Topic: Bone Mets Thread

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Jun 22, 2012 05:09AM - edited Oct 28, 2021 04:22PM by moderators

Posted on: Jun 22, 2012 05:09AM - edited Oct 28, 2021 04:22PM by moderators

Jac53 wrote:

I've started this thread after suggestions that it would be useful.

Mod Note: We have removed the original link as it is no longer viable. At one of our member's' recommendation we are offering this link as a resource for you.

https://youtu.be/YpFfLrITfEI


Jeannie. "You only live once, but if you do it right, once is enough." Dx 6/19/1995, 10/15 nodes Dx 2/18/2011, Stage IV, mets, ER+/PR+, HER2- Dx 7/2/2012, Stage IV, mets, ER+/PR+, HER2-
Log in to post a reply

Page 2697 of 2,717 (27,169 results)

Log in to post a reply

May 11, 2022 04:11PM rk2020 wrote:

Beth1965 - Yep, I’ve had both stable and progression at the same time. If the progression was singular and not intense, we waited until the next scan to see if it went away. In one case, it did not so I choose to radiate the spot of progression and stay on my current line of treatment as that has worked for some. Not me, but it was worth a try.

Sunnidays - I was on tamoxifen as adjuvant therapy for 3.5 years. When I was dx MBC my MO chose to move me to Fulvestrant which is a SERD along with Ibrance. You may find this article helpful although it won’t answer all your question. https://www.nejm.org/doi/full/10.1056/nejmoa052258#:~:text=The%20aromatase%20inhibitor%20letrozole%20is,breast%20cancer%20in%20postmenopausal%20women.

Surgery 5/1/2016 Lumpectomy (Right); Lymph node removal (Right): Sentinel Chemotherapy 6/20/2016 AC + T (Taxol) Radiation Therapy 9/1/2016 Whole breast: Right breast Hormonal Therapy 1/1/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 3/10/2020 Faslodex (fulvestrant) Targeted Therapy 3/28/2020 Ibrance (palbociclib) Radiation Therapy 2/22/2021 Other part Hormonal Therapy 9/1/2021 Arimidex (anastrozole) Targeted Therapy 9/1/2021 Verzenio Chemotherapy AC + T (Taxol) Hormonal Therapy Faslodex (fulvestrant) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy External Radiation Therapy Whole breast: Breast, Lymph nodes Local Metastases Radiation therapy: Bone
Log in to post a reply

May 11, 2022 08:05PM sunshine99 wrote:

sharware, wow, my was not nearly that bad. My blood calcium was moderately elevated before my MBC diagnosis. Enough for my PCP and MO to comment on it and once I got the MBC diagnosis, I stopped all supplements that might contain calcium.

my-sunny-side-up.com Cancer has progressed to my bones. I pray that it never enters my soul. Dx 11/2/2007, IDC, 3cm, Stage IIA, 0/3 nodes, ER+/PR+, HER2- Dx 3/26/2020, IDC, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 4/22/2020 Arimidex (anastrozole) Radiation Therapy 5/5/2020 External Local Metastases 5/5/2020 Radiation therapy: Bone Radiation Therapy 5/12/2020 External Local Metastases 5/12/2020 Radiation therapy: Bone Targeted Therapy 6/10/2020 Ibrance (palbociclib)
Log in to post a reply

May 11, 2022 09:28PM edge_of_no_return wrote:

sunshine99 - why were your bones leaching calcium into your blood? please forgive if this information is already previously in this thread. that is scary! and sharware - that you had the same experience, oh no.

also sharware - i do wish you the best with whatever you decide with your ro. so many choices to research, consider and choose from. maddening.

Dx 11/2016: right, IDC stage 1 grade 3, ER/PR+, HER2-. lumpectomy + sentinel dissection 1/2017. whole breast radiation only, opted out on meds. NED until 2021. MBC Stage IV Dx 9/2021: L1 vertebrae & possible rib 1. started arimidex & ibrance 12/2021, stopped 5/1/2022, re-evaluating. radiation scheduled for June 2022.
Log in to post a reply

May 11, 2022 09:39PM moth wrote:

breast cancer mets to the bone quite often cause calcium to be taken from the bone and leaked into the blood. It's a side effect of the cancer.

