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Topic: Stage 2 Sisters Club

Forum: Stage II Breast Cancer — Meet, share and support others with Stage II Breast Cancer

Posted on: Jul 27, 2013 03:13PM - edited Aug 8, 2013 01:34PM by NisaVilla

NisaVilla wrote:

Welcome to the newly formed Stage II Breast Cancer Club! And Thank You Mods for facilitating its creation.

Dx 3/22/2013, ILC/IDC, Left, 6cm+, Stage IIB, Grade 3, 0/3 nodes, ER+/PR-, HER2- Dx 3/22/2013, LCIS/DCIS, Right, 6cm+, Grade 2, 0/3 nodes, ER+/PR- Surgery 4/24/2013 Mastectomy: Left, Right Chemotherapy 6/24/2013 Cytoxan (cyclophosphamide), Taxotere (docetaxel) Hormonal Therapy 10/1/2013 Arimidex (anastrozole) Surgery 12/27/2013 Reconstruction (left); Reconstruction (right) Surgery 12/5/2014 Reconstruction (left); Reconstruction (right) Surgery 9/24/2015 Reconstruction (left): Fat grafting, Nipple reconstruction; Reconstruction (right): Fat grafting, Nipple reconstruction
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Posts 3481 - 3510 (3,559 total)

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Dec 5, 2017 11:34AM OCDAmy wrote:

Jay, yes have had 5 of 28 so far. How nice of you to ask. No issues yet, have gotten into the rhythm of the treatments now. It's just a hassle having to do this every day and still work. Luckily next week they are able to fit me in the mornings so I don't have to miss any work hours.

Maybe this is just scar tissue I am feeling. It is where the port was sitting in my chest, not the neck. Almost feels like it is still there just not so large. I guess I will wait a few more weeks and then ask my MO or PS about it.

Wondering if anyone else has had bladder control issues after chemo?

Dx 2/2017, IDC, Left, 4cm, Stage IIB, Grade 2, 2/13 nodes, ER+/PR+, HER2- Radiation Therapy Whole-breast Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery Lymph node removal; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement
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Dec 5, 2017 12:39PM - edited Dec 5, 2017 01:10PM by marijen

Create FileSee comment in PubMed Commons belowSci Rep. 2016 Jan 27;6:19771. doi: 10.1038/srep19771.

Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production.

Leoncikas V1, Wu H1, Ward LT2, Kierzek AM1, Plant NJ1.

Author information
1
School of Bioscience and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
2
Oncology DMPK, AstraZeneca, Alderley Park, Cheshire, SK10 4TG, United Kingdom.
Abstract

A major roadblock in the effective treatment of cancers is their heterogeneity, whereby multiple molecular landscapes are classified as a single disease. To explore the contribution of cellular metabolism to cancer heterogeneity, we analyse the Metabric dataset, a landmark genomic and transcriptomic study of 2,000 individual breast tumours, in the context of the human genome-scale metabolic network. We create personalized metabolic landscapes for each tumour by exploring sets of active reactions that satisfy constraints derived from human biochemistry and maximize congruency with the Metabric transcriptome data. Classification of the personalized landscapes derived from 997 tumour samples within the Metabric discovery dataset reveals a novel poor prognosis cluster, reproducible in the 995-sample validation dataset. We experimentally follow mechanistic hypotheses resulting from the computational study and establish that active serotonin production is a major metabolic feature of the poor prognosis group. These data support the reconsideration of concomitant serotonin-specific uptake inhibitors treatment during breast cancer chemotherapy.

PMID:
26813959
PMCID:
PMC4728432
DOI:
10.1038/srep19771
[Indexed for MEDLINE]
Free PMC Article
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Dec 5, 2017 01:06PM marijen wrote:

Platelets and Cancer:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41869...


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Dec 5, 2017 05:11PM Tpralph wrote:

Marijen very interesting article. I think I'll ask my mo about it.good news. My alnd was negative for anymore positive nodes!

