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Topic: Single Hormone Receptor Positive -> ER+/PR-/HER2-

Forum: Less Common Types of Breast Cancer — Meet others with less common forms of breast cancer, such as Medullary carcinoma, Inflammatory breast cancers, Mucinous carcinoma (colloid carcinoma), Paget's disease, Papillary carcinoma, Phyllodes tumor, Tubular carcinomas, Metaplastic tumors, Adenoid cystic carcinomas and Angiosarcoma.

Posted on: Sep 17, 2017 12:28PM

seemaryrock wrote:

Anyone else in this same boat? Would love input or sharing your experience. Feeling a little alone in this boat!

Married mother of 7-year-old son and 2-year-old daughter. Diagnosed at age 40. Mother had it 4 years ago and sister (46) was diagnosed 2 weeks after I was. Dx 7/19/2017, DCIS/IDC, Left, 1cm, Stage IIA, Grade 2, 2/15 nodes, ER+/PR+, HER2- Surgery 8/30/2017 Chemotherapy 10/16/2017 AC Radiation Therapy Whole-breast: Lymph nodes Surgery Lymph node removal: Left, Sentinel, Underarm/Axillary; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement
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Sep 17, 2017 02:42PM - edited Sep 17, 2017 02:42PM by balance

As you can see from my stats, I'm paddling right beside you. I'm 5 years out...so far, so good.

Dx 5/3/2012, IDC, 1cm, Stage IIA, Grade 3, 1/15 nodes, ER+/PR-, HER2- Surgery 5/7/2012 Lumpectomy: Right; Lymph node removal: Right, Underarm/Axillary Chemotherapy 6/12/2012 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Hormonal Therapy 10/6/2012 Arimidex (anastrozole) Radiation Therapy 10/8/2012 Breast, Lymph nodes
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Sep 17, 2017 05:45PM Kiks1 wrote:

I am er 80% and pr 1%, her negative. It had always weighed heavy on my mind reading about how this can mean that the tumor is more aggressive. I had my ovaries out and started on aromasin since I have read that als can be more effective for pr negative patients. To be honest, my new normal is a lot more worrisome than my old normal. I jump at every pain and ache. I hang on to hope from long term survivors who have the same pathology like balance above.

Dx 11/30/2015, IDC, Right, 2cm, Stage IIA, Grade 2, 0/2 nodes, ER+/PR+, HER2- Surgery 12/16/2015 Lymph node removal: Sentinel; Mastectomy: Right; Prophylactic mastectomy: Left Chemotherapy 2/5/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 5/5/2016 Aromasin (exemestane)
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Sep 17, 2017 06:25PM balance wrote:

Kiks - I was only 75% ER.

Dx 5/3/2012, IDC, 1cm, Stage IIA, Grade 3, 1/15 nodes, ER+/PR-, HER2- Surgery 5/7/2012 Lumpectomy: Right; Lymph node removal: Right, Underarm/Axillary Chemotherapy 6/12/2012 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Hormonal Therapy 10/6/2012 Arimidex (anastrozole) Radiation Therapy 10/8/2012 Breast, Lymph nodes
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Sep 17, 2017 07:45PM bravepoint wrote:

balance,

Your profile is pretty similar to mine but I'm 3% ER +, PR- and HER-. Just started on Exemestane (Aromasin) today after trying Letrozole. It's great to see you are 5 years out!

Gail Radiation Therapy 4/17/2016 Whole-breast: Breast, Lymph nodes, Chest wall Dx 8/8/2016, IDC, Right, 1cm, Stage IIA, Grade 3, 1/5 nodes, ER+/PR-, HER2- Surgery 8/29/2016 Chemotherapy 10/6/2016 AC + T (Taxol)
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Sep 24, 2017 04:58PM balance wrote:

Bump.

Dx 5/3/2012, IDC, 1cm, Stage IIA, Grade 3, 1/15 nodes, ER+/PR-, HER2- Surgery 5/7/2012 Lumpectomy: Right; Lymph node removal: Right, Underarm/Axillary Chemotherapy 6/12/2012 Adriamycin (doxorubicin), Cytoxan (cyclophosphamide), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Hormonal Therapy 10/6/2012 Arimidex (anastrozole) Radiation Therapy 10/8/2012 Breast, Lymph nodes
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Sep 25, 2017 06:59AM Desirr77 wrote:

I was ER 10% + and PR-. My tumour was retested on DNA basis and then it came back triple negative.

