Breaking Research News from sources other than Breastcancer.org
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Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis
Includes a long list of breast cancer symptoms, a Venn diagram of different categories, and analysis of how non-lump and non-breast symptoms may lead to delay.
https://www.sciencedirect.com/science/article/pii/S1877782117300565
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Debbew - is this the article you were referring to? Seems interesting if so. I'm currently in a "lump" + "non lump" symptoms group with this "new" thing that is going on with my Left nipple. Guess we'll see what my SO makes of it next week. Thanks for the article. The Venn diagram was easy to understand.
'Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis'
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Oops, I've fixed my link. Thanks for catching that! Yes, you found the same study. Thanks and hoping for a good outcome for you!
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I'd be curious to knw if any set of symptoms correlated with -type of cancer, -grade of cancer, -survival outcomes...?
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santabarbarian, symptoms like you might have experienced pre-dx? Good question.
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I had a red spot and a small fever, like a breast infection. I poked the area and sure enough a lump too. Came on all of a sudden from nowhere.
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my breast felt very itchy above where the tumor was but i could not feel a lump there... found on mammo
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Low Dose Naltrexone
Low dose naltrexone, referred to as LDN, is given as a capsule in the 3 mg to 4.5 mg range for cancer, as opposed to the 50 mg dose given for addiction. [1]
Low dose naltrexone might exert its effects on tumor growth through a mix of three possible mechanisms:
- By inducing increases of metenkephalin (an endorphin produced in large amounts in the adrenal medulla) and beta-endorphin in the blood stream;
- By inducing an increase in the number and density of opiate receptors on the tumor cell membranes, thereby making them more responsive to the growth-inhibiting effects of the already-present levels of endorphins, which induce apoptosis (cell death) in the cancer cells; and
- By increasing the natural killer (NK) cell numbers and NK cell activity and lymphocyte activated CD8 numbers, which are quite responsive to increased levels of endorphins. [2]
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Curcumin plays a vital role in fighting cancer
Sunil Pai, MD +
https://www.cancertutor.com/vital-role-curcumin-ca...0 -
Stolen from skyfly on another thread:
MIT supercharges cancer immunotherapy with a booster vaccine
"The team tested the vaccine on mice that had glioblastoma, melanoma or breast cancer, and saw a huge improvement in the T cell response. The mice were given about 50,000 CAR-T cells and then given a booster vaccine the next day, and then again a week later. In 60 percent of the mice, the tumors were completely eliminated. That's likely thanks to the boost in CAR-T cell numbers, which two weeks after treatment make up 65 percent of the total T cell population.
By contrast, in the mice that were given CAR-T cells but not the vaccine, there was no effect on the solid tumors and the CAR-T cells themselves were hard to detect in the bloodstream.
The technique also seemed to prevent the tumors from coming back later on."
https://newatlas.com/vaccine-supercharges-cart-cell-cancer-therapy/60550/
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Blood-Based Markers Key to Precision Medicine Approach in Breast Cancer
Mark E. Burkard, MD, PhD, discussed the significance of utilizing markers in the blood and highlighted emerging actionable mutations in breast cancer.
(Registration at onclive.com is free
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Researchers determine epigenetic origin of docetaxel-resistant breast cancer
"Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) have published a study in Molecular Cancer Research in which they identify methylation patterns associated with different subtypes of breast cancer... '[W]e have identified changes in the methylation of specific genes that can improve the classification of patient samples, thus helping us know whether they will respond to docetaxel treatment or not,' Dr. González-Suárez says. 'The differentially methylated genes identified can help us find treatments associated with the new subgroups.'"
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Broken heart syndrome may be linked to cancer, study suggests
Can cancer break your heart? A new study suggests that there's a link between cancer and a condition called broken heart syndrome.
The study, published Wednesday in the Journal of the American Heart Association, found that 1 in 6 people with broken heart syndrome had cancer, and that these patients in particular were more likely to die within five years, compared with broken heart syndrome patients without cancer.
Broken heart syndrome, which is also called stress cardiomyopathy or takotsubo cardiomyopathy, is a temporary condition that can be brought on by stressful situations. During broken heart syndrome, one part of the heart stops pumping normally, which may cause the rest of the heart to pump more forcefully, according to the Mayo Clinic.
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My 5-Month Interlude as a Disabled Professor
{A professor reflects on his period of disability. Many of us will relate to how our lives change when we are affected by a disabling condition.... such as cancer....}
"...my five-mouth travail provided a glimpse of an unnerving alternative reality for me as a classroom teacher. It caused me to see with new eyes how even seemingly insignificant things can create major obstacles for disabled faculty members and students as they go about trying to teach and learn on a college campus."
