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Jan 27, 2012 01:01PM
Jan 27, 2012 01:05PM
Gentianviolet I read the two MSU papers. Very contradictory from all of the other clinical studies I assembled that date from 1998 to the present - 13 years of the same conclusions.
If you type in the name of each study you will be able to read it. I can't do a link to each because I downloaded them and this is the list on my word document. And, there were more studies that came to the same conclusion but I just ran out of time and energy to get and list them. I figured this was a substantial amount to present to my onc for discussion.
1998 Serum progesterone and prognosis in operable breast
1998 Estradiol and progesterone regulate the proliferation
of human breast epithelial cells.
1998 Progesterone inhibits growth and induces apoptosis in
breast cancer cells
2000 Progesterone effect on cell growth
2000 Hormonal regulation of apoptosis in breast cells and tissues
2004 Steroidal hormones and proliferation, differentiation
and apoptosis in breast cells
2008 Progesterone receptor inhibits aromatase and
inflammatory response pathways
2011 Progesterone inhibits growth and induces apoptosis in
2011 Effect of combined treatment with progesterone and
Tamoxifin on apoptosis
I am puzzled by the description of macrophages in the MSU paper. Macrophages are the body's garbage collectors.. They attack foreign substances including cancer cells and consume them. I have never heard of macrophages having any other purpose.
In a host of clinical studies the culprit that causes inflammation is ESTROGEN. It was shown over and over that progesterone had a mitigating effect on the inflammatory properties of estrogen. So I am again puzzled by the MSU paper which contradicts all of the clinical studies - and importantly many in vivo.
In addiiton, it has been shown that taking aspirin is beneficial for women who have had breast cancer and can prevent metastasis. Why? Because aspirin is an anti-inflammatory. And these are women who are NOT being given progesterone and have estrogen fed cancer cells.
It has been proven that women who are deficient in progesterone have problems with fertility and are also most likely to get breast cancer. After menopause is when most women get breast cancer and that is precisely when the progesterone levels have dropped way below estrogen levens, sometimes to zero.
A study I would like is to compare the hormone levels of women who DO get breast cancer with the hormone levels of women who do NOT. I realize it would take 20 years or more to get the data but perhaps there would be final convincing data regarding this puzzle.
I honestly don't know what to do. The Journal of Clinical Oncology report - recent - states that the absolute benefit of aromatase inhibitors is 2.9% reduction in recurrence Is this worth the side effects?
What if I never had to have my breasts cut off or go through chemo when all the time what I needed was to take progesterone? How do you argue with the results that chef127's sister had?
I am struggling with this and trying to find the answer. Good luck I know.
6/6/2011, IDC, Left, 2cm, Stage IIA, Grade 2, 1/1 nodes, ER+/PR+, HER2-
7/14/2011 Lumpectomy: Left; Lymph node removal: Left, Sentinel; Mastectomy: Left, Right
10/4/2011 Cytoxan (cyclophosphamide), Taxotere (docetaxel)
4/14/2012 Breast, Lymph nodes
2/20/2017, ILC/IDC, 2cm, Stage IV, metastasized to bone, Grade 2, 1/1 nodes, ER+/PR+, HER2-
2/21/2017 Femara (letrozole)