Share your research articles, interpretations and experiences here. Let us know how these studies affect you and your decisions.
Posted on: Nov 21, 2017 12:31AM - edited Nov 21, 2017 12:35AM by Lumpie
I watch for research news on breast cancer, treatments, etc., and frequently see interesting articles. There is a topic on BCO called "Breaking Research News from Breastcancer.org." One of the moderators suggested that another topic might be appropriate for posting links and synopses of reports on research found elsewhere. So here it is! Please post links to reports on research form reliable sources. Thanks for sharing!
Posts 421 - 450 (1,045 total)
Jul 18, 2018 01:42PM - edited Jul 18, 2018 02:03PM by marijen
Optimal Use With Adjuvant Endocrine Therapy Continues to Unfold in ER+ Breast Cancer
Published: Monday, Jul 09, 2018
"You're treating 20 to 30 patients with a drug for 10 years to help one patient," said Denes. "We have to figure out how to better identify that one patient and let the other patients live happy lives."
Jul 18, 2018 01:50PM - edited Jul 18, 2018 01:56PM by marijenFDA recalls heart drugs made by Teva, others over carcinogen impurity
Published: July 13, 2018 5:58 p.m. ET
Jul 18, 2018 08:24PM KPW3 wrote:Antibody-Drug Conjugate Gets Priority Review for Metastatic Triple-Negative Breast Cancer
Jul 18, 2018 08:25PM KPW3 wrote:FDA Approves Additional Breast Cancer Indications for Kisqali
Jul 19, 2018 10:03PM marijen wrote:This article explains how cancer treatment promotes cancer growth
Published Friday 1 December 2017
By Ana Sandoiu
Fact checked by Jasmin Collier
Jul 19, 2018 10:55PM brigid_TO wrote:Compared with subjects sleeping immediately after supper, those sleeping two or more hours after supper had a 20% reduction in cancer risk for breast and prostate cancer. A similar protection was observed in subjects having supper before 9 pm compared with supper after 10 pm,
Jul 20, 2018 01:07PM marijen wrote:
Breast Cancer Trials
Jul 20, 2018 09:39PM marijen wrote:
Doctors Give Patients 11 Seconds to Explain Reason for Visit
Jul 20, 2018 09:40PM marijen wrote:
Here's the skinny:
The study, published by JAMA Internal Medicine, evaluated nearly 1.6 million elderly Medicare holders hospitalized from Jan. 1, 2011 to Dec. 31, 2014. It determined that patients treated by female doctors had significantly lower rates of death and significantly lower rates of readmission to the hospital than patients who were treated by male doctors at the same hospital.
Jul 26, 2018 07:20PM Lumpie wrote:
I haven't been on in a while due to my very crazy schedule.
I saw the discussion about California labeling regarding substances "known to the State of California to cause cancer or reproductive toxicity." We've (almost) all seen these on nationally marketed products and the signs are ubiquitous in California. For many years, I have wondered, is California the only one demanding meaningful labeling or have they gone way overboard? The contrast of silence from all other quarters vs the abundance of labeling in California is jarring. It's hard to know where to start, but for those interested in reading more on the topic, here's a link to the American Cancer Society's briefing on the subject. https://www.cancer.org/cancer/cancer-causes/genera...
For those looking for additional perspectives, the organization Breast Cancer Action seems to be active in raising concerns related to environmental issues as possible causes of cancer. There is also a book on the topic, No Family History, by Sabrina McCormick. Not sure whether there is a forum on BC.org on the topic....?
Jul 26, 2018 07:28PM - edited Jul 26, 2018 07:29PM by LumpieSafety by Body Weight of Adjuvant Subcutaneous Trastuzumab for HER2+ Early Breast Cancer
I was thrilled to see that further study is being done on Subcutaneous Trastuzumab for HER2+ Breast Cancer. Alas, none of the study centers is in the U.S. (We need access to this mode of therapy in the states!) The link to clinical trial info is:
Jul 28, 2018 08:39AM Warrior2018 wrote:
That is very disturbing Marijen. I can’t believe the amount of toxins that exists!!! Ugh!
