Topic: Halaven - Day 1

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Dec 14, 2010 03:05PM

Posted on: Dec 14, 2010 03:05PM

PJB wrote:

So, I'm the first person on this newly approved chemo at my med center. Lots of people who told me side effects.... They had a fancy dinner put on by the drug company last night so they all would know about it... :) Funny, no one gave ME steak and shrimp.  

Anyway, got hooked up to some saline as usual (altho, my onc's nurse wasn't sure why. She suggested since they charge so much, they had to do something... Apparently, it's unnecessary) The drug itself comes in a little syringe and they put it into the line over 5 minutes. Then, unhook you and you're done. All told, getting hooked up and waiting for pharmacy to get the drug over, etc., took about 30 minutes. 

Main SE's are neuropathy (have it, thanks to Ixempra), drop in blood counts (they say to plan on it next week), hair loss (already have that...), they'll watch liver enzymes (they're up from when I had my last Ixempra, but not too bad and tumor markers are the same... 

So, we'll see... I'll let you guys know what comes up down the road. I'll have it again next week, then a week off. Hopefully, it'll kill cancer like gangbusters.

Thanks for all your good wishes,

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Jan 13, 2022 06:38PM sadiesservant wrote:

Hi S3K5.. I answered you on the liver mets thread but will recap (and welcome Daywalker... there seems to be a bunch of us starting this one). I understand the trepidation completely. I was the same for some reason, even though I have also been on multiple lines of treatment. This is my fourth chemo since my MBC diagnosis in addition to multiple lines of endocrine treatments (including CDK inhibitors that are often not a walk in the park!).

I can happily report that I have had zero nausea. Hooray! I have had some aches, pains, headaches and fatigue. It has all been manageable for me with the fatigue being the most problematic. (I think my days of watching late night television are well and truly gone. LOL.) I'm waiting to see what my hair does as I've heard that thinning is most common rather than total hair loss but that doesn't seem to jive with what I have read here. I don't have neuropathy... yet but agree it might be a bit tricky to do the coldpack trick with a two minute push. I think if it's a problem their solution is to dial back the meds.

Hope you both have zero or minimal side effects and great results! I want us all to get those liver mets back in their box!

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/11/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/29/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/21/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/19/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/10/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
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Jan 13, 2022 09:25PM susaninsf wrote:

S3K5,

I was only on Halaven for 3 cycles. My scan showed a mixed bag of progression in the nodules in my lungs, shrinkage in one liver tumor, and progression in another. The non-cancerous problems in my lung were all better. Also shrinkage in a periaortic lymph node. As far as SEs, I didn't experience any while on Halaven.

I had already planned to switch to a clinical trial after the third cycle of Halaven so I haven't even talked to my MO about the scan results. I will see her on 1/25. I would probably have had to switch off of Halaven anyway given the progression in my lungs. It is my lungs that are giving me the most problems.

This will likely be my last posting on this thread but you all know where to find me on the clinical trial, lung, liver, and brain mets threads.

Hugs, Susan

Mets to brain, lung, liver, eye, bone. Currently on Epirubicin. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy; Lumpectomy (Left); Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel; Reconstruction (Right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy; Mastectomy (Right) Dx 3/29/2014, DCIS, Left, 4cm, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External Local Metastases 4/28/2014 Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External Local Metastases 1/8/2015 Radiation therapy: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External Local Metastases 11/27/2017 Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External Local Metastases 10/23/2019 Brain Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Chemotherapy 11/2/2021 Gemzar (gemcitabine) Hormonal Therapy 12/3/2021 Aromasin (exemestane) Targeted Therapy 1/6/2022 Targeted Therapy 6/24/2022 Enhertu (fam-trastuzumab deruxtecan-nxki) Chemotherapy 9/8/2022 Ellence (epirubicin) Targeted Therapy Verzenio Immunotherapy Tecentriq (atezolizumab)
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Jan 13, 2022 10:06PM denny10 wrote:

Round 1 , day 9, after second infusion. I was given a lower dose of steroids. I went to bed and got to sleep for a short time, but woke an hour later. I could not get back to sleep ,so here I am at 2.30 in the morning. The steroid does give me an energy boost. I got home did some vacuuming, decluttered a couple of drawers and sorted out my paper [pre pinterest ] recipes, before cooking the evening meal. I feel much better after this infusion, the omeprazole appears to have prevented the odd, queasy feeling I had last time.

This may be tmi, but just after I posted, day 7, I had bad diarrhea, which was a surprise, as for the past 5 years all the treatments I have had have made me constipated, ok now though. I stopped crying day 8 !!

S3K5 and Daywalker, I hope I have not frightened either of you and Halaven treats you well for a long time. ''knowledge is power''

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jan 14, 2022 02:41AM daywalker wrote:

Hi Denny, no worries, I agree knowledge is power! Here in South Africa we can use cannabis legally for medicinal reasons so I will try suppositories again, cannabis really worked wonders for side effects during the Taxol days.

My doctor is hopeful that Halavan will be helpful because I responded well to chemo in the past, I usually only stay on it for a few months and then can stay on herceptin for a while… with Halavan I understand that one stays on it for as long as it works.

S3K5, May this be a good and extremely useful treatment for you with very little and manageable side effects!

Xx

Stage 4 mets to liver, NEAD since April 2017. After Dosetaxol have been on herceptin and Aromasin indefinitely Dx 2/1/2017, IDC, Left, 3cm, Grade 2, 9/19 nodes, ER+/PR-, HER2- Surgery 2/10/2017 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 3/13/2017 Taxotere (docetaxel)
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Jan 17, 2022 07:09PM sadiesservant wrote:

Just a quick check in to see how folks are doing. Second infusion of the first cycle was uneventful. Hooray! In fact, I feel I have far less fatigue than I did following the first infusion. And, while I know it's early days, I actually feel improvement in a number of ways that make me feel hopeful that it's doing it's work.

