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Topic: Anyone here with another primary cancer diagnosis??

Forum: Breast Cancer with Another Diagnosis or Comorbidity — Meet others who have breast cancer but also have another health diagnosis/comorbidity such as diabetes, MS, bipolar disorder, HIV or AIDS, Parkinson's Disorder, schizophrenia, etc.

Posted on: Mar 23, 2014 05:49AM

Sinsin wrote:

Anyone here with another primary cancer diagnosis?? Testing to see if I do right now. :(

I follow the Nemo Mantra, "Just keep swimming." Dx 1/14/2014, IDC, Stage IIB, Grade 2, 3/3 nodes, ER+/PR+, HER2- Surgery 2/12/2014 Lymph node removal: Left, Underarm/Axillary; Mastectomy: Left Chemotherapy 3/17/2014 Cytoxan (cyclophosphamide), Ellence (epirubicin) Chemotherapy 4/28/2014 Taxol (paclitaxel)
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Apr 25, 2017 10:38AM WJGS wrote:

Multiple things here. Meningioma in brain, high-grade DCIS in one breast, ADH in other breast, basal cell carcinoma, and multiple symptoms of a rare inherited neuropathy that is in my family. A novel mutation was found on a gene that everyone seems to be investigating as it has been linked to inherited neuropathy and a number of cancers, including breast, melanoma and non-melanoma skin cancers, prostate, and others. Traveltext - the gene is NDRG1, and a group of researchers at the University of Sydney have published a number of papers on it. The U.S. NIH has also identified the loci - 8q24 - as an area with increased risk for breast cancer, and other researchers have identified that loci as an areas of increased risk for prostate cancer.

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Apr 25, 2017 11:06AM Traveltext wrote:

Thanks WJGS, I'll try and find the paper on NDRG1.

As it happens, I have recently received a new gene test report from Color Genomics and they found no mutations for the following genes:

APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4*, CDKN2A (p14ARF), CDKN2A (p16INK4a), CHEK2, EPCAM*, GREM1*, MITF*, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2**, POLD1*, POLE*, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53

The only tested gene I have a problem with is BRCA1:C.135-62T>C which has a variation of unknown significance.

Since the Genetic Counsellor is sure there is a genetic reason for my breast and prostate cancer, I'll keep searching for eh gene!


Have breast & prostate cancer. NED both. More on Male BC

Dx 03/14, IBC, L. 2cm, S IIIB, G 2B, ER+/PR+, HER2- FEC x3, Taxol x3

Mx & 2/23 nodes 07/14

Rads x 33 09/14 and now on Tamox

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Apr 25, 2017 11:31AM Traveltext wrote:

Hmmm, just found this:

The association of NDRG1 and prognosis of cancer patients is controversial. Some studies have found that downregulation of NDRG1 in cancer worsens the prognosis of cancer. There is an inverse relationship in the levels of NDRG1 expression and the Gleason grade of the tumor in prostate cancer. A high PTEN (a tumor suppressor which positively regulates NDRG1) and NDRG1 expression improves survival rates in patients with breast and prostate cancer. HERE

Thanks again WJGS, it's real detective work!!


Have breast & prostate cancer. NED both. More on Male BC

Dx 03/14, IBC, L. 2cm, S IIIB, G 2B, ER+/PR+, HER2- FEC x3, Taxol x3

Mx & 2/23 nodes 07/14

Rads x 33 09/14 and now on Tamox

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Apr 25, 2017 11:32PM WJGS wrote:

I've probably read close to 100 papers referencing NDRG1; everyone suspects it plays a key role in cancer and schwann cell maintenance, but no one knows exactly what that role is. And it is difficult to determine, partially because it is ubiquitously expressed and also presumably because mutations on it are extremely rare - the one I have is novel, meaning it's never been recorded before. Also because, as you read, its impact varies, depending on what is going on both upstream and downstream - unexpected input may lead to unexpected output. The Sydney researchers aren't working specifically on prostate cancer but rather on the gene itself - they have a wealth of info on it, it may be worth checking it out.

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Apr 26, 2017 07:25AM Traveltext wrote:

WJGS do you have the link to the University of Sydney material? Can't seem to find it.