When ER is slightly positive and PR is negative I would opt for a retest, because doing hormonal therapy for nothing is not that funny.

Dx 2/4/2016, IDC: Medullary, Right, <1cm, Stage IA, Grade 3, 0/1 nodes, ER-/PR-, HER2- Surgery 2/9/2016 Lumpectomy: Right; Lymph node removal: Right, Sentinel Chemotherapy 3/1/2016 Cytoxan (cyclophosphamide), Ellence (epirubicin), Taxol (paclitaxel) Surgery 9/28/2016 Prophylactic mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Sep 25, 2017 07:19AM Mom_of_twins wrote:

I am! I worry about this, too. I was 99% ER+ and ranged from 2-10% PR+ (two different labs did pathology). I did chemo first, and afterwards it's was totally PR-. It's very concerning, but I'm hoping that the AI is still effective.

Did any of you above have the oncotype test? I always wondered what mine would've been, but it wasn't tested because I did chemo first

Dx 1/6/2016, DCIS/IDC, Left, 2cm, Stage IIB, Grade 2, 2/5 nodes, ER+/PR+, HER2- Chemotherapy 2/4/2016 AC + T (Taxol) Surgery 6/14/2016 Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Radiation Therapy 7/18/2016 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 9/29/2016 Arimidex (anastrozole), Zoladex (goserelin)
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Sep 25, 2017 08:34AM bravepoint wrote:

Desirr77 - How long after the first test did you repeat it? I was never offered that option but wish I had asked.


Mom of twins - I didn't have an oncotype test. Not sure if they even do them in Canada. I think if you have positive lymph nodes then they don't offer it.

Gail Radiation Therapy 4/17/2016 Whole-breast: Breast, Lymph nodes, Chest wall Dx 8/8/2016, IDC, Right, 1cm, Stage IIA, Grade 3, 1/5 nodes, ER+/PR-, HER2- Surgery 8/29/2016 Chemotherapy 10/6/2016 AC + T (Taxol)
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Sep 25, 2017 09:39AM ruthbru wrote:

I was 'mildly positive' (11-25%). I did chemo (it was a big, fast growing tumor), radiation (since I had a lumpectomy), and 5 years of an anti-hormonal (which I was VERY glad was an option; but being only mildly estrogen positive, my doctors and I didn't have any qualms about stopping after the 5 year mark). Since I am now 10 years out, I would definitely say I made the correct treatment choices for me.

"Invisible threads are the strongest ties." Friedrich Nietzsche Dx 2/2007, Stage IIA, Grade 3, 0/11 nodes, ER+/PR-, HER2-
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Sep 25, 2017 02:09PM kcat2013 wrote:

I'm here, except I was Her2+. I'm 4 years out and still kicking :) But I do ponder from time to time how the negative Pr affected/will affect things.


34 at diagnosis Dx 8/2013, IDC, <1cm, Stage IA, Grade 2, 0/4 nodes, ER+/PR-, HER2+ Surgery 9/4/2013 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 10/25/2013 AC + T (Taxol) Targeted Therapy 2/7/2014 Herceptin (trastuzumab) Surgery 6/20/2014 Reconstruction (left); Reconstruction (right)
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Sep 25, 2017 03:18PM - edited Sep 25, 2017 03:20PM by Desirr77

Dear bravepoint,

I repeated the test six month after my initial diagnosis. I am from Germany and my obgyn wanted to know whether tamoxifen was useful for me. I am also palb2 positie which often goes along with triple negative tumours.


Dx 2/4/2016, IDC: Medullary, Right, <1cm, Stage IA, Grade 3, 0/1 nodes, ER-/PR-, HER2- Surgery 2/9/2016 Lumpectomy: Right; Lymph node removal: Right, Sentinel Chemotherapy 3/1/2016 Cytoxan (cyclophosphamide), Ellence (epirubicin), Taxol (paclitaxel) Surgery 9/28/2016 Prophylactic mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Oct 4, 2017 04:17PM jenn70 wrote:

I am PR negative, ER positive and HER negative. I did Onco test, score was 26. Did not have chemo since MD Anderson said that the onco test is not a good test for tumors as small as mine (5mm).

Another oncologist had done the test before I went to MD Anderson.

Still scared about the PR negative and wondering if I should have had chemo. No nodes involved, Stage 1B. I am on Arimidex.

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Oct 5, 2017 04:52AM Meow13 wrote:

I was less than 1% pr, so pr- and 95% er +. I did 4 years AI drugs no chemo even though my oncodx was 34. I didn't have any positive nodes but 2 tumors each 1 cm, one idc and one ilc.

