ER+PR-HER-
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frankp, I see from your BCO profile that you have a professional interest in diagnostic testing.
Could you please explain how serum HER2 monitoring would be of benefit in someone whose tumor was HER2-negative by IHC, FISH, and, if available, RT-PCR? In a quick literature scan, I was not been able to find a documented indication for use of serum HER2 testing under those circumstances - not one that would stand muster with ASCO, NCCN, or the FDA, anyway. Are there data to support that use?
I could try to read between the lines, but I'm interested in your explanation.
otter
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Just got my past lumpectomy pathology results and I have 3 tumors with 3 different types and different pathology. RO said need to see genetics test results because he suspects genetic type and possible more surgery. I don't want more surgery now. The waiting is killing me. Literally, crushing my spirit everyday. Anyway, the big shock was the core biopsy showed strong ER/PR+ (more than 90%) each and now this pathology shows ER 98+ and PR-. The Ki67 dropped a lot too, but I heard that was common. I am 40 so not thrilled about ovarian suppression either. Should I ask for them to rerun the test? Did anyone have additional surgery based on the hormone receptors?
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Dottybird, Sorry you had to join this forum, but this is an additional place to seek information. Please see the link below (if I copy & pasted correctly)
https://community.breastcancer.org/forum/96/topics/872099?page=1#idx_28
The thread is called Newly diagnosed ER+ PR- HER2- if you can't pull it up. This thread that may answer some of your questions. It is more recent than the thread you posted on. I hope this helps. Wishing you all the best.
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Yes, I am ER+ PR-. I didn't see any of your messages to me until now. I don't know when you sent them. From a breast cancer point of you, I am "cured." Diagnosed 2010, had bilateral mastectomy, chemo and 9 years of Arimidex. Breast cancer free. However, I developed lung cancer in 2013. Still being treated for that, but NED (no evidence of disease). How are you doing? What treatments have to had? Stay in touch!
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Hi @yunakagome , and welcome to Breastcancer.org. We can hear how anxious and overwhelmed you’re feeling right now, and it makes sense to want to reach out to others who’ve walked a similar path.
Just a quick heads up that this thread is quite old, and many of the members you’re tagging may no longer be active here, which is why you may not hear back. Posting repeatedly in older threads can also make it harder for current members to see and respond to you.
You may get more support by starting your own new thread in the appropriate forum and sharing what you’re dealing with now. We also encourage you to fill out your profile with your diagnosis details and treatments, since members often look there to understand your situation before replying.
You’re not alone here, and we’re glad you reached out. We’re here to help you find the support you need.
Best,
The Mods
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ok thank you.
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