Dx 3/10/2017, IDC, Right, 2cm, Stage IIB, Grade 2, 1/21 nodes, ER+/PR+, HER2- (IHC) Dx 4/10/2017, IDC, Right, <1cm, Grade 1, ER+/PR+, HER2- Surgery 5/18/2017 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Chemotherapy 6/28/2017 AC + T (Taxol)
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Dec 5, 2017 05:19PM marijen wrote:

Tp ralph, are your platelets low, in range, or high? I would be interested to know what your MO says. Here is a video of how the platelets “help” the cancer cells:

https://m.youtube.com/watch?v=eSwG5O_kiOQ


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Dec 6, 2017 06:27PM - edited Dec 6, 2017 06:37PM by Tpralph

marijen, surprisingly my platelets were normal at end of chemo darn it! not sure what they were prior to chemo; however did get a blood clot around picc so I'm thinking they weren't low at any point! hope the chemo and the upcoming tamoxifin will help destroy any other circulating (or at this point no longer circulating) cells

very interesting video and some info a little above me but it does explain why cancer patients are at risk for deep vein thrombosis and pulmonary embolisms

Dx 3/10/2017, IDC, Right, 2cm, Stage IIB, Grade 2, 1/21 nodes, ER+/PR+, HER2- (IHC) Dx 4/10/2017, IDC, Right, <1cm, Grade 1, ER+/PR+, HER2- Surgery 5/18/2017 Mastectomy: Right; Prophylactic mastectomy: Left; Reconstruction (left): DIEP flap; Reconstruction (right): DIEP flap Chemotherapy 6/28/2017 AC + T (Taxol)
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Dec 7, 2017 01:16AM jaymeb wrote:

Hi everyone


For the last two days, I've had pain in my hips, and lower back. It came on suddenly. It's more like a dull ache, not stabbing pains. Of course, my first thought is bone mets. I'm more uncomfortable sitting and laying down. When I'm moving around, it's much better. Could there be many reasons for this? I'm not as active as I should be, and before the pain came on suddenly, I had carried many bags upstairs, and a huge box of cat litter. I am on the tamoxifen, and wonder if joint aches could be a side effect. I've been doing well on this pill. Anyone ever had any dull aches, or joint pain after treatments of breast cancer? I'm somewhat worried. I feel like a big baby.











Dx 2/15/2017, IDC, Left, 1cm, Stage IIA, Grade 2, ER+/PR+, HER2- (FISH) Surgery 3/29/2017 Lymph node removal: Underarm/Axillary; Mastectomy: Left Hormonal Therapy 4/22/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 7, 2017 03:03AM PauletteK wrote:

Jay, I didn’t have much pains prior BC, now I have pains on my knees. I need to move it around in the morning, if I sit for long time, I feel the pains on my knees also. That’s all I can say.


Dx 4/1/2017, IDC, Left, 2cm, Stage IIB, Grade 2, 2/8 nodes, ER+/PR+, HER2- Surgery 6/15/2017 Lumpectomy: Left; Lymph node removal: Left, Underarm/Axillary Chemotherapy 7/19/2017 AC + T (Taxol) Radiation Therapy Whole-breast: Breast Hormonal Therapy Arimidex (anastrozole)
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Dec 7, 2017 06:46AM bravepoint wrote:

jaymeb - I'm the same, achy hips mostly which started with Taxol. Walking makes me feel better so I walk dogs early every morning. I do have new aches from Exemestane but they usually get better as the day goes on.

Gail Radiation Therapy 4/17/2016 Whole-breast: Breast, Lymph nodes, Chest wall Dx 8/8/2016, IDC, Right, 1cm, Stage IIA, Grade 3, 1/5 nodes, ER+/PR-, HER2- Surgery 8/29/2016 Chemotherapy 10/7/2016 Chemotherapy AC + T (Taxol)
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Dec 7, 2017 08:40AM ruthbru wrote:

Moving around is the best thing for aches. Of course, if you overdo it, that can make you sore/achy too. The rule of thumb for anything (except, of course, you are in agony, running a high fever or something acute, is to wait two weeks before you even start to think about checking with a doctor. Jay, I would be willing to bet it's from your unaccustomed trips up & down the steps carrying heavy loads.