6 years NED so far.

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Oct 11, 2017 07:30AM KNardo88 wrote:

Hi! I am 20% ER+, PR-, HER2-. I was dx'd April of last year when I was 27. I had a double mastectomy and 4 rounds of AC chemo. I was node negative. I now am on Lupron and Femara. I, too, felt very alone with the single-hormone diagnosis and was very afraid when reading about the aggressive nature of these types of tumors but as you will see, no two tumors are alike and that is why treatments are being tailored to each patient these days. I am still only a year out of chemo but it gets easier every day. I hope you are doing well! Keep me posted <3

Kelly - Dx at age 27 - Luminal B - BRCA1+ ACx4 and OS & AI Dx 4/25/2016, IDC, Right, <1cm, Stage IA, Grade 3, 0/7 nodes, ER+/PR-, HER2- Surgery 5/20/2016 Lymph node removal: Sentinel; Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 6/22/2016 AC Hormonal Therapy 10/24/2016 Femara (letrozole) Surgery 10/31/2016 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Nov 29, 2017 01:43PM Maggieanne84 wrote:

I am 90% ER+ PR-(0%) Her2-. Are these types of tumors resistant to any treatment does anyone know?

Dx 7/25/2017, IDC, Right, 4cm, Stage IIB, Grade 2, 3/12 nodes, ER+/PR-, HER2- (IHC) Surgery 9/25/2017 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 11/14/2017 AC + T (Taxol)
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Nov 29, 2017 02:35PM JuniperCat wrote:

Maggieanne, that’s an interesting question... I’m hoping someone will provide information.

Dx 2015 stage 1A IDC 1.5cm ER+ PR- HER2-
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Nov 29, 2017 03:42PM Hopeful82014 wrote:

"I didn't have an oncotype test. Not sure if they even do them in Canada. I think if you have positive lymph nodes then they don't offer it."

Bravepoint - yes, the Oncotype DX is done in Canada, although I think each province has its own criteria for use. Oncotype DX can be and is used for node positive patients in the US and most countries. I can't speak for its use in Canada.

Dx IDC
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Nov 29, 2017 04:07PM mudd wrote:

I'm also ER+, PR- and HER2- and all my doctors said they weren't concerned with the PR value but the more I read about it, the more nervous I get. Waiting for my Oncotype DX results. Does the PR- affect that?

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Nov 29, 2017 04:34PM Blueshine wrote:

I have the same hormone receptors like you - er+,pr-,/her2 -

When they test my genes , it show that I have very rear gean mutation, only 100 people in the world have

I hope it help

Dx 9/2011, IDC, Right, 2cm, Stage IIB, Grade 2, 1/18 nodes, ER+/PR-, HER2- Dx 10/2017, IDC, Stage IV, metastasized to bone, Grade 2, ER+/PR-, HER2- Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Arimidex (anastrozole) Surgery Lymph node removal: Sentinel, Underarm/Axillary; Mastectomy: Right
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Nov 30, 2017 12:29AM Meow13 wrote:

I think my oncodx score was high due to my absence of pr, less than 1%. They wanted to do chemo but I chose AI drugs which seem to effective in our case, I was 95% er positive.

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Nov 30, 2017 08:19AM Maggieanne84 wrote:

I am pre-menopausal so they did not offer me anything for treatment other than chemo and radiation. I am only 33. Just wondering about tumor resistance because the information on these types of tumors is small. And I want to be around for my 6 kiddos as long as possible.

Dx 7/25/2017, IDC, Right, 4cm, Stage IIB, Grade 2, 3/12 nodes, ER+/PR-, HER2- (IHC) Surgery 9/25/2017 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Chemotherapy 11/14/2017 AC + T (Taxol)
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Nov 30, 2017 09:34AM - edited Nov 30, 2017 09:35AM by MameMe

Just saw this topic, I have wondered about this myself. My second episode of bc was 10 years after the first, and was er+, pr-, her2-. Opposite side, slightly higher grade. I did not do tamoxifen for more than 6 weeks after the first episode, due to side effects. I would try to manage that and do the five years if I had a do-over. I took the oncotype in 2012, and it came outlow risk, but since I had not done an ai, it was probably not valid. I watch closely when I see others with er+, pr-. I just wonder if its more significant than is generally said. I'd like to hear as much as possible from others with pr-.