Have breast & prostate cancer. NED both. More on Male BC

Dx 03/14, IBC, L. 2cm, S IIIB, G 2B, ER+/PR+, HER2- FEC x3, Taxol x3

Mx & 2/23 nodes 07/14

Rads x 33 09/14 and now on Tamox

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Apr 26, 2017 08:07AM WJGS wrote:

Here's the link to the page of Sydney principal researcher Des Richardson; there are links on that page to some of his NDRG1 research.

http://sydney.edu.au/medicine/people/academics/profiles/d.richardson.php

Here's another link that may be of interest to you - from the ICGC (International Cancer Genome Consortium) portal with the top 20 breast cancer + prostate cancer mutated genes.

https://dcc.icgc.org/projects?filters=%7B%22projec...:%7B%22primarySite%22:%7B%22is%22:%5B%22Breast%22,%22Prostate%22%5D%7D,%22primaryCountries%22:%7B%22is%22:%5B%22United%20States%22%5D%7D%7D%7D&projects=%7B%22from%22:1%7D

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May 8, 2017 11:55AM 2FUN wrote:

I was DX with IDC sept 2016, endometrial CA nov, 2016 and after path report SHOWED DCIS as well as IDC, I had MX in march 2017. Heading back to work tomorrow and got call from surgeon that I have Hurthle cell neoplasm of the thyroid. Had the same thing 13 years ago. They need to remove the thyroid to look at the whole thing to see if it is malignant or benign. Last time it was benign. Let's hope this one is too. All my genetic testing showed no known genes linked to CA. Kind of gives you a false sense of security. I'm going to try to have my thyroid removed when I have my TE exchange and more margins removed. I'm really getting tired of all of this, but I'm not going to let this bring me down!

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May 9, 2017 03:16AM lekker wrote:

I'm sorry to hear that you're going through another round of thyroid issues. I hope it turns out to be benign. Please update us when you get your results. I hope your exchange goes well. I have to say, getting my implants was a good day for me - I got immediate relief from the discomfort of the TEs.

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal
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May 9, 2017 05:51AM 2FUN wrote:

lekker, can I ask how you discovered your colon cancer? I have a wierd feeling about my colon health. I'm trying to schedule my colonoscopy ASAP. I've put it of for 3 yrs now.

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May 11, 2017 12:09PM ThreeC wrote:

Basal Cell Carcinoma, Squamous Cell Carcinoma, Pappillary Thyroid Carcinoma, Hashimoto's Autoimmune Disease, and Breast Cancer newly diagnosed but still completing final diagnosis. No genetic testing yet.


Dx 4/11/2017, DCIS, Left, 3cm, Stage 0, Grade 1, ER+/PR+ Dx 5/23/2017, DCIS, Left, 5cm, Stage 0, Grade 1, ER+/PR+
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May 12, 2017 02:05AM lekker wrote:

2FUN - I had one episode of fairly significant bleeding after a bowel movement. I had a new primary care doctor through an HMO and she took it seriously. The polyp was about 1.5CM but only a small area at the top of it was carcinoma.

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal
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May 13, 2017 05:57AM GrendelDog wrote:

Stage IVa Thyroid (papillary) diagnosed in 2013 then the IDC in 2016. Did full genetic panel of tests, and nothing popped up, so it looks like I'm just lucky :)

Dx 9/12/2016, IDC, Left, 3cm, Stage IIIA, Grade 2, 4/18 nodes, ER+/PR+, HER2- Chemotherapy 10/6/2016 AC + T (Taxol) Surgery 3/21/2017 Lumpectomy; Lymph node removal: Underarm/Axillary Surgery 4/4/2017 Lumpectomy: Left Surgery 4/26/2017 Lumpectomy: Left Radiation Therapy Whole-breast: Breast, Lymph nodes Hormonal Therapy Arimidex (anastrozole)
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May 14, 2017 07:52AM lekker wrote:

GrendelDog - did you receive any radiation for the thyroid cancer that might've caused the breast cancer? I've heard of it going the other way around. Either way, sorry to see you here.

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal
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Jul 20, 2017 03:56AM Yoxter123 wrote:

So I have decided to be different .!!.. Diagnosed with ILC,IDC,LCIS,DCIS Left Breast May 2015, treatment as outlined in my Tagline. . Bumpy couple of years with CIPN ,AI side effects..... Was still continually exhausted .my onc is amazing and listened to my gut feeling that something wasn't right. PET showed ? On right kidney .....following various other scans .... They questioned RCC as one diagnosis .i opted for robotic partial nephrectomy as I wanted a conclusive answer. Pathology came back as clear cell renal carcinoma ...size on scan 1.3mm awaiting full path results........I am absolutely stunned.....the cancer word still hit hard....awaiting staging but can't believe I have another primary .Two months ago I did the color genomics 30 Gene screen similar to Traveltext above..... Came back with no variants detected ..contacting onc tomorrows to Bring forward appointment as I have so many questions.... Anybody know of anybody else that's developed kidney cancer after breast cancer?

However. Much we get scann anxiety ,,being scanned meant that this was found before I had symptoms ...a better sign for prognosis moving forward...

Anybody got any info on this or experience of ?? Pretty anxious right now ( back to sleepless nights worrying..it is 3.45 in the morning here in Australia)

Thankyou

Sorry for long essay !!

