Confused about histopathology report
my mom had breast cancer diagnosis on 4/12/23 after which she underwent a unilateral mastectomy. At first she was reluctant to undergo mastectomy but with support from you all she finally did. Throughout this journey I could not have done without support from the posts here as it helped me learn so much the diagnosis and the treatments available. I dont think the Doctors had so much time to explain all this to me.
Again I am getting medical advice from 2-3 specialists but need your insights as you all have been through this.
I got 2 pathology reports done on the tumour in the right breast which was 3.5 cm.
First says it is a TRIPLE NEGATIVE low grade adenosquamous carcinoma which is a very rare cancer. The tumour grade NBR is 2+2+2. I showed it to the specialist who said take Xeloda and it would prevent recurrence for 2-3 years.
I was not convinced as it is TNBC then why would it not recur..
Second report says it is TNBC again. It does hightlight some more cellular stuff as below:
Within the mass is a large abnormal squamous island with squamous cells that are discohesive, with the observed cellular discohesion likely artifactual. This large squamous island merges with smaller irregular anastomosed tumour trabeculae extending into desmoplastic stroma, consistent with invasive carcinoma with squamous differentiation.The fibrosclerotic stroma that forms the mass harbours many scattered tubules of variable sizes containing luminal mucin as well as pink colloid-like material.Cystically dilated tubules with calcifications are present. Some of the tubules appear to be accompanied by myoepithelial cells while others seem to be devoid of obvious myoepithelial cells.
Lot of DCIS is seen. Histological type: Ductal with squamous differentiation.
My mom is refusing chemotherapy as says she is old and will die of chemotherapy. I read the posts here and do encourage her to go ahead with it but she says she would not abe able to handle the side effects.
Doctor says okay to no chemotherapy and says if we do not do anything the cancer would not return for 2-3 years.
However my research shows TNBC can come back anytime.
I asked Doctor about Natera and Guardant 360 to check if any targeted therapy can work but he said no.
Is the Doctor too conservative and just giving up on my mother.
Is it true that a 80 plus diabetic cannot survive chemotherapy and will have a poor quality of life after that.
Is it true that low grade adenosquamous carcinoma which is triple negative does not need any treatment.
I seek your advice as despite medical advice from 3-4 specialists noone is giving me a clear answer and casually rejecting chemotherapy.
I do not want her to get mets and die a painful death. I want her to fight this cancer but seems like the Doctors are not to keen either.
Any advice or insight is Godsent.
Thank you all.