"Invisible threads are the strongest ties." Friedrich Nietzsche Dx 2/2007, Stage IIA, Grade 3, 0/11 nodes, ER+/PR-, HER2-
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Dec 7, 2017 10:02AM marijen wrote:

MT LEPT says move it to lub it. It has to do with the synovial fluid in the joints.

Tpralph, I’m glad the video was helpful.

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Dec 9, 2017 12:54AM jaymeb wrote:

Hi ladies


Thanks for your thoughts, and responses. It made me feel better, but my mind still goes to "what if it's this"? Can't help it. I feel like I'm always going to have this dark cloud over my head. Still having the aches in the joints, but today, it eased off a little.


ruthbru

My mother, as well thinks it's my trips up and down the stairs, also in heels, no less. It's funny you mentioned two weeks, and I already had an appointment with my onco on the 18th. Didn't realize it until I looked at my calendar today.

PauletteK

I never had any accute pains before breast cancer as well, so this just scares me some. I will feel better when I see my onc.


bravepoint

I wish I could get up early, maybe I need to trade in my two cats for a dog. Lol. My daughter and I love animals. She would love another cat, and a dog. One of our cats acts more like a dog. She runs out every chance she gets. What breed are your dogs?


Oh, to those of you who have pets, have at anytime they got on your lap, and laid their paw on your chest? My cat does this to me every time I sit on the couch, or lay in bed. This has been going on since my diagnosis. I believe our beloved pets just know their owners.


marijen


Love that, move it to lub it. I have to ask, what is synovial fluid? Never heard of it.



Dx 2/15/2017, IDC, Left, 1cm, Stage IIA, Grade 2, ER+/PR+, HER2- (FISH) Surgery 3/29/2017 Lymph node removal: Underarm/Axillary; Mastectomy: Left Hormonal Therapy 4/22/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 9, 2017 01:09AM PauletteK wrote:

Jay, my dog knows when I’m sad, during the last few months whenever I started crying, my dog will run next to me and look at me or lay right beside me.

How are you feeling today? Is the pains still the same?


Dx 4/1/2017, IDC, Left, 2cm, Stage IIB, Grade 2, 2/8 nodes, ER+/PR+, HER2- Surgery 6/15/2017 Lumpectomy: Left; Lymph node removal: Left, Underarm/Axillary Chemotherapy 7/19/2017 AC + T (Taxol) Radiation Therapy Whole-breast: Breast Hormonal Therapy Arimidex (anastrozole)
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Dec 9, 2017 01:45AM jaymeb wrote:

Hey PauletteK




My pain was better today, however, last night was awful. I'm at my mother's house which is two hours away from mine. So, I had to pack in a hurry, always pack too much. I'm on the second level of my complex, so many trips up and down the stairs carrying luggage. My ex-husband always did that. I miss being married, however we get along great. He has been right there for me through my journey, and we've been divorced for four years. Thank you so much for asking. So many wonderful women on this forum. I can gaurentee your dog knows exactly what's going on with you. They are very smart, and perceptive. I've read stories where women who have a dog, or cat gave them signals that something was wrong before they were diagnosed. What would we do without our pets???? On another note, how are you doing? You're supposed to be starting radiation this month. When do you start?

