Bone Mets Thread

My MO called and ordered letrozol to start immediately and blood testing and an EKG before starting the Kisqali. She has also ordered radiation for my spot on my spine because it is putting pressure on my cord and she doesn’t want it to get any worse. Also I received my Guardant ctDNA report and it indicates .8% PIK3CA. Do any of you know about this marker and have thoughts? My MO said it meant there might be some differences in my treatment but she is going to start with the letrozol and Kisqali to see how it goes for 3 months. Then more scans to see how it is working.

I am getting nervous. I am also really sick of all of the cancer I have had to deal with in the last 11 years. It seems way too much!

@wren44 Did the PIK3CA change your treatment? Just curious. It sounds like the SEs from the PIK3 treatment protocol include spiking blood sugar. I am already pre-diabetic so it is a bit of an issue. I also live alone so not sure how this will work.