Has anyone with Her2+++ achieved pCR before surgery using only paclitaxel and Phesgo?
Hello from Tokyo.
I am currently undergoing treatment for Her2+++(ER+1%)
The preoperative regimen is 12 doses of weekly paclitaxel and 4 doses of Phesgo every 3 weeks, and if the tumor does not disappear, EC will be added.
I searched on X and found that there was one woman in Osaka,Japan who underwent a clinical trial of paclitaxel and Phesgo before surgery and she achieved remission after pCR without EC in 2023. She had 14 sessions of Phesgo after surgery.
Tomorrow I am scheduled for my 10/12 Paclitaxel and my final Phesgo(4/4) before surgery.
Hope all of you have warm and peaceful day!
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Hi @tofudaisuki, and welcome to Breastcancer.org. We’re glad you found us. Wishing you all the best with treatment number 10 tomorrow and your final Phesgo. Please keep us posted on how you’re doing and let us know if we can help in any way.
The Mods
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Hello.
Preoperative treatment is complete. The side effects from weekly paclitaxel and Fesgo were milder than expected and caused absolutely no disruption to daily life. The ultrasound showed the tumor has almost disappeared, though a small amount may remain. I was told it's close to pCR. If any residual tumor is found, Kadcyla will be added.
The total mastectomy surgery is scheduled for the end of January 2026. I had a pre-op mammogram and MRI, so I'll post again if anything happens. Mammograms aren't done in US anymore, are they? They're a bit painful.😅 I guess I have to wait and see the pathology results.
I sincerely hope everyone has a peaceful holiday season.😊
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@tofudaisuki mammograms are still very much standard of care in the US. Good luck with your treatment!
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Oh no, mammograms do exist! I wish there were a better screening method to replace them. Thank you for the information. I hope you have a nice holiday.
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Hi @tofudaisuki:
I just started the same exact treatment you had. I'd love to know how your surgery came up and if you're still on post-op medication.
I hope you're doing great.
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Hello p_____a
I haven’t posted an update for a while because there was a break in my treatment. My pathology result was pCR.
Paclitaxel finished in December. My doctor thought there might still be some remnants on the ultrasound, but the MRI showed that the tumor had essentially disappeared, so I underwent a lumpectomy at the end of January.
The surgery itself took about two hours. Recovery was surprisingly smooth — I didn’t even need pain medication afterward and was discharged the next day.
I started radiation therapy in March and received 16 sessions, every day except weekends. Since the tumor was on my left side, my doctors wanted to be careful about my heart, so there was a one-month break after radiation before restarting treatment.
I resumed Phesgo on May 8th, and the plan is to continue for about 14 treatments through the end of this year.
The regimen using only paclitaxel and Phesgo was relatively gentle on my body. Aside from losing my hair, I was able to live pretty normally throughout treatment. I did have some mild neuropathy, but it has improved now. I was told that walking is one of the best ways to help with neuropathy, so I made a point of walking at least 7,000 steps every day.
I know there will be many difficult moments ahead, but I’m sincerely cheering for you from afar. I truly hope your treatment works wonderfully for you too.
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One thing I forgot to mention: the sentinel lymph node biopsy showed no lymph node involvement.
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