Dx 2/15/2017, IDC, Left, 1cm, Stage IIA, Grade 2, ER+/PR+, HER2- (FISH) Surgery 3/29/2017 Lymph node removal: Underarm/Axillary; Mastectomy: Left Hormonal Therapy 4/22/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 9, 2017 01:55AM jaymeb wrote:

Molly50


I owe you an apology, and I feel so stupid. I asked you how you were doing on rads, and realized you did that two years ago. So sorry.🤦♀️🤦♀️

Dx 2/15/2017, IDC, Left, 1cm, Stage IIA, Grade 2, ER+/PR+, HER2- (FISH) Surgery 3/29/2017 Lymph node removal: Underarm/Axillary; Mastectomy: Left Hormonal Therapy 4/22/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 9, 2017 01:58AM jaymeb wrote:

🤦♀️🤦♀️🤦♀️

Dx 2/15/2017, IDC, Left, 1cm, Stage IIA, Grade 2, ER+/PR+, HER2- (FISH) Surgery 3/29/2017 Lymph node removal: Underarm/Axillary; Mastectomy: Left Hormonal Therapy 4/22/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
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Dec 9, 2017 04:32AM - edited Dec 9, 2017 04:35AM by Hope99

How are you sisters? hope all of you will be fine .

I will start chemo on MONDAY, pre-chemo clinic will be tomorrow and really I'm afraid and cry too much . I'm grade 3, IDC, Stage 2A according to my doctor, took biopsy from my auxilary node and doctor told me you have 2 positive nodes with 2.3-2.5 cm tumour. my protocol is FEC 3 cycles, taxotere 3 cycles respectively . there is no much information in this board about FEC's SIDE EFFECT. I have one question in my mind: can Chemo reduce the number of nodes involved from two to one? can chemo reduce the size of tumor effectively? specially I focusing on nodes, because the doctor told me we are alarm if we see nodes involved, may cancer break lymph system and goes to the body through blood, I don't know how much seriously is that!? that's why I'm worry, hope chemo can do that, no ideas :(

why the doctor are worry too much and in the same time he said stage 2A,2B are early-satge in breast cancer? something wrong!!

Dx 9/14/2017,IDC, Right, 2.5 cm, high suspection multicentric and auxialry nodes 1.8 cm, ER+/PR+, HER2-
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Dec 9, 2017 06:31AM - edited Dec 9, 2017 06:34AM by bravepoint

JaymeB - I have 3 German Shorthaired Pointers, Terra 15 1/2 years, Dante 4 years and Rayne 9 years. They are very high energy so need that walk/run every morning! They were a huge comfort to me during my year of surgery then chemo then rads. Whenever I lay down to rest, they snuggled in tight beside me.


Hope99 - Sounds like you are doing chemo before surgery. I did surgery first. The stage of your 2A or B refers partially to the size and lymph node involvement. The grade tells you how aggressive the tumor is growing. Good luck with your chemo. Drink lots of water and rest when you need to!

Gail Radiation Therapy 4/17/2016 Whole-breast: Breast, Lymph nodes, Chest wall Dx 8/8/2016, IDC, Right, 1cm, Stage IIA, Grade 3, 1/5 nodes, ER+/PR-, HER2- Surgery 8/29/2016 Chemotherapy 10/7/2016 Chemotherapy AC + T (Taxol)
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Dec 9, 2017 07:13AM Legomaster225 wrote:

Hope99. Chemo can be very effective. Everyone’s cancer responds differently but I had a positive node pre chemo (confirmed with biopsy) and it was cancer free at surgery. My 3.5cm tumor had only “rare” cancer cells remaining. I was staged as IIB prior to surgery. Don’t give up hope. I hope your chemo goes well. The anticipation is difficult

Dx 12/3/2016, IDC, Right, 3cm, Stage IIB, Grade 2, ER+/PR+, HER2- Chemotherapy 1/19/2017 AC + T (Taxol) Dx 6/22/2017, IDC, Left, <1cm, Stage IB, Grade 1, ER+/PR+ Dx 6/22/2017, DCIS, Left, <1cm, Stage 0, Grade 1 Surgery 6/22/2017 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Radiation Therapy 8/22/2017 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 10/17/2017
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Dec 9, 2017 07:56AM Hope99 wrote:

hello Gail,

you are right, chemo first then surgery, this is what the doctor said, he told me I gave you 6 cycles due to nodes involved, two nodes according to biopsy,US and mammogram. how they know by biopsy? I don't know how!

hello legomaster,

how you find a positive node through biospy and nevgative after surgery?! strange, do you mean the chemo kills cancers in nodes and tumour? appreciate your respond dear.