Dx 5/1/2015, ILC, Right, <1cm, Grade 1, ER+/PR+, HER2- Dx 5/1/2015, IDC, Right, 1cm, Grade 2, 1/24 nodes, ER+/PR+, HER2- Surgery 5/10/2015 Lymph node removal: Sentinel; Mastectomy: Right; Prophylactic mastectomy: Left Surgery 5/22/2015 Lymph node removal: Underarm/Axillary Chemotherapy AC + T (Taxol)
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Jul 20, 2017 05:27AM Lula73 wrote:

Hodgkins lymphoma in '87 - exploratory laparotomy w/splenectomy, chemo & rads

Melanoma in '04 - in office excision

Thyroid cancer in '04 - thyroidectomy

BC in '17 - skin & nipple sparing BMX w/immediate DIEP flap recon, Tamoxifen therapy til it tried to kill me with dvt & pulmonary emboli

Genetic testing positive for BRIP1 so oophorectomy planned with addition of hysterectomy due to the Tamoxifen usage.

There should be a hard & fast rule limiting the number of cancers you can be saddled with

-Lula Dx 1/2017, DCIS/IDC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 2/14/2017 Lymph node removal: Sentinel; Mastectomy: Left, Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 3/4/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 20, 2017 10:19AM lekker wrote:

Yoxter - I'm sorry you've received a second diagnosis but glad it was found before it caused any symptoms. I have a couple of friends that had a nephrectomy as their only needed treatment for kidney cancer and I hope you're done too!

Lula- wow you've been through a lot! I haven't studied the BRIP1 gene mutations. I hope you're done with cancer diagnoses.

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal
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Jul 20, 2017 12:11PM 2FUN wrote:

yoxter, I'm sorry you are going thru this. I had IDC and DCIS, and endometrial CA, and am awaiting pathology from thyroid ectomy that I had last week. Also had a "cyst" on my kidney, found during a scan. Your post has reminded me that even tho it doesn't look like anything substantial, I should be keeping an eye on it. My MO isn't surprised my genetics were normsl. She said she sees breast, endometrial, thyroid and kidney together, they just have not identified the genes. Hang in there. Every one I know with kidney CA is still alive 8 years later. They had kidney removed laporoscoply, and they have been fine.

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Jul 20, 2017 12:14PM 2FUN wrote:

lula, sorry you are adding to your list of diagnoses. I have just had my 4th surgery (in 9 months)on 5 body parts, so I am in the same boat, let's keep paddling, we have been thru a lot, and we will get thru this!

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Jul 24, 2017 12:39PM - edited Jul 25, 2017 04:35PM by 2FUN

I got good news, my pathology reports front the last surgeries were not malignant.Yay!

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Jul 24, 2017 02:24PM lekker wrote:

2FUN - woo hoo

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal
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Jul 25, 2017 02:42PM Yoxter123 wrote:

2FUN - that's great news

Dx 5/1/2015, ILC, Right, <1cm, Grade 1, ER+/PR+, HER2- Dx 5/1/2015, IDC, Right, 1cm, Grade 2, 1/24 nodes, ER+/PR+, HER2- Surgery 5/10/2015 Lymph node removal: Sentinel; Mastectomy: Right; Prophylactic mastectomy: Left Surgery 5/22/2015 Lymph node removal: Underarm/Axillary Chemotherapy AC + T (Taxol)
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Jul 25, 2017 02:45PM Yoxter123 wrote:

CA thanks for your kind words.. Saw surgeon yesterday -for follow up scan in three months if all good then move on to yearly scans

Dx 5/1/2015, ILC, Right, <1cm, Grade 1, ER+/PR+, HER2- Dx 5/1/2015, IDC, Right, 1cm, Grade 2, 1/24 nodes, ER+/PR+, HER2- Surgery 5/10/2015 Lymph node removal: Sentinel; Mastectomy: Right; Prophylactic mastectomy: Left Surgery 5/22/2015 Lymph node removal: Underarm/Axillary Chemotherapy AC + T (Taxol)
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Jul 28, 2017 04:41AM pepper43 wrote:

Been awhile since I've been on this thread! I had my right kidney removed and pathology report confirmed the mass was Chromophobe Renal Cell Carcinoma. So I'm an official member of the synchronous malignancy club (which makes me want to sing the phrase to the tune of The Police's Synchronicity). Hopefully the removal will take care of that.

Had my hopefully last surgery ever (or at least for a very long while - 5 in 25 months was a bit much. Got my TE's exchanged for squishies and nipples reconstructed. After my prophylactic ovary removal, I had lingering GI issues that prompted MO to order colonoscopy/endoscopy...which revealed a polyp that was pre-cancerous. I've had enough of the C word.

