Topic: Triple Negative Stage IV

Forum: Stage IV/Metastatic Breast Cancer ONLY — Please respect that this forum is for members with stage IV/metastatic breast cancer ONLY. There is a separate forum for caregivers and friends: Caring for Someone with Stage IV or Mets.

Posted on: Feb 1, 2013 01:56AM

Posted on: Feb 1, 2013 01:56AM

Renae64 wrote:

This is a way for us to find each other, please add your post so everyone can be found. We can discuss on this thread (hope this works out!)

Dx 4/3/2012, IDC, 3cm, Stage IV, Grade 3, 0/3 nodes, ER-/PR-, HER2- Surgery 4/23/2012 Lumpectomy: Right
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Apr 14, 2022 07:14PM nicolerod wrote:

Im sorry Moth I feel the same way ....in 5 days I hit my 3 year mark...running out of time and treatments. Will you look at a trial?

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 Cryoblation on 2 of 4 tumors in liver. Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy; Mastectomy (Left); Mastectomy (Right)
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Apr 15, 2022 04:30AM ap3 wrote:

Oh Moth, I'm so sorry to hear that Trodelvy might not be working well for you. It's such a horrible disease. Fingers crossed that they find something that will work for you.

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Apr 25, 2022 05:22AM nicolerod wrote:

Moth I see I did respond to you here about the possible progression. Hoping that you just need more time on T.

Is anyone doing the Keto diet? I was considering it based on a great informative video about the metobolic side of cancer (I will post a link to video below). but concern is about blocking the fatty acid pathway. I know that if we cut carbs and sugar which is good but it can then make the cancer just pick a different pathway to eat from....

https://www.youtube.com/watch?v=06e-PwhmSq8&t=2336s

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 Cryoblation on 2 of 4 tumors in liver. Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy; Mastectomy (Left); Mastectomy (Right)
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May 10, 2022 09:09AM ap3 wrote:

Well, it looks like my wife is out of this thread, for now at least. Her biopsy came back and she has gone from TN to ER+ 8/8.

It's weird how this disease works. She's being treated as ER+ now, but I will make sure they biopsy *anything* new that turns up. I'm not in any way convinced that the TN cells are done with her yet, but our fingers are crossed.

How often does everyone get biopsies? Is it every new occurance?

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May 10, 2022 02:13PM nicolerod wrote:

That is the first I have ever heard of someone going from TN to ER+

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 Cryoblation on 2 of 4 tumors in liver. Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy; Mastectomy (Left); Mastectomy (Right)
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May 10, 2022 02:43PM rosie24 wrote:

ap3, very interesting that your wife went from TN to ER+. I recently flipped from ER+ to TN after liver progression and biopsy. Or so we thought. One small lesion (sub-centimeter) on my spine went crazy the following month and we eventually found out it had stayed ER+. Just another example of the unexpected. Good luck to yourwife

Dx 1/23/2019, DCIS/IDC, Left, 3cm, Stage IV, metastasized to liver, Grade 2, ER+/PR-, HER2- Hormonal Therapy 1/23/2019 Femara (letrozole) Targeted Therapy 1/24/2019 Ibrance (palbociclib) Surgery 12/3/2019 Lumpectomy; Lumpectomy (Left) Surgery 12/3/2019 Lymph node removal Radiation Therapy 3/17/2020 Whole breast Dx IDC/DCIS, ER-/PR-, HER2-
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May 11, 2022 03:52AM ap3 wrote:

I found a study that says 25% of TNBC can become ER+: https://pubmed.ncbi.nlm.nih.gov/25454687/ (albeit after NCT)

I think it's definitely worth getting any new lesions biopsied if at all possible!

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Jun 8, 2022 06:17AM moderators wrote:

Hi all! Exciting news out of ASCO we thought you might be interested in:

A New Standard of Care? Enhertu Improves Survival in People With Metastatic HER2-Low Breast Cancer
June 6, 2022

Compared with doctors' choice of chemotherapy, Enhertu (chemical name: fam-trastuzumab-deruxtecan-nxki) improved both progression-free survival and overall survival in people diagnosed with previously treated metastatic HER2-low breast cancer. Read more...

To send a PM to the Mods: community.breastcancer.org/my/...
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Jun 8, 2022 07:00AM nicolerod wrote:

Sorry mods..but i am confused why this is posted here...Her2low is not HER2- 0%..which is what most if not all TNBC are...

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 Cryoblation on 2 of 4 tumors in liver. Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy; Mastectomy (Left); Mastectomy (Right)
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Jun 8, 2022 08:02AM moderators wrote:

From the article: "About 15% to 20% of breast cancers are HER2-positive. Still, research shows that more than 60% of breast cancers considered HER2-negative have some HER2 proteins on the surface of its cells. There just aren't enough HER2 proteins for the cancer to be considered HER2-positive. Doctors now call these cancers HER2-low."
So, some members here may be treated or think they are HER2-negative but may actually be HER2-low, in which case this study could be beneficial to them.

Hope this helsp!

The Mods

To send a PM to the Mods: community.breastcancer.org/my/...

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