Topic: Halaven - Day 1

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Dec 14, 2010 03:05PM

Posted on: Dec 14, 2010 03:05PM

PJB wrote:

So, I'm the first person on this newly approved chemo at my med center. Lots of people who told me side effects.... They had a fancy dinner put on by the drug company last night so they all would know about it... :) Funny, no one gave ME steak and shrimp.  

Anyway, got hooked up to some saline as usual (altho, my onc's nurse wasn't sure why. She suggested since they charge so much, they had to do something... Apparently, it's unnecessary) The drug itself comes in a little syringe and they put it into the line over 5 minutes. Then, unhook you and you're done. All told, getting hooked up and waiting for pharmacy to get the drug over, etc., took about 30 minutes. 

Main SE's are neuropathy (have it, thanks to Ixempra), drop in blood counts (they say to plan on it next week), hair loss (already have that...), they'll watch liver enzymes (they're up from when I had my last Ixempra, but not too bad and tumor markers are the same... 

So, we'll see... I'll let you guys know what comes up down the road. I'll have it again next week, then a week off. Hopefully, it'll kill cancer like gangbusters.

Thanks for all your good wishes,

Paula 

May 2004, Stage 2 IDC. Recurrence in 2005. On Femara til mets diagnosis in Feb 2009. On Faslodex 8/11. Brain mets in April 2012. Progression in liver 6/12. On to Etoposide. Dx mets, ER+/PR+, HER2-
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Mar 10, 2022 11:33AM denny10 wrote:

Hi, I am just back from my latest chemo. My oncologist asked to see me, as a rash, I have had twice in the past, has returned, before it has been linked with failure of treatment. I asked to continue with the halaven without an extra break, with the addition of the dreaded steroid and antihistamine to relieve the itch. I requested we hold off the filgrastim injections [ rash is a known side effect], but acknowledged I may have them next time as my neutrophils are low. I am feeling better than I have done in over a year and I know the lump in my breast is shrinking, but you never know what horrific path this nasty, secretive cancer will take you next. I will have a scan after the next complete round of halaven.

Just as covid restrictions have eased here, my best friend has been tested positive, so I wont be seeing her in the next two weeks. Along with the depressing news about Putins war, it's not been a good week. Sorry , I just need to offload.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Mar 11, 2022 02:58AM daywalker wrote:

Hi Denny, I’m sorry about the hard week. So many things weigh in on us as fragile yet precious human beings. So please offload all you want xx I feel you also on the Ukraine tragedy, that really is hard for me emotionally. As the Proverbs writer said The heart of man is desperately wicked, who can understand it? I see it play out right in front of my eyes on tv and the internet and it makes me feel helpless to be honest, especially since so much seemingly depends on strong yet wise leadership and these days that seems a bit thin on the ground.

I had a two week break between cycles, my haemoglobin and iron levels took a dive which explained that terrible tiredness I had for two weeks straight, my throat and eusophagus got badly inflamed and I’m not going to lie but I had my moments of nah this is not for me, oh and my first tumour marker test (which is an eye sore to look at) since treatment began showed no budging… at least it’s not up but still I was hoping for an Armageddon on those numbers haha xx my hubbie just informed me that we will be swimming in the ocean today (I live close to the sea and mountains here in Cape Town so am extremely grateful for the beauty of nature)

Apologies for the long post but know that myheart is with you ladies xx

Stage 4 mets to liver, NEAD since April 2017. After Dosetaxol have been on herceptin and Aromasin indefinitely Dx 2/1/2017, IDC, Left, 3cm, Grade 2, 9/19 nodes, ER+/PR-, HER2- Surgery 2/10/2017 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 3/13/2017 Taxotere (docetaxel)
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Mar 18, 2022 06:26AM denny10 wrote:

Hi, second attempt at an update!! I had chemo yesterday, neutrophils lowish but no filgastrim injections this time. My hair is shedding slowly, my taste is a bit off , no other mouth issues. Neuropathy the same. My rash has stopped spreading and is healing, but I have the weird sensations of steroid overdrive and antihistamine drowsiness. It will be good to get to sleep before 2am and not feel tired all the time when I stop the streoids next week, my week off.

