Single Hormone Receptor Positive -> ER+/PR-/HER2-
Comments
-
@walsr014 I’ve not heard a verbatim statement that most PR- are in the clear after 5 years. After my surgery, chemo, and radiation, my probability of recurrence in 9 years is 13% plus or minus about 7% on either side. (Confidence interval). I do know that after 5 years we are considered to be in remission, so that sounds great to me!
When I was in treatment I read everything I could find on ER+ PR- HER2- which falls in the Luminal B category. Many of the journal articles do note that it has a higher risk of recurrence than more common Luminal A.
Now at almost 3 years to my anniversary (surgery date is what oncologists use) I’m grateful to be feeling good with everything clear so far. I’ve been getting Signatera (looks for circulating tumor cells that match my sample) screenings all along, and knowing they have all been negative is helpful to me. I also spend very little time thinking about BC compared to year one. I do still have all my saved articles though…
An article in BJS by M.G. Daley et al called “The impact of progesterone receptor negativity on oncological outcomes in oestrogen-receptor-positive breast cancer” had some interesting graphs. Screenshot below. Markings are mine. (Search: BJS Open, 2021, zrab040 DOI: 10.1093/bjsopen/zrab040 for the full article.
0 -
Shelle1, all is not grim! I'm coming on 8 yrs BC free. It helped me to become proactive in my health and well-informed. A bunch of us PR-negs have been through this and if you have questions or need moral support, please ask.
1 -
8 years is Amazing. As someone new to this, who has been spinning and quite depressed, I often look at this thread for support. Thanks for sharing your story.
1 -
I have er 90 and pr 15. Do I fall in this subtype? I’m pretty scared.
0 -
I was really scared also, but almost 4 years later am more grateful for the high ER and less worried about the low PR. Having something (ER) to target is really a blessing. There are so many of us in this category doing well. I can definitely celebrate that! I’m not certain you would be PR-, but regardless, I expect you will also do very well!
0 -
Yunakagome, in my opinion, you are not PR-. Has the Oncotype test been performed on your tumor tissue? That number will give a better idea of its ER and PR functionality.
0 -
Hello Yunakagome; If I recall correctly, I was 100% ER+, and PR =0%, and HER-2 negative. I was diagnosed in 2019 (58 years old), had a lumpectomy, chemo. & radiation. My oncologist strongly recommended chemo because I had a high oncotype score. I also wonder if you are single hormone receptor positive. Ask your BC surgeon and Oncologist to clarify, help you understand your pathology, and treatment plan. Keep us posted!
0 -
hi. I had an oncotype of 21. The oncotype papers said er was around 10.2 and I think pr was 7.2. I’m confused about those because someone I know is 90% pr but her pr on oncotype was 7.8 which doesn’t look to be much higher than mine. I honestly don’t know what oncotype is testing for with er and pr exactly
All the studies I’ve read said pr low was <10% and pr -0% and there was not a heck of a lot of difference in outcomes for pr- vs pr 10-%. A bunch of papers also said pr>20 had much better outcomes which are more lum a like. I’m sorta in the middle I think.0 -
@sarahsmilesatme what was your oncotype and mass size if you don’t mind sharing.
0 -
Yunakagome; sorry; I actually can’t recall my mass size. I had 3 very small tumors and thankfully, no lymph node involvement. My BC was caught very early during my annual mammogram. It was the oncotype that drove the chemo decision; and my score was quite a bit higher than 21. As my oncologist told me early in my diagnosis, I can’t control the pathology, but I can control the treatment.
0
