Elacestrant/Orserdu
1QT.2024 My TM CA-15-3 went up. I am very nervous. I just started Elacestrant its my 2nd week and i am getting mixed messages here about that it causes spikes in tumormarkers activity for some patients and not so much for others. I was taken off my previous meds Kisqali+Letrozole on Jan 5th after PET scan that showed new progression in liver. On Jan 5 my CA-15 =67. Today ITS = 126! There's no way of knowing whether this activity happened when I was off meds from Jan 5 - Feb20 while sorting out NGS and deciding on the new treatment or just now on my 2nd week of taking Elacestrant.In addition I have ESR1 RNA FUSION nor the actual mutation. Please share your experience on this drug.. THANK YOU!
01/2016 - BC right breast ER+/PR-99%, Her2Neu - , CHECK-2 +
01/2016 - 01/2017 surgery, DDAC-T and radiation
12/2021 - BC left breast ILC ER-/PR-/HER2 equivocal, completed a bilat mastect
03/2022 - MBC mets to the spine, chest wall, and sternum (ER+/PR+/HER2 negative)
07/2022-09/2023: Ibrance + Faslodex
08/ 2022 Progressions/ bones. Tempus testing was negative for ESR1
10/2023-01/2024: Kisqali + Letrozole
12/2023 Progression internal mammary lymph node, sternum, and liver. NGS Caris testing was completed and revealed ESR1 RNA fusion, PD-L1-10
2/2024 - Elacestrant ( Orserdu) Was 2 months off meds
Comments
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Hi @natalki_poltavka - just seeing your post and wondering if there’s another thread on this topic because I don’t see any responses. I was told this week that I’ll be starting elacestrant after being off any treatment for almost a year. My MO was waiting for my lungs to heal after using Affinitor. How have you made out on Orserdu since it’s been over a year now? How are you doing? My markers have gone from 132 to 194.
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@sharware Here is the bigger thread on Elacestrant (Orserdu). We hope this helps!
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