How are people with liver mets doing?
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Lynne, so sorry to read about the chemo drug not working very well. You are one strong lady! Hope your MO has the next treatment plan chalked out. Would your MO recommend biopsy for the liver lesion?
My biopsy revealed that the tumor had changed from ER/PR positive to Negative. So I am triple negative now and my treatments will have to change accordingly.
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Grannax glad it went well what are diffuse mets?
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Alabama - good news on the clear scans, hope they stay that way.
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Nicole Diffuse mets means that they are spread all over the liver. When he was explaining that if he tried to use yiirium to get all of my mets from 3cm down plus 100 diffuse mets it would completely overwhelm my liver and I would go into liver failure. Kinda scary. This is the first time I've had diffuse mets but obviously it's not a good word to see on my report.
I'll just have to hope and pray that I respond to Halaven like you have. 💞
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Grannax, is there some tthought that the microwave ablation will have an abscopal effect on the diffuse mets? 'm assuming it's not practical to try to treat each met separately. I'm curious because my MRI showed 'numerous' mets, in addition to the two larger mets.
Also - am I correct that the y90 or ablation should 'kill' the tumor, while the CDK inhibitors 'suppress' the tumor? I'm trying to sort things out in my mind for future planning - whether there's a distinct advantage to one vs the other... when/if my largest tumor is small enough to treat locally. I'm also watching the local treatments thread - I just don't have anything to contribute.
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SeeQ,
I'll jump in here and hopefully Grannax or others will add.
I think that many interventional radiologists do think that taking out one or more lesions via ablation or Y90 can possibly have an abscopal effect on other mets. I have other mets in my liver in addition to the two that have been ablated. Since my ablation in 2019, they've done nothing but shrink ever so slightly.
To my understanding, CDK inhibitors suppress the tumor, and can cause stability or even some shrinkage. But even my interventional radiologist uses the term"kill" when he goes in for these ablations. On scans, there is usually a larger area than the original tumor, and the rim still lights up but the middle is described as necrotic tissue by the radiologists at my center.
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grannax the halaven is gonna work great 👍
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SeeQ, cdk inhibitors interfere with the tumor cell division. If I remember my cell bio I think it's from G1 to S phase of the cell division cycle. So it's not an instant killing of the cell, but rather preventing it from dividing. I think if it works well, existing tumor cells would eventually die off without being able to successfully divide.
I'm in the chemo chair with unreliable Wi-Fi so this is from my memory when I looked it up ages ago cuz one of my trial drugs is a cdk inhibitor (but when we got unblinded it turned out I was getting the placebo..)
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BevJen and moth - thanks for the information. I thought I had the gist of it. I'm trying to lay the groundwork (in my mind) for the eventual discussion with my MO. I've seen a few instances on BCO where someone is doing well on CDK inhibitor (Ibrance)...until they're not, and it seems like the little buggers come back with a vengeance. I may be reading too much into it, and maybe that's not the norm.
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Hi everyone,my daughters spilled water on my keyboard so i am using akeyboard on the screen which takes forever.
scan results show amazing results on my 11cm tumor, down to 5.6 cm. but two new lesions. why is there always a but...they are close together and could go either way with continued treatment.staying on lynparza another month and then maybe adding a platinum chemo...got two units of blood so should feel better tomorrow. looks like a fourth xmas will be spent with scans, new drugs and worry. tomorrow i will focus on the glas half full.
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Arolsson...YAY!!! and ...hrmmmm not so yay...
Are you on Halaven?? This is something I do not understand...if some tumors die from the treatment but then there are new ones wouldn't that suggest that the new ones are a different mutation???
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Amy,
Wow, that's some drop in size of the one tumor. And yay for the dropping markers as well.
A couple of things I would consider: could those smaller ones have been there and just not seen before? I always wonder about that. Also, as Nicole said, what about biopsying one of the new ones? Your cancer could have mutated further. Also, have you given up on local treatment? I think you were talking about that before. Perhaps you could think about that as well.