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- Surgery 12/12/2017 Lumpectomy; Lumpectomy (Left); Lymph node removal Chemotherapy 2/13/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole breast: Breast Dx 2/2020, IDC, Left, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/18/2020 Tecentriq (atezolizumab) Chemotherapy 11/25/2020 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 12/8/2020 External Hormonal Therapy 12/15/2020 Femara (letrozole) Radiation Therapy 3/2/2021 External Local Metastases 3/2/2021 Radiation therapy: Bone Targeted Therapy 1/1/2022 Trodelvy (sacituzumab govitecan-hziy) Chemotherapy 6/1/2022 Other
Log in to post a reply

May 11, 2022 11:29PM sunshine99 wrote:

Thank you, moth. I didn't know the answer to that. :)

On another note, I think I may have a UTI. Haven't had one in FOREVER, but there's some other stuff going on, too. My mind is wondering about ovarian cancer. I have a call into my PCP to at least get a urinalysis to see if there's anything growing in there. I have a bit of a fever, am super tired, and my back hurts more than usual. Am hoping it's just a UTI.

Carol

my-sunny-side-up.com Cancer has progressed to my bones. I pray that it never enters my soul. Dx 11/2/2007, IDC, 3cm, Stage IIA, 0/3 nodes, ER+/PR+, HER2- Dx 3/26/2020, IDC, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 4/22/2020 Arimidex (anastrozole) Radiation Therapy 5/5/2020 External Local Metastases 5/5/2020 Radiation therapy: Bone Radiation Therapy 5/12/2020 External Local Metastases 5/12/2020 Radiation therapy: Bone Targeted Therapy 6/10/2020 Ibrance (palbociclib)
Log in to post a reply

May 12, 2022 01:18AM emac877 wrote:

Sunnidays - I don't know that I can adequately answer your question to all the technical specifics but here is what was explained to me that made sense. Tamoxifen and other anti-hormonals block the estrogen from binding to the receptor site on cells. In effect, for estrogen positive tumors, it is starving them of the hormone source they need to grow and multiply. The CD4/6 inhibitors disrupt the process of cells replicating themselves. So the CD4/6 inhibitor isn't the same as Tamoxifen but they work synergistically. One blocks the nourishment source for tumor growth and the other works to prevent the tumor cells from being able to replicate. That's how I understood the explanation from my MO. If that helps.

Dx 2/8/2018, IDC, Right, 2cm, Stage IIB, Grade 2, 1/3 nodes, ER+/PR+, HER2- Surgery 3/22/2018 Lumpectomy; Lumpectomy (Right); Lymph node removal Chemotherapy 6/8/2018 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Radiation Therapy 8/26/2018 Whole breast: Breast, Chest wall Dx 12/4/2019, IDC, Stage IV, metastasized to bone Surgery 12/11/2019 Radiation Therapy 12/23/2019 External Local Metastases 12/23/2019 Radiation therapy: Bone Targeted Therapy 1/7/2020 Verzenio Hormonal Therapy 6/22/2021 Faslodex (fulvestrant)
Log in to post a reply

May 12, 2022 08:32AM beth1965 wrote:

rk2020- it seems so strange to me but I guess it happens. I will look into how much progression as you getting radiation on progressed areas seems like good idea as it does seem to be working elsewher

Looking for hope Surgery 2/2/2012 Lymph node removal; Lymph node removal (Left): Sentinel, Underarm/Axillary; Mastectomy; Mastectomy (Left); Mastectomy (Right) Radiation Therapy 8/15/2012 Breast, Lymph nodes Hormonal Therapy 9/28/2012 Faslodex (fulvestrant), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 11/8/2013 Aromasin (exemestane) Local Metastases Radiation therapy: Bone
Log in to post a reply

May 12, 2022 09:22AM sadiesservant wrote:

