Moving on from Ibrance to Orserdu

After 7.5 years on Ibrance & Letrozole I had slight progression. A blood biopsy was ordered and I remained on I/L. I had developed great pain in my shoulder and this was found to be cancer. Blood biopsy reported ERS1 & PIK3CA mutations. I completed 5 rounds of radiotherapy to the shoulder and 2 days later on 29th of March I started Orserdu. I had a great run on I/L however I suspect my bone mets had been around a lot longer than 7+ years. My BC was Dx in 2004.

Comments

  • chicagoan
    chicagoan Posts: 1,132

    Chico-Sorry to hear about this. I consider you my "Ibrance twin" since we started at the same time. I hope that Orserdu is very effective for you. Please keep us posted on how it is. It seems that your mutations may give you some other options as well. Hope that the radiation will get rid of the pain in your shoulder.

    I have scans next week-I do feel concerned since I have some mild low back pain but figure better to find out and change treatments if necessary. Best wishes.

  • chico
    chico Posts: 202

    Chicagoan thank for your support I did consider sending you a private message as we have been treatment twins. Wishing you luck with your scan and I hope you can remain on your current treatment. I will let you know how I get on with orserdu.

  • mc22
    mc22 Posts: 23

    Chico, I'm sorry to hear about this as well and wanted to wish you all the best on Orserdu. I hope it works very well for you!

    Chicagoan, hoping you get good news on your scans.

  • cure-ious
    cure-ious Posts: 2,989

    Chico & Chicagoan, You both seem to have a somewhat more gentle course overall, with at least some durable responses to early lines, and tho nothing lasts forever in this weird world, it gives a lot of hope that subsequent treatments may also respond quite well- good luck!

  • chico
    chico Posts: 202

    Into my 2nd month with Orserdu with no s/e’s which is fab but also not what we are used to with our meds. My shoulder following radiotherapy is still not back to full functionality but slowly getting less painful. Blood tests every 3 weeks and scans at 3 months so I will report back.

  • chicagoan
    chicagoan Posts: 1,132

    Chico, so glad you are not experiencing any side effects. Thank you for the update.

  • chico
    chico Posts: 202

    After 6 cycles my bone scan this week showed stable. Hope to get a good run on Orserdu (elacestrant).

  • chicagoan
    chicagoan Posts: 1,132

    That's great news Chico! Hope you get a good long run on Orserdu.

  • cure-ious
    cure-ious Posts: 2,989

    Awesome news, Chico, its kind of amazing endocrine therapy can still be working so many years out!!!

  • chico
    chico Posts: 202

    I am pleased to report that my scans show continued stable disease whilst still on Orserdu. This is such an easy medication with the added bonus of normal bloods. Long may this run last.

  • chicagoan
    chicagoan Posts: 1,132

    Chico-So good to hear your news! Long may this run last indeed!

  • sf-cakes
    sf-cakes Posts: 635

    So good to hear your latest scans were stable, Chico! Thank you for the update, keep on keeping on 😊

  • aprilgirl1
    aprilgirl1 Posts: 812

    Chico, this is great news ! Thanks for the update:)

  • Hello! I have been on letrozole/IBrance since 2017 and also had a blood test showing new ESR1 and Pik3A mutations. But instead of Orserdu the oncologist has me switching to Faslodex/Verzenio. I wonder why not Orserdu….

  • chico
    chico Posts: 202

    Thank you Chicagoan, Sf cakes and April Girl. Hope you all are doing well.

    Hi polemonium it seems that different Oncs chose different methods however I had progression so Ibrance and Letrozole had failed me therefore V & F would not have worked for me. I actually requested Orserdu and as a monotherapy I’m glad I did as it is easy. I also have a lot of PIK mutations and it is good to see so many new things being approved that will be available to us. Good luck and please let us know how you get on.