Jul 28, 2018 02:14PM marijen wrote:
Warrior it just impossible to avoid all the chemicals. I give up
Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: A Cancer Care Ontario and American Society of Clinical Oncology Clinical Practice Guideline: Journal of Clinical Oncology: Vol 35, No 18
Jul 28, 2018 09:34PM 7of9 wrote:
Marijen, Thank you...I go for my 5th Zometa infusion next Friday (every 6 months).
Jul 28, 2018 10:31PM MinusTwo wrote:
I've just had my 5th Prolia injection - also every 6 months.
Jul 28, 2018 10:37PM marijen wrote:
So 7of9 and Minus Two, you are getting these treatments as preventative? I had three yearly reclast, two before BC dx and 1 after. Don’t know why but my endocrinologist won’t give me more. I thought they made me feel better in the bones and muscles. Osteoporosis.
Jul 29, 2018 03:09AM marijen wrote:
Estrogen regulates the brain's fear response, protecting against PTSD
Jul 29, 2018 11:43AM MinusTwo wrote:
marijen - no I had osteoporosis from the treatments. I sent you a PM.
Jul 30, 2018 02:13PM 7of9 wrote:
yes, mine are preventative though diagnosed with mild osteo
Jul 31, 2018 01:42PM claireinaz wrote:
I know the value of estrogen re: regulating emotions, but I'm glad to have this article. At least I know my abject fear about everything at times, and my recurrent PTSD, isn't simply a character flaw.
Jul 31, 2018 01:43PM claireinaz wrote:
I know the value of estrogen re: regulating emotions, but I'm glad to have this article about estrogen and PTSD. At least I know my abject fear about everything at times, and my recurrent PTSD, isn't simply a character flaw.
Aug 1, 2018 01:56PM marijen wrote:
FDA Approves Magnetic Localization System for Lymph Node Biopsy in Breast Cancer
Aug 2, 2018 04:35AM Lumpie wrote:Association of Circulating Tumor Cells With Late Recurrence of ER+ Breast Cancer
Aug 2, 2018 04:36AM Lumpie wrote:Psychosocial Outcomes of Contralateral Prophylactic Mastectomy Among Women With Nonhereditary Breast Cancer
Aug 2, 2018 04:38AM Lumpie wrote:Impact of the Second Reader on Screening Outcomes at Blinded Double Reading of Digital Screening Mammograms
Aug 3, 2018 11:30AM Lumpie wrote:
CXCR4 inhibitors could benefit to HER2 but not to triple-negative breast cancer patients.
The CXCR4 receptor and its ligand CXCL12 (also named stromal cell-derived factor 1, SDF1) have a critical role in chemotaxis and homing, key steps in cancer metastasis. Although myofibroblasts expressing CXCL12 are associated with the presence of axillary metastases in HER2 breast cancers (BC), the therapeutic interest of targeting CXCR4/CXCL12 axis in the different BC subtypes remains unclear. Here, we investigate this question by testing antitumor activity of CXCR4 inhibitors in patient-derived xenografts (PDX), which faithfully reproduce human tumor properties. We observed that two CXCR4 inhibitors, AMD3100 and TN14003, efficiently impair tumor growth and metastasis dissemination in both Herceptin-sensitive and Herceptin-resistant HER2 BC. Conversely, blocking CXCR4/CXCL12 pathway in triple-negative (TN) BC does not reduce tumor growth, and can even increase metastatic spread. Moreover, although CXCR4 inhibitors significantly reduce myofibroblast content in all BC subtypes, they decrease angiogenesis only in HER2 BC. Thus, our findings suggest that targeting CXCR4 could provide some therapeutic interest for HER2 BC patients, whereas it has no impact or could even be detrimental for TN BC patients.