Shall I do additional Anthracyclines after neoadjuvant TC?
Hello Everybody, I was diagnosed with ER+ PR+ HER2- grade 2 IDC+DCIS with a positive node via biopsy/image. I did neoadjuvant TCx4 followed by Umx. While the tumor and positive node both shrank a bit, there is still a lot of residue cancer left. My pathology also found LVI and ENE, and an additional node with ITC. I saw my MO, and she recommended starting exemestane. Toward the end of my appointment, I asked if my neoadjuvant chemo was adequate. She said there may be some additional benefit to do Adriamycin treatments (4 cycle). Especially given I am relatively young, I may want to do it to minimize metastasis risk. But since I did not have a super great response to TCx4, additional chemo may not be that helpful. I of course want all effective treatments, but on the other hand it seems that my MO only discussed it with me because I asked the question. I tried to search this site, but could not find much information. I would love to hear your inputs.