Discontinuing Anastrozole
Hi All - In 2024 I had diagnosis of Stage 2A ductal carcinoma ER/HR+ HER2 -. BRCA 2 positive. 3cm tumor no metastasis to lymph nodes. I took an aggressive stance on surgeries, opting for a double mastectomy with nipple removal (January 2024) and then removed my ovaries and fallopian tubes in September 2024.
I started AI with Anastrazole in October 2024. Unfortunately I've had every symptom associated with taking the medication: hot flashes, terrible mood swings, insomnia, brain fog, dizziness, and joint pain. I've been prescribed various medications to address those side effects but they tend to make me feel even more out of sorts and not myself. I am also mildly worries about the progression of osteoporosis long term with this drug as my mother also ended up with it after doing AI treatment.
I am meeting with my oncologist to discuss this soon but curious if anyone here has had to make a decision about whether or not to take Anastrazole because of how much it interferes with quality of life. What factors did you consider and how did you approach those conversations with your clinical team?
Comments
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Ali-Mac, I’m so sorry to hear that you’re experiencing side effects from this medication—it’s such a challenging situation. From my experience with Letrozole, which was incredibly hard on my body, my oncologist recommended Aromasin, and I found it much easier to tolerate.
Additionally, he suggested Zometa infusions every six months for three years. These not only help reduce the risk of recurrence slightly but also provide significant protection against osteoporosis. It might be worth discussing this option with your doctor.
I completely understand the fear of not taking any AI after a Stage 2 diagnosis. I hope you’re able to find an approach that works better for you soon. Sending you strength and best wishes.
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Hi @ali_mac,
We're so sorry to hear of the difficulties you're having! As lillyishere mentions, many folks who have side effects with one medication have a completely different (or at least less-difficult) experience with another aromatase inhibitor.
There are three aromatase inhibitors doctors use to treat breast cancer:
- Arimidex (chemical name: anastrozole)
- Aromasin (chemical name: exemestane)
- Femara (chemical name: letrozole)
So maybe bring this topic up with your doctor to see if another option might be available for you to try.
We hope this is helpful to you and that you find some relief soon!
—The Mods
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