Beth, in my case it’s a bit like picking your battles. I have extensive bone mets - practically everywhere (spine, skull, sternum, hips, scapulas, ribs, etc.). I’m fortunate in that my cancer is slow growing but that means it slowly lays down sclerotic lesions which are often difficult to track for progression. (This is a topic I have debated with folks on here many times. There is a misunderstanding that all sclerotic mets are due to the bone healing due to successful treatment. That’s not the case in patients like myself. My bone, because the cancer is slow, takes the time to lay down scabs to “fix it” but that does not mean it’s not active cancer. This is opposed to lytic lesions which eat into the bone. This just confirmed in a conversation with my RO.) We watched with scans for many years and overall, other than at the very beginning of treatment when Arimidex failed, they have always been described as stable.

Over that time things did crop up that required radiation treatment. The most obvious was in September 2020 when I believe Faslodex and Verzenio started to fail. I began getting brutal headaches. By 11:00 AM they were absolute blinders. I had some skull mets which had caused a bit of facial numbness that we were watching. Scans didn’t show progression but steroids completely resolved the headaches which was a sign that there was brain swelling and in areas where there are a lot of nerves, a couple of millimeters of growth - difficult to measure - can cause problems. Five sessions of rads took care of it. Then by January (I knew from symptoms I was experiencing in December) I had liver mets.

Now the focus has shifted to my liver as it’s so much easier to track progression and/or success of the treatment. And while I am currently going through rads to deal with the lesion in my spine that is giving me grief, I’m good with that approach as visceral mets are more likely to cause issues. So, to sum, it seems that in my case I was able to maintain mostly stable for a long time with an occasional met that managed to sneak past the guard. Thankfully I have a great RO who is quick to blast the little blighters

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/11/2001 Lumpectomy; Lumpectomy (Right); Lymph node removal; Lymph node removal (Right): Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/29/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/21/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External Local Metastases 11/15/2017 Radiation therapy: Bone Hormonal Therapy 1/19/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External Local Metastases 8/2/2018 Radiation therapy: Bone Radiation Therapy 11/5/2018 External Local Metastases 11/5/2018 Radiation therapy: Bone Targeted Therapy 10/10/2019 Verzenio Radiation Therapy 11/3/2020 External Local Metastases 11/3/2020 Radiation therapy: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Other Chemotherapy 1/7/2022 Other
Log in to post a reply

May 12, 2022 02:21PM sunshine99 wrote:

sadiesservant. that's good information. I'm always a bit confused about the terms used with our bone mets.

Carol

my-sunny-side-up.com Cancer has progressed to my bones. I pray that it never enters my soul. Dx 11/2/2007, IDC, 3cm, Stage IIA, 0/3 nodes, ER+/PR+, HER2- Dx 3/26/2020, IDC, Stage IV, metastasized to bone, ER+/PR-, HER2- Hormonal Therapy 4/22/2020 Arimidex (anastrozole) Radiation Therapy 5/5/2020 External Local Metastases 5/5/2020 Radiation therapy: Bone Radiation Therapy 5/12/2020 External Local Metastases 5/12/2020 Radiation therapy: Bone Targeted Therapy 6/10/2020 Ibrance (palbociclib)
Log in to post a reply

May 13, 2022 05:13PM beth1965 wrote:

Sadie - I am quite similar extensive Mets basically everywhere head to toe. The skull Mets always scare me

Thanks for all the information and telling of your situation it be is very helpful

I am sorry to hear about your liver Mets I hope you are able to keep stable sending hugs and good wishes your way


Looking for hope Surgery 2/2/2012 Lymph node removal; Lymph node removal (Left): Sentinel, Underarm/Axillary; Mastectomy; Mastectomy (Left); Mastectomy (Right) Radiation Therapy 8/15/2012 Breast, Lymph nodes Hormonal Therapy 9/28/2012 Faslodex (fulvestrant), Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 11/8/2013 Aromasin (exemestane) Local Metastases Radiation therapy: Bone

Page 2697 of 2,717 (27,169 results)

Scroll to top button