Dx 6/9/2016, IDC, Right, 2cm, Stage IIB, Grade 3, 1/4 nodes, ER+/PR+, HER2- Chemotherapy 6/24/2016 AC + T (Taxol) Surgery 12/9/2016 Lymph node removal: Sentinel; Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Radiation Therapy 2/6/2017 3DCRT: Lymph nodes, Chest wall Hormonal Therapy 3/20/2017 Femara (letrozole)
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Jul 28, 2017 06:54AM lekker wrote:

Pepper - sorry to hear about the kidney and polyp. Sounds like your body tends to make cancer. Have you had any genetic testing? I've been tested for pretty much everything but no mutations were found.

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal
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Jul 28, 2017 06:59AM pepper43 wrote:

I've been tested twice for genetics- no mutations found. I'm tending to think they haven't found the variation yet but who knows. Le sigh.

Dx 6/9/2016, IDC, Right, 2cm, Stage IIB, Grade 3, 1/4 nodes, ER+/PR+, HER2- Chemotherapy 6/24/2016 AC + T (Taxol) Surgery 12/9/2016 Lymph node removal: Sentinel; Mastectomy: Left, Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Radiation Therapy 2/6/2017 3DCRT: Lymph nodes, Chest wall Hormonal Therapy 3/20/2017 Femara (letrozole)
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Jul 28, 2017 07:58AM 2FUN wrote:

I feel for you papper. I'm recovering from 4 surgeries in 8 months for 3 cancers. My MO says he is sure the will find a genetic link soon. I also think of constantly low level exposure of carcinogens in my environment (that I don't know about) welcome to the club!

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Jul 28, 2017 08:36AM Lula73 wrote:

On the genetic testing for those of us with multiple cancers, they can also run the test for what they call Variants of Unknown Significance or VUS. They came up with 3 more variants when they ran it for mine after the initial test was run (they use the same blood).

-Lula Dx 1/2017, DCIS/IDC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 2/14/2017 Lymph node removal: Sentinel; Mastectomy: Left, Right; Prophylactic ovary removal; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Hormonal Therapy 3/4/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Jul 28, 2017 08:40AM Traveltext wrote:

Yes, I have two cancers and have test BRCA 1 with a VUS. These ambivalent results can be a worry until they are proven to mean something. Apparently there are thousands of VUS and it could take eons before they are all explained.


Have breast & prostate cancer. NED both. More on Male BC

Dx 03/14, IBC, L. 2cm, S IIIB, G 2B, ER+/PR+, HER2- FEC x3, Taxol x3

Mx & 2/23 nodes 07/14

Rads x 33 09/14 and now on Tamox

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Sep 9, 2017 02:16AM Yoxter123 wrote:

so back again !

Just had onc appt following CT and bone scan as getting bad bone pain and also due three month scan to check all clear. Had R partial nephrectomy in early June 2017 - pathology clear cell renal cell carcinoma 1.8 mm grade 2 .recovered well apart from bone pain .... Bone scan clear so happy dance and culprit probably the beloved exemestane little pill causing pain .

Ct scan absolutely knocked me breathless .... A new lesion .probably malignant bigger than the last one ...2.8mm has grown out of nowhere in weeks in the excision site of previous surgery .... See surgeon on Monday so trying with chemo brain to research multifocal RCC ... It's endless just when you have one thing in your head sorted and understood WHAM .....now they are looking at CT much more closely ...... My markers have been up all year.... Not mega high but in the 40's. I haven't slept in three days ...sorry for rant...trying to be calm and collected for my family but my sisters here will understand my massive anxiety.

Thanks for listening

Judi

Dx 5/1/2015, ILC, Right, <1cm, Grade 1, ER+/PR+, HER2- Dx 5/1/2015, IDC, Right, 1cm, Grade 2, 1/24 nodes, ER+/PR+, HER2- Surgery 5/10/2015 Lymph node removal: Sentinel; Mastectomy: Right; Prophylactic mastectomy: Left Surgery 5/22/2015 Lymph node removal: Underarm/Axillary Chemotherapy AC + T (Taxol)
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Sep 9, 2017 06:10AM lekker wrote:

Judi - so sorry to hear that you might be dealing with even more crap. Have you ever tried anti-anxiety meds to get you through the short term as you try to figure out exactly what that lesion is? Medicines like xanax, Ativan and Valium can be very helpful for a few days if you can tolerate them. Your onc should also be able to refer you to some support services. or you can just keep coming here to vent and we will listen! Please keep us posted

Colorectal carcinoma in situ January 2000 (age 30), and now this... Dx 7/2012, ILC, Right, 1cm, Stage IA, Grade 1, 0/2 nodes, ER+/PR+, HER2- Surgery 8/6/2012 Lumpectomy: Right Surgery 10/3/2012 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement Surgery 3/12/2013 Reconstruction (left); Reconstruction (right) Surgery 4/11/2013 Prophylactic ovary removal

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