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So I'm highly hormone positive, but failed ibrance after 5 years. Got a new triple negative. Did carbo/taxol. Mastectomy, then new hormone positive mets after 8 months of xeloda. Doctor wants to do enhertu because she is worried about hormone treatment resistance and possible triple negative cells still floating around. It's been 3 years since any hormone treatment. I'm really worried about enhertu side effects. I had no quality of life on carbo/taxol. Shouldn't we at least attempt hormone therapy? I was fine on letrozole/ibrance for 5 years. Minimal side effects. Plus my triple negative is her2 0. Seems chances are low that enhertu will work on it anyway. I have a second opinion scheduled but it's not for 3 weeks. Any advice?

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