{No subscription required for this article but you may need to sign in.}
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Cancer Cells Switch Sugar for Fatty Acids to Spread Around the Body
Scientists have uncovered a crucial change in cancer cells that allows them to spread around the body – by switching from sugar to fatty acids to fuel their growth.
"We found that high levels of the protein AKR1B10 help tumour cells adjust to new environments as cancer spreads from the breast to other organs such as the lungs.
This research significantly improves our understanding of cancer cell metabolism and metastatic relapse and could lead to new avenues of exploration for new therapies and treatments for patients with metastatic breast cancer."
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Another way to knock out the nasties!
I hope some of the remarkable research being done gets the funding to work with humans! Would be good if Governments could speed up these protocols for terminal patients
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Cancer survivors are twice as likely to suffer from chronic pain
Researchers estimate over five million survivors struggle with the condition
A new study explored a unique symptom common to over five million cancer survivors: chronic pain.
According to researchers, cancer survivors are twice as likely to struggle with chronic pain compared with those who never had the disease.
"This study provided the first comprehensive estimate of chronic pain prevalence among cancer survivors," saidresearcher Dr. Changchuan Jiang. "These results highlight the important unmet needs of pain management in the large, and growing cancer survivorship community."
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Aggressive breast cancers more likely to hit black and younger women
Black and younger women face elevated risks of developing breast cancers that are not only aggressive but also less responsive to treatment, a new study confirms.
Conclusions: The results of the current study demonstrated that there is a significant burden of disease in TNBC diagnosed among women of color, specifically non‐Hispanic black women, and younger women. Additional studies are needed to determine drivers of disparities between race, age, and stage of disease at diagnosis.
https://onlinelibrary.wiley.com/doi/10.1002/cncr.32207
https://doi.org/10.1002/cncr.32207
{Don't they keep doing this research and finding the same thing?}
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Have Cancer, Must Travel: Patients Left In Lurch After Hospital Closes
Another example of an all too familiar trend — a rural hospital closes forcing patients to travel long distances to receive the care they need. The article looks at the impact on cancer patients in particular, as well as the community at large, when a local hospital like this shuts down. "Rural cancer patients typically spend 66% more time traveling each way to treatment than those who live in more urban areas, according to a recent national survey by ASCO."
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Billionaire Sean Parker is nerding out on cancer research. Science has never seen anyone quite like him
An interesting article that looks at how billionaire Sean Parker, known as an innovator and disruptor in Silicon Valley, is bringing his approach and money to cancer immunotherapy.
"While 'medicine in general can be so staid and cautious,' said D.A. Wallach, a life sciences investor who has known Parker since around 2011, 'you've got in Sean a billionaire who doesn't need to answer to anyone, who's incredibly intellectually engaged with this science, and who has believed for a long time that he knows what the answer's going to be.'"{Most Stat articles require a subscrition, but I was able to access this one.}
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{Don't they keep doing this research and finding the same thing?}
YES.
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'Big Three' Diagnostic Errors Account for Nearly 75% of All Serious Harm | HealthLeaders Media
KEY TAKEAWAYS
Diagnostic errors that led to death or permanent disability were linked with misdiagnosed cancers (37.8%), vascular events (22.8%) and infections (13.5%) — which led the researchers to refer to them as the 'big three.'
Half of the most-severe harm cases ended in patient death and the other half resulted in permanent disability.
Failures of clinical judgment caused more than 85% of the misdiagnosed cases.
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Paige touts study that validates its cancer diagnosis AI
Artificial intelligence-aided pathology company Paige said today that a new study has found that its computational decision-support systems can help clinicians diagnose and treat cancer. Published in Nature Medicine, a paper on the study describes an AI system for computational pathology that achieves clinical-grade accuracy levels. Researchers developed deep-learning algorithms to build a system that can detect prostate cancer, skin cancer and breast cancer with near-perfect accuracy, according to the paper.
https://www.nature.com/articles/s41591-019-0508-1
DOI: https://doi.org/10.1038/s41591-019-0508-1
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A differentiated approach to referrals from general practice to support early cancer diagnosis – the Danish three-legged strategy
This paper argues for and describes the organisation of the Danish three-legged strategy in diagnosing cancer.... urgent referral to diagnostic centres when we need quick and profound evaluation of patients with nonspecific, serious symptoms and finally easy and fast access to 'No-Yes-Clinics' for cancer investigations for those patients with common symptoms in whom the diagnosis of cancer should not be missed.
...that patients with an early-stage cancer present very differently in general practice and that a single focus on alarm symptoms or red flags might not be sufficient.
A study among Danish GPs...showed that in about one-third of cases, the GPs reported a quality deviation which was strongly associated with longer diagnostic intervals ...
...we saw that countries with a strong gatekeeper role also had the lowest cancer survival rates. This could suggest that in some countries where GPs were good gatekeepers, the GPs had become too reluctant to refer early to diagnostic investigations. Further, that access to diagnostic services in the initial phase was slow or rationed, resulting in patients not obtaining timely cancer investigations.
doi: 10.1038/bjc.2015.44
{After reviewing the above referenced article "Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis," I was interested to read about how other regions were approaching this challenge. This article describes the organisation of the Danish three-legged strategy.}
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Accelerate, Coordinate, Evaluate Programme: a new approach to cancer diagnosis
ACE was initiated in June 2014 as a 3-year NHS England initiative...The programme aims to address the NHS outcome of 'preventing people from dying prematurely', as well as improving overall patient experience along the diagnostic pathway. ACE supports many projects looking at the important role GPs and other primary care health professionals have in recognising symptoms of cancer and referring patients who need further investigation.
...one cluster is considering new approaches for patients that GPs find most difficult to place on a specific pathway, particularly those who present with vague but concerning symptoms.
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Tumor Infiltrating Lymphocytes and Breast Cancer
Many of you have read about the announcement a year or so ago from the National Institutes of Health. Dr. Steven Rosenberg, the leading authority on immunotherapy, a treatment he pioneered that uses a person's own immune cells to fight cancer, told the world about Judy Perkins. Judy participated in a clinical trial that was part of the larger NIH tumor infiltrating lymphocyte cancer trial run by Dr. Rosenberg. Judy had MBC that was not responsive to treatment. Since participation in the clinical trial, Judy has been NEAD. You can see Judy's presentation at the NBCC Leadership Summit 2017 here: https://nsp.performedia.com/node/16793 Her talk is about 12 minutes. Additional presentations follow.
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Something I came across. Sorry if already posted.
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For those interested in advocacy....
CPAT Webinar: Meet with Your Lawmakers During August Recess
Wednesday, July 24, 2pm Eastern
The August Congressional district work period is right around the corner. No need to travel all the way to Washington, DC. This is a great opportunity to meet with Members and their staff in a district office to discuss cancer care policy and legislation.
To help you get started, NCCS {National Coalition for Cancer Survivorship} will host a webinar on Wednesday, July 24 at 2:00pm EDT to discuss everything you need to know about conducting district meetings.The Cancer Care Planning and Communications Act (CCPCA) is also scheduled to be reintroduced soon, so we'll be reviewing this important legislation for you as well.
Instructions to Join the Webinar
You do not need to register for this webinar, just follow the instructions below to join on Wednesday. You may join the webinar as early as 1:50pm.
- Join the webinar here: https://join.startmeeting.com/nccs_web
- Type your name and email address, and click "Join."
Note: If prompted, you do NOT need to install the StartMeeting.com browser extension in order to join the webinar. - To listen by phone: Dial (781) 448-0068. (no access code needed)
- Or, to listen through your computer speakers:
- Note: If your device does not have a built-in microphone, and you do not otherwise have a headset or microphone plugged in, the system may not recognize your speakers and you will have to listen in by phone (see Step 3).
- Click the phone icon on the left side of the toolbar, and then select "Mic & Speakers"
- If a pop-up box appears in your browser requesting access to your microphone, click Allow. Your mic will be muted throughout the webinar.
If you encounter any problems dialing in, call (877) 553-1680 for customer care.
Can't make the webinar? If the webinar conflicts with your schedule, NCCS has you covered. We will post the recording and any associated resources on the main CPAT page as soon as it is available.
0 - Join the webinar here: https://join.startmeeting.com/nccs_web
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Not specific to breast cancer, but...
IBM has released three artificial intelligence (AI) projects tailored to take on the challenge of curing cancer to the open-source community...
IBM is working on the PaccMann algorithm [the first project] to automatically analyze chemical compounds and predict which are the most likely to fight cancer strains, which could potentially streamline this process...
The second project is called "Interaction Network infErence from vectoR representATions of words," otherwise known as INtERAcT. This tool is a particularly interesting one given its automatic extraction of data from valuable scientific papers related to our understanding of cancer...
The third and final project is "pathway-induced multiple kernel learning," or PIMKL. This algorithm utilizes datasets describing what we currently know when it comes to molecular interactions in order to predict the progression of cancer and potential relapses in patients.
https://www.zdnet.com/article/ibm-reveals-ai-projects-aiming-to-find-cancer-killing-drugs/
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