Hope you are all doing well with minimal side effects and plenty of success.

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/11/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/29/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/21/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/19/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/10/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
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Jan 18, 2022 02:53AM piksie wrote:

Sadie, great news!

Denny, sorry about the surprise GI problem. I hope it was a fluke!

I have had three full cycles with minimal SEs. I have a 24-hour energy boost from the steroids, and the slightest amount of neuropathy beginning in my fingertips. I had a couple of mouth sores at the end of the first cycle, but started drinking ice water during infusion and have not had the problem since. I believe I'm also responding very well based on CA 15-3 and symptoms, but we likely won't scan for a couple more cycles.

I'm having to take an additional two weeks off after having COVID, so my fourth cycle will begin on 1/25 rather than 1/11. I find it very frustrating, but it's hospital protocol.

Daywalker, S3K5, hoping for a comfortable and effective kickoff.

Dx 12/12/2015, DCIS, Left, 6cm+, Stage 0, Grade 3, ER+/PR+, HER2- Dx 12/12/2015, IDC, Left, 6cm+, Stage IIB, Grade 2, 0/6 nodes, ER+/PR+, HER2- Surgery 1/27/2016 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left): Silicone implant Surgery 10/14/2016 Reconstruction (Left): Silicone implant; Reconstruction (Right): Silicone implant Dx 7/17/2018, IDC, Left, <1cm, Stage IIB, Grade 2, 18/18 nodes, ER+/PR+, HER2- Hormonal Therapy 7/29/2018 Zoladex (goserelin) Hormonal Therapy 7/29/2018 Arimidex (anastrozole) Surgery 8/17/2018 Lymph node removal; Lymph node removal (Left); Reconstruction (Left): Silicone implant Chemotherapy 9/12/2018 AC + T (Taxol) Dx 12/25/2018, IDC, Other, Stage IV, metastasized to bone, 18/18 nodes, ER+/PR+ Radiation Therapy 1/28/2019 Whole breast: Breast, Lymph nodes, Chest wall Local Metastases 1/28/2019 Radiation therapy: Bone Targeted Therapy 3/26/2019 Ibrance (palbociclib) Hormonal Therapy 6/14/2021 Faslodex (fulvestrant) Chemotherapy 9/30/2021 Xeloda (capecitabine) Chemotherapy 11/15/2021 Halaven (eribulin) Chemotherapy 4/1/2022 Gemzar (gemcitabine), Carboplatin (Paraplatin) Radiation Therapy 7/18/2022 Other part Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jan 20, 2022 12:28PM denny10 wrote:

Hello All, Day 15 , apart from the steroids, round 2 has been much esier on me . In fact I have been feeling so well I have been overdoing things on some days. It is lovely to wake up and feel ''I can .....'' today. I need to built up some stamina ( too much slobbing on the couch while on Abraxane) and learn to pace myself. I am pleased to say I still have my hair, my mouth is ok - using mouthwash, some gurgling in the GI area, neuropathy is the same. I did get a bit down for a day, but no unexplained tears. Now I have a week off. I feel I can handle this treatment at the moment, I just hope it is working.

Sadiesservant pleased to hear you are doing well on Halaven

Thanks for thinking of me Piksie. I hope your covid infection wasn't too bad and you get the next round on the 25th. I am quite scared of getting covid , due to previous pleural effusion, staying in and being 'careful' feels more restricting than chemo. Omicron seems to have peaked here in the UK, so I am hoping to get out and about and see more people soon.

Daywalker, S3K5 let us know how you are doing, if/when you start Halaven.


12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jan 20, 2022 02:43PM sadiesservant wrote:

Great to hear Denny. I can also say that the second infusion was easier with much less fatigue. I do feel it when I push too hard though and am a bit more tired now after a few days of work. My mouth is being problematic and the baking soda rinse didn't seem to help. No sores yet but it feels like I've eaten overly hot soup or something. The other thing I have noticed is some issues with sleep. I have no trouble getting to sleep but seem to be waking after a couple of hours. It takes a bit to get back to sleep. Anyone else have trouble with broken sleep?

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/11/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/29/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/21/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/19/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/10/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
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Jan 21, 2022 06:01AM denny10 wrote:

Hi Sadiesservant, I try to drink the recommended 2 litres of liquid each day. I have to get up in the night to go to the bathroom. (While there I use the mouthwash .) It varies how quickly I get back to sleep. If there is a problem I listen to the radio.

Enjoy what you can in the week ahead.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jan 21, 2022 08:11AM daywalker wrote:

Denny, I’m so glad to hear you are doing okay with side effects so far!

I’m starting treatment this coming Wednesday, funny enough my biggest worry is nausea, I absolutely hate nausea! But hopefully my doctor has some tricks up his sleeve… I wonder has any of you ladies ever had symptoms specific to the cancer in your liver? My liver looks very bad on scans now, multiple lesions and the biggest being 9cm, with some cirrhosis thrown in there for ‘special effects’, but my liver enzymes are only slightly elevated, and I feel the best I have felt in five years of stage 4 treatment… I hope Halavan arrives at the party before symptoms do!

All the best everyone x

Stage 4 mets to liver, NEAD since April 2017. After Dosetaxol have been on herceptin and Aromasin indefinitely Dx 2/1/2017, IDC, Left, 3cm, Grade 2, 9/19 nodes, ER+/PR-, HER2- Surgery 2/10/2017 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 3/13/2017 Taxotere (docetaxel)

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