Dx 9/14/2017,IDC, Right, 2.5 cm, high suspection multicentric and auxialry nodes 1.8 cm, ER+/PR+, HER2-
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Dec 9, 2017 08:09AM bravepoint wrote:

Hope 99 - They can see "suspicious" nodes in an ultrasound. Did they biopsy the nodes? I had a sentinel node biopsy on the morning of my surgery. They also injected a blue dye into the edge of my nipple right before surgery to track any nodes that were cancerous. I had 1 of 5, the closest one to my breast.

Gail Radiation Therapy 4/17/2016 Whole-breast: Breast, Lymph nodes, Chest wall Dx 8/8/2016, IDC, Right, 1cm, Stage IIA, Grade 3, 1/5 nodes, ER+/PR-, HER2- Surgery 8/29/2016 Chemotherapy 10/7/2016 Chemotherapy AC + T (Taxol)
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Dec 9, 2017 08:15AM Hope99 wrote:

no Gail, my biopsy not taken during surgery, the doctor used very thin needle to take that biopsy in 15 min . after one week, oncologist doctor told me you have two positive nodes!

Dx 9/14/2017,IDC, Right, 2.5 cm, high suspection multicentric and auxialry nodes 1.8 cm, ER+/PR+, HER2-
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Dec 9, 2017 08:53AM bravepoint wrote:

Hope 99 - Was the biopsy of the nodes then or the lump?

Gail Radiation Therapy 4/17/2016 Whole-breast: Breast, Lymph nodes, Chest wall Dx 8/8/2016, IDC, Right, 1cm, Stage IIA, Grade 3, 1/5 nodes, ER+/PR-, HER2- Surgery 8/29/2016 Chemotherapy 10/7/2016 Chemotherapy AC + T (Taxol)
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Dec 9, 2017 08:56AM Hope99 wrote:

BOTH, FIRTS THEY TOOK FROM LUMP AFTER THAT THEY TOOK FROM AUXILIARY NODE

Dx 9/14/2017,IDC, Right, 2.5 cm, high suspection multicentric and auxialry nodes 1.8 cm, ER+/PR+, HER2-
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Dec 9, 2017 09:13AM OCDAmy wrote:

Hope,

I had a lymph node that was enlarged in the ultrasound. It was biopsied along with the lump and they found cancer cells in the node. During surgery I had 13 nodes removed and 2 were positive. By having chemo first they are trying to kill the cancer cells and hopefully when you have suegery the cancer will not be present in the nodes.

Dx 2/2017, IDC, Left, 4cm, Stage IIB, Grade 2, 2/13 nodes, ER+/PR+, HER2- Radiation Therapy Whole-breast Chemotherapy Cytoxan (cyclophosphamide), Taxotere (docetaxel) Surgery Lymph node removal; Mastectomy: Left; Prophylactic mastectomy: Right; Reconstruction (left): Tissue expander placement; Reconstruction (right): Tissue expander placement
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Dec 9, 2017 09:23AM Molly50 wrote:

jaymeb, no apologies necessary. It's a lot of people to keep track of.

