio) + Faslodex (Fluvestrant)
Oct 2020 - Kisqali (Ribocilib)
Jan 2021 - Abraxane (Paclitaxel) + Faslodex
March 2021 - Doxorubicin + Cyclophosphamide + Faslodex
May 2021 - Eribulin + Faslodex