Anyone else ER+ but PR-?
ER+, PR-, HER2+ is a very rare subtype, but I was hoping that with the size of this forum I might find others with this diagnosis. I've completed TCHP, surgery, and Kadcyla, and am now on ovarian suppression (Zoladex) and supposed to be taking aromatase inhibitors (Letrozole). Originally they were going to put me on Tamoxifen, but I did some research and saw that Tamoxifen resistance is common with PR- and my oncologist agreed and said I should do OS/AI instead. (I have to admit, I was hoping she would say we shouldn't bother with endocrine therapy at all. Like that would happen, lol.) I'm 5 months in and am miserable with insomnia, brain fog, fatigue. I'm pretty certain it's the artificial menopause, since it was like this during chemo induced menopause. I had a brief 3 months break from feeling this way midway through Kadcyla, when I got my period back and suddenly started sleeping through the night again. I'm desperate to feel better again, but afraid of having a recurrence. I feel like with my subtype and Kadcyla for early breast cancer being a new therapy, there's no way to know how much hormone therapy will or won't help me in the long run. My oncologist says "on an individual level, it doesn't make sense, but on a population level, it does." I don't know what to do!