54 years old. Chek2 mutation. Family history of BC. Oncotype Dx 13 Extensive LVI Dx 6/8/2015, IDC, Left, 2cm, Stage IIB, Grade 2, 2/9 nodes, ER+/PR+, HER2- (FISH) Dx 7/29/2015, DCIS, Left, <1cm, Stage 0, Grade 2, ER+/PR+ Surgery 7/29/2015 Lumpectomy: Left; Lymph node removal: Underarm/Axillary Surgery 9/4/2015 Mastectomy: Left; Reconstruction (left): Tissue expander placement Hormonal Therapy 10/13/2015 Arimidex (anastrozole) Radiation Therapy 10/20/2015 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 4/22/2016 Aromasin (exemestane) Surgery 7/22/2016 Prophylactic mastectomy: Right; Reconstruction (right): Tissue expander placement Surgery 3/21/2017 Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant
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Dec 9, 2017 10:20AM moth wrote:

bravepoint, I <3 your GSPs!
I used to have 3 dogs but now I'm down to 1, my old but still active field English Setter.

Dogs are my thing - was doing rescue fostering, and recreational rally O and agility etc. Dh said right away for dx "you're going to need more dogs" lol. But I don't know if it's the right time. Last couple years with losing the other 2 have been hard and the energy/exercise mismatches when you have multiple dogs at various age/health status is hard to juggle. But maybe he's right....

Dx at 50 Dx 12/4/2017, ILC/IDC, Left, 2cm, Stage IIA, Grade 3, ER+/PR-, HER2- Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel
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Dec 9, 2017 10:59AM bravepoint wrote:

moth - A fellow Canadian and a dog lover! Awesome! Dogs are my thing too. I used to have horses as well but it's easier to take the dogs to competitions than it was to take the horses. I do a lot of agility with my 2 younger dogs and teach it as well. It kept me going last winter when i was going through months of chemo. I have done just about every dog sport there is but now with less energy agility is my focus. I have always had multiple dogs and they exercise each other somewhat when they play. Maybe not the time doe you to get a puppy but there are lots of pointing dogs needing rescued in Canada. Ther is a rescue devoted to them if you want i can dig up the link.

I just looked at your stats. Pretty similar to mine though I see you are newly diagnosed. Feel free to ask any questions.

Gail Radiation Therapy 4/17/2016 Whole-breast: Breast, Lymph nodes, Chest wall Dx 8/8/2016, IDC, Right, 1cm, Stage IIA, Grade 3, 1/5 nodes, ER+/PR-, HER2- Surgery 8/29/2016 Chemotherapy 10/7/2016 Chemotherapy AC + T (Taxol)
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Dec 9, 2017 11:13AM ruthbru wrote:

Hope, it's the fast growing grade 3 cells that chemo is the most effective in killing off! So, since you are doing chemo, grade 3 is actually a POSITIVE thing.

"Invisible threads are the strongest ties." Friedrich Nietzsche Dx 2/2007, Stage IIA, Grade 3, 0/11 nodes, ER+/PR-, HER2-
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Dec 9, 2017 05:08PM Legomaster225 wrote:

Hope, yes, had biopsy of my lymph node last December. a marker was placed at that time. In June, after chemo that node was one of 4 removed. It had no cancer in it upon removal. The chemo did kill the cancer. The goal for ore adjuvant comes chemo was to clean up the lymph node and reduce the tumor. It was very effective. My cancer on that side was 23%ER/10%PR so I think that helped the response. It was Grade 2, Stage IIB.

The pathology report identified a 3.5cm tumor bed but very sparse living cancer cells remaining. It is kind of comforting to know that the chemo worked well which I guessis one advantage of having chemo prior to surgery.

Dx 12/3/2016, IDC, Right, 3cm, Stage IIB, Grade 2, ER+/PR+, HER2- Chemotherapy 1/19/2017 AC + T (Taxol) Dx 6/22/2017, IDC, Left, <1cm, Stage IB, Grade 1, ER+/PR+ Dx 6/22/2017, DCIS, Left, <1cm, Stage 0, Grade 1 Surgery 6/22/2017 Lymph node removal: Sentinel; Mastectomy: Left, Right; Reconstruction (left): Silicone implant; Reconstruction (right): Silicone implant Radiation Therapy 8/22/2017 Whole-breast: Breast, Lymph nodes, Chest wall Hormonal Therapy 10/17/2017

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