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May 10, 2021 04:52PM
May 10, 2021 04:53PM
candy, take this with a grain of salt because I am no expert, but this is basically what my MO said after I had a similar situation:
We do lose some of our ER+ receptors after being heavily treated, and while that does not make us "triple negative" it can mean that hormone therapy might be less effective, but not necessarily. PR positivity depends somehow, or is connected to ER positivity. My last metastatic biopsy specimen was ER negative - fully 0% estrogen receptors - but I still had 70-80% PR positivity. My MO said this means my cancer is still somehow hormone and estrogen driven. The catch though, is that for me hormone medicines and Ibrance have stopped working, so I am back on iv chemo for the time being. So even though I am not triple negative, we are kind of treating me like I am, at least for now. Chemo did clear out the lesions in my liver, for the most part, so that was a win for now. The cancer in and around my lungs is being stubborn though.
What do I make of all that? I really don't know. As long as my MO understands it I'm happy with that, but I am progressing in a couple areas so I may ask for a fresh biopsy and see if anything has changed again. Best wishes to you!
Diagnosed at 32. Local recurrences one year later, probably due to needle seeding at inital biopsy. Now dealing with MBC.
8/2016, IDC, Right, Stage IA, Grade 3, 0/2 nodes, ER+/PR+, HER2-
10/1/2016 Lumpectomy: Right; Lymph node removal: Sentinel
11/1/2016 Cytoxan (cyclophosphamide), Taxotere (docetaxel)
4/1/2017 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone)
10/2017, IDC, Right, Grade 3, 2/12 nodes, ER+/PR+, HER2-
11/1/2017 Lymph node removal; Mastectomy: Right
3/31/2018 Lymph node removal; Mastectomy: Right
4/30/2018 External: Lymph nodes, Chest wall
6/30/2018 Xeloda (capecitabine)
7/30/2018 Zoladex (goserelin)
2/1/2019 Aromasin (exemestane)
9/30/2019 Faslodex (fulvestrant)
8/2020, IDC, Stage IV, metastasized to bone/other, Grade 3, ER+/PR+, HER2-
8/30/2020 Ibrance (palbociclib)
1/2021, IDC, Stage IV, metastasized to liver/lungs
1/15/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine)