Hormonal Therapy for Breast Cancer May Lower Dementia Risk in Older Women

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Hormonal Therapy for Breast Cancer May Lower Dementia Risk in Older Women

Sep 9, 2024

Protection varied by race and decreased with age. Read more…

kaynotrealname

For real??? This is like completely the opposite of what HRT proponents say. Exciting to read!

murfy

Well, I think the HRT proponents may still have the last word! It was SERMs (ie, Tamoxifen) that had the most significant 'protective' brain effect (p<0.005) vs SERDs (no effect) and AIs (barely significant). Protective effect mostly seen in those younger users on anti-hormone treatment and younger users usually start with TAM. As TAM has antiestrogen effects on breast tissue, but estrogenic effects in brain, I can see SERM use having brain protective effects. As black women tend to develop breast cancer at an earlier age, and likely start treatment with TAM, I can also see why black women may show a greater brain protection effect. And, estrogen is brain protective by assisting in synapse formation and increased blood flow to brain cells.