Triple-Negative Breast Cancer Treatment: Where Are We?
Triple-Negative Breast Cancer Treatment: Where Are We?
Dr. Lisa Carey explains the latest research on TNBC treatments.
Mar 7, 2025
About 10% to 15% of breast cancers are triple-negative. This means they don’t have receptors for the hormones estrogen or progesterone, and don’t have too many HER2 proteins. So, hormonal therapy medicines and medicines that target the HER2 protein aren’t effective against triple-negative breast cancer.
Chemotherapy and immunotherapy are commonly used to treat triple-negative disease. But scientists are working diligently to develop new treatments that are more precise and targeted.
Triple-negative breast cancer expert Dr. Lisa Carey explains the latest research.
Listen to the episode to hear Dr. Carey discuss:
- the two main areas of research on triple-negative breast cancer
- what antibody-drug conjugates are and their potential for treating triple-negative disease
- the benefits of combining antibody-drug conjugates with immunotherapy
- the features of triple-negative breast cancer that make researchers think a vaccine for it is possible
Comments
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Hello all,
I have triple negative BC. I had a lumpectomy. Have started chemotherapy. The second session will be tomorrow. My Dr said I may have four or more sessions and also a mastectomy.
Will the cancer go away after the chemo? Do I still need to go for a mastectomy. I just want an honest answer . I am open to suggestions that will help. I really do not care much about keeping my breast cos I’m post menopausal already.
Thank for this opportunity.0 -
Hello again, @tabsie!
We’re really sorry you’re going through this, and we understand your fears. Right now, everything can feel very confusing and scary.
Nobody here can tell you for sure whether cancer will come back or what your exact outcome will be, since every case is different. Your oncology team is really the best place to guide you on whether a mastectomy is recommended after chemo and what your treatment plan should look like.
You might want to join this discussion for peer support and to connect with others with triple negative breast cancer, see here: Calling all TNs. It could be helpful to hear from others who have been in a similar situation.
We’re really glad you found us, and we’re here for you.
The Mods
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I have TNBC and just started chemo this last Monday (11 May). I did not see my treatment plan listed when I did my profile. It is called NeoPACT and is a variation of Keynote 522 with
- CARBOplatin (PARAPLATIN)
- DOCEtaxel
- pembrolizumab
Curious if anyone else is using this protocol and how it is going.
thanks!
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