I miss catching up with others on this site ,but you need some patience to navigate here at the moment. Good wishes for the weekend everyone.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 1, 2022 06:52AM denny10 wrote:

Hi, am I talking to myself? I have read elsewhere that Sadiesservant , sadly, has not had the outcome with halaven we would all wish for and is moving on to another treatment. My side effects are the same as before. I had another infusion yesterday , due one more before I go for a scan, scananxiety is starting.


12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 1, 2022 12:33PM sadiesservant wrote:

Yes, unfortunately Halaven is a bust for me. It’s nerve wracking when the list of treatments gets shorter and shorter but there are still a few left for me. I have a biopsy scheduled for the 12th and then may go back to Xeloda. Hopefully my bone marrow will hang in there as that was the reason I didn’t stay on it. At this point my primary concern is to get the liver mets under control.

Sending positive thoughts to all of you for a good long run on this drug.

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/11/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/29/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/21/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/19/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/10/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
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Apr 1, 2022 02:56PM daywalker wrote:

Hi Sadiesservant, so sad to see you have to move to a different treatment. I’m also moving to Xeloda next week due to horrible neuropathy caused by Halavan. I’m disappointed because it seems like Halavan was working due to dropping tumor markers. I hope Xeloda treats you well and works wonders on killing the bad cells xx


Denny, all the best with the scan, I trust the news will be positive xxx I’m having a scan this coming Monday… to be honest I’m just so tired of scanxiety I suspect my brain has switched off that part because I’m like whatever… which is very unusual for me!


All the best dear ladies! Xx

Stage 4 mets to liver, NEAD since April 2017. After Dosetaxol have been on herceptin and Aromasin indefinitely Dx 2/1/2017, IDC, Left, 3cm, Grade 2, 9/19 nodes, ER+/PR-, HER2- Surgery 2/10/2017 Lymph node removal; Mastectomy; Mastectomy (Left); Reconstruction (Left) Chemotherapy 3/13/2017 Taxotere (docetaxel)
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Apr 1, 2022 06:40PM sadiesservant wrote:

Shoot Daywalker! So sorry that you have to make the switch as well. One piece of advice, make sure to get a good moisturizer and keep your hands and feet well hydrated. Xeloda is notorious for hand and foot syndrome. I’m not looking forward to that aspect (goodbye stylish shoes!) but will deal with what I need to in order to get the liver under control.

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/11/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/29/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/21/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/19/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/10/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
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Apr 2, 2022 07:22AM denny10 wrote:

Hi Daywalker, Sadiesservant a hug each. I hope Xeloda works for you, I was on it for a short time , but that was when i was hr+ . The xeloda thread is active and if you have any concerns contact Denny123 , she was really helpful to me. I bought specialist creams and socks and never had foot problems. May your side effects be minor and it works for a long time.

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 11, 2022 02:48PM denny10 wrote:

Hi , as expected my scan result showed a mixed picture ; halaven worked on breast and lung mets but there was progression in liver. My oncologist is going back to last years biopsy to choose the next treatment , it must be difficult, as I have had all the obvious ones. He is talking of another chemo alongside immune therapy if appropriate. I wont be missing the rash the halaven aggravated the last 3 infusions and the worsening neuropathy. I now have a 2 weeks break at least to enjoy life.

Enjoy Easter your way. xx

12/2021 Stage IV TN Dx 2007, Left, Stage IIB, HER2- Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+ Hormonal Therapy Faslodex (fulvestrant), Femara (letrozole), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Apr 11, 2022 03:06PM sadiesservant wrote:

Darn it Denny. It’s interesting that three of us failed on Halaven at the same time. Sorry you’re also looking for another treatment. I’m still on a break as I wait for tomorrow’s biopsy. It’s anxiety inducing as, on top of the liver issues, I am having a lot of right shoulder and arm pain. I’m worried about possible involvement of the brachial plexus. I am so done with the constant pain!

I’ll be thinking of you. Let us know what you decide on. Hug

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/11/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/29/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/21/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/19/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/10/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other

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