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Topic: RSClin oncotype scores

Forum: Stage I Breast Cancer — Meet other members with a Stage I breast cancer diagnosis to share information and support.

Posted on: Jan 22, 2021 10:20PM

everetta wrote:

I have heard there is a new way of looking at the oncotype score that is a tool that takes into account your clinical features and gives an even more accurate predictive and diagnostic score. Does anyone know how you can find your RCSlin? I have a one centimeter ILC, node negative, grade 2 tumor and was 68 at diagnosis. I had a 31 oncotype but wonder what my RCSlin be?

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    Mar 12, 2021 01:49PM speedlady wrote:

    We are in a similar situation. I am 73, 1.1 cm, node negative, grade 1, oncotype 27. My oncologist said she couldn't recommend chemo either yes or no, it is up to me. I am saying no. I don't have that much life left and an additional 3% is not significant enough to ruin 2 years of my life.

    My oncologist showed me the RCSlin program during our consult. I didn't find it to be very useful.

    Dx 1/25/2021, ILC, Left, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR-, HER2- (IHC) Surgery 2/16/2021 Hormonal Therapy 3/18/2021 Radiation Therapy
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    Mar 12, 2021 02:16PM moth wrote:

    OP, your oncologist should how you the calculation. It's a calculator on a site that requires instititutional access.

    Initial dx at 50. Seriously???? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: nevertellmetheodds2017.tumblr.... Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, ER+/PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External Hormonal Therapy 12/15/2020 Femara (letrozole) Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone, Grade 3 Radiation Therapy 3/3/2021 External: Bone
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    Mar 12, 2021 02:24PM Beesie wrote:

    speedlady, with the Oncotype 27, what did the report say your recurrence risk would be if you did endocrine therapy alone (i.e. no chemo). And after running the RSClin model, did this recurrence risk figure come down? I would think it would, given your age, your relatively small tumor and with the cancer being grade 1. All 3 factors are more favorable than the averages used to determine the Oncotype recurrence risk estimates.


    Dx 9/15/2005 Right, 7cm+, DCIS-Mi, Stage IA, Gr 3, 0/3 nodes, ER+/PR- ** Dx 01/16/2019 Left, 8mm, IDC, Stage IA, Gr 2, 0/3 nodes, ER+/PR-, HER2- (FISH) ** Surgery 11/30/2005 MX Right, 03/06/2019 MX Left ** Hormonal Therapy 05/2019 Letrozole
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    Apr 3, 2021 02:05PM speedlady wrote:

    Beesie, my recurrence risk with AI and radiation is 6%. Add chemo and it drops to 3%. To me it wasn't worth the extra 3% to go through chemo, especially at my age. If I were 20 years younger I'd do it. I can live with 94% chance of no recurrence. Thanks!

    Dx 1/25/2021, ILC, Left, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR-, HER2- (IHC) Surgery 2/16/2021 Hormonal Therapy 3/18/2021 Radiation Therapy
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    Apr 3, 2021 06:59PM thecargirl wrote:

    Bessie, do you think there is a big difference between RSCP and the RSClin model results . You enter the same information, it would be interesting to see the comparison. The RSCP really dropped my recurrence risk.

    Thanks,

    Susan

    Lt Lumpectomy 9/16,

    7mm pure mucinous, Stage 1, Grade 1, ER 95% PR 95%, HER-

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    Apr 3, 2021 07:40PM Beesie wrote:

    Susan, to my understanding RSClin would be considered an updated and refined version of the RSPC model. I don't know for sure but I suspect the results would be pretty similar.

    RSClin was "derived from a larger and more contemporaneously treated cohort than that used for the development of RSPC" and adds an "estimation of incremental absolute chemotherapy benefit not previously provided by RSPC".

    Development and Validation of a Tool Integratingthe 21-Gene Recurrence Score andClinical-Pathological Features to Individualize Prognosis and Prediction of Chemotherapy Benefit in Early Breast Cancer



    Dx 9/15/2005 Right, 7cm+, DCIS-Mi, Stage IA, Gr 3, 0/3 nodes, ER+/PR- ** Dx 01/16/2019 Left, 8mm, IDC, Stage IA, Gr 2, 0/3 nodes, ER+/PR-, HER2- (FISH) ** Surgery 11/30/2005 MX Right, 03/06/2019 MX Left ** Hormonal Therapy 05/2019 Letrozole
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    Apr 3, 2021 08:59PM thecargirl wrote:

    Thank-you Bessie!

    Susan

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