But yes -- you should celebrate the small victories. You are feeling pretty well, lynparza seems to be doing something good in your system, and you are considering other things that could help. Glass half full time.
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Arolsson---Well glad the one went from 11cm to 5cm--wow. But I too wonder about the others. Could they have been there all along and not seen due to the 11cm large one? I think I would give it more time on the current treatment to see if the other 2 shrink.
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So Lynprazna is for BRCA positive cancers correct?
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arolsson
I just want to validate your feelings. I had a somewhat similar report In Aug- big ones shrunk lots of new ones
Celebrate the big one shrinking and let it sweep over you with joy! It’s amazing and will lessenyour tumor burden.
It’s ok to be sad about the mixed results. It stinks! Cancer doesn’t care about holidays. 😪😤 Once you process it and mourn the loss of a total good report- You can wrap it up in a bow and let it go!!
I hope you can enjoy the now with your girls and when you get a new plan, you will be reenergized and feel better going forward.Dee
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Nicole- Yes, Lynparza is a PARP inhibitor. Used for BRCA positive.
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thanks all! MO thinks he can see the new mets on the previous scan.but why did they grow?maybe they were the same size but in shadow
oh well we shall see. yes i am on lynparza,did halaven a while back.
just had a kale smoothie--and then a chocolate bar. hugs all!
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My original liver mets only showed as a shadow on a CT scan with contrast. It wasn't until I had an abdominal MRI that they showed up more distinctly.
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Bev Jen Did the do your MW with just a needle or laparoscopic? 💞
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SeeQ, I've heard of the abscopal effect, maybe that is what my MO and IR are thinking/ hoping for with me. I hadn't even thought about it till you mentioned it. It's definitely helped me today to hope for that. I don't understand how it works, it sort of sounds like magic to me. I can use a little magic in my life. 💞
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Amy, great news about the bigger tumor shrinking! Hoping those other two were just hiding our and will shrink along with it.
Grannax, I think we can all use a little magic!
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Tomorrow is my Lipiodol procedure. Hoping
It's easy and that I won't remember a thing about it. Lol
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Grannax,
Good luck tomorrow. I'll be thinking good thoughts for you.
Do you know exactly how he's going to do this? You said that he was going to do it in his office -- does he have imaging equipment there? It sounded, from your description, that he was going to inject the poppyseed oil in his office.
Fingers crossed it all goes smoothly.
Bev
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Grannax, I am right there with you hoping it’s easy, painless, quick, and forgettable. I am sure you will do well. Your IR will take good care of you.
Hugs and prayers from, Lynne
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Grannax- Lipiodol? I read your post on here that you were having microwave ablation. The same thing? I truly have not researched all this.
Prayers for you, my friend.
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Grannax...good luck with you in pocket! Keep us posted
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Grannax- I like that, "It's easy and I won't remember a thing about it." I wish that for you, too. Thinking of you tomorrow.
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Grannax - glad to hear about tumor shrinking.
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Thanks everyone. My IR uses Lipiodol to light up the lesions he wants to Microwave. Evidently, it's poppyseed oil. It will be done through my artery ( transarterial) I think my wrist. Then on Wednesday, in the hospital he will do the MWA. I'm sure it will be CT guided. I am allergic to Iodine, contrast, so he will dose me up with steroids so that I won't turn into a lobster.
Yes , he has a procedure room in his new offices. He has all the equipment needed. But. It's only for procedures that can be done with mild sedation, like versed and fentenal, I guess he has a nurse anesthesist. Anything that needs an anesthesiologist he does in a hospital.
Yes, he knows me well and all of my allergies, etc. I'm in good hands.
I tried to get my son, the anesthesiologist, to get special privileges to come do mine on Wednesday but he said NO. "I do not do family" Well, bummer. I'm sure he's right but for me, that would be very comforting. 💞
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Grannax2, in your pocket for tomorrow. May it be just a blissful blurry nap.
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