Widespread, low volume mets to eye, lungs, chest wall and bones, dx 4/14/14. "There's gotta be a pony in this s--t somewhere..." Dx 2/2003, IDC, Right, 2cm, Stage IIA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Dx 12/2012, IDC, Left, 1cm, Stage IA, Grade 2, 0/2 nodes, ER+/PR-, HER2- Dx 4/4/2014, IDC, Left, 2cm, Stage IV, metastasized to bone/lungs/other, Grade 2, 0/1 nodes, ER+/PR-, HER2- (IHC) Chemotherapy 4/30/2017 Doxil (doxorubicin) Chemotherapy 2/28/2018 Halaven (eribulin) Chemotherapy Xeloda (capecitabine) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib) Chemotherapy Gemzar (gemcitabine) Targeted Therapy Afinitor (everolimus) Hormonal Therapy Aromasin (exemestane) Chemotherapy Taxol (paclitaxel)
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Nov 30, 2017 11:14AM ruthbru wrote:

I did chemo, rads & 5 years of Arimidex (as recommended by my doctor for my stage/grade etc.) I wanted to cover all the bases I could. So far, so good.......

"Invisible threads are the strongest ties." Friedrich Nietzsche Dx 2/2007, Stage IIA, Grade 3, 0/11 nodes, ER+/PR-, HER2-
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Dec 5, 2017 08:03PM DagnyT wrote:

Hi all,

I am going to see my bs for the first time tomorrow after getting my biopsy results on Friday. So I have been pouring over my report getting all my questions ready ....I am 100% ER+, 10%PR+ and HER2-. I didn't even know this was something to ask about....so glad I found this thread. I will inquire specifically about this and report back to you guys with anything I learn. I'm going to Dana Farber, so I hope I will be in good hands....although I realize that it is probably the oncologist more than the surgeon who will be able to answer this kind of question.


dx-12/1/17 DCIS R breast w/microinvasion IDC; ER+/PR borderline+; HER2-
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Dec 5, 2017 09:34PM Aaussiegal wrote:

I’m new here. Can I ask why is everyone worried about being PR negative? I’m mildly ER positive PR and HER Negative.

Dx 3/28/2017, IDC, Right, 3cm, Stage IIB, Grade 3, 1/11 nodes, ER+/PR-, HER2- Chemotherapy 3/29/2017 TAC Surgery Lymph node removal: Sentinel, Underarm/Axillary Surgery Mastectomy: Left, Right Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole-breast: Lymph nodes, Chest wall
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Dec 5, 2017 09:34PM StubbornDog wrote:

Hi, I am new here (been lurking for a month or so), with surgery this Friday. I am 10% ER+, PR- HER2- grade 3 IDC/DCIS. Glad to see some positive stories! I have already been told I will very likely (95% chance) have chemo since this is almost a triple negative, but they won't know for sure until they do the pathology on the tumor and get the lymph node results.

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Dec 6, 2017 07:48AM Moderators wrote:

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Dec 6, 2017 08:40AM ruthbru wrote:

Aasussie, I think being PR negative bothers people because it more rare. I don't think doctors really know the impact it may, or may not, have on how effective anti-hormonals are etc. My feeling is that since I can't do anything about it, I don't worry about it.

"Invisible threads are the strongest ties." Friedrich Nietzsche Dx 2/2007, Stage IIA, Grade 3, 0/11 nodes, ER+/PR-, HER2-
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Dec 6, 2017 06:27PM wintersocks wrote:

Is er+ 'a less common kind of cancer?' I am minus everything else and 100% oestrogen positive. I have never heard that this is a less common type. Does anyone understand the implication of being pr -

Dx 2/20/2012, IDC, 6cm+, Stage IIIA, Grade 2, 4/11 nodes, ER+/PR-, HER2- Chemotherapy 3/23/2012 Doxil (doxorubicin), Taxotere (docetaxel) Surgery 8/29/2012 Lymph node removal: Right, Underarm/Axillary; Mastectomy: Right Hormonal Therapy 9/10/2012 Femara (letrozole) Radiation Therapy 9/16/2012 Breast, Lymph nodes
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Dec 6, 2017 08:12PM bravepoint wrote:

Stubborndog - You have a similar diagnosis to me but I am only 3% ER +. Good luck with your surgery!

Gail Radiation Therapy 4/17/2016 Whole-breast: Breast, Lymph nodes, Chest wall Dx 8/8/2016, IDC, Right, 1cm, Stage IIA, Grade 3, 1/5 nodes, ER+/PR-, HER2- Surgery 8/29/2016 Chemotherapy 10/6/2016 AC + T (Taxol)

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