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Topic: How are people with liver mets doing?

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

Posted on: Aug 16, 2013 07:02PM

blondie1 wrote:

I continue to be very scared once I found my liver mets progressed after having to go off doxil. I am hoping to find some support in alleviating my deep seated fears by hearing other stories of people living and dealing with liver mets. My onc says I have such a petite frame (105) that an enlarged liver will definitely cause me some pain until chemo takes care of it.

How are others doing and getting through this with a positive attitude?

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Nov 20, 2021 05:37PM leftfootforward wrote:

Nicole- I’d go with your gut feeling no pun intended.

If it were me, I’d do either 1 or 2 but probably 1 for a few more cycles. If my pain continued while staying with 1- is move to. #2.

Your PET results sound stable. I’d be happy with those results even if they aren’t 100% clear.

Dx 12/13/2010, IDC, 3cm, Stage IIIA, Grade 2, 1/16 nodes, ER-/PR-, HER2+ Dx 12/4/2012, IDC, Stage IV, 0/0 nodes, ER-/PR-, HER2+
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Nov 20, 2021 05:41PM leftfootforward wrote:

having seen the photo with what we deal with living with metastatic cancer. I wanted to ask you- what are you doing for dry mouth and very dry eyes?

I have had multiple eye appointments to try and deal with my dry eyes. Nothing has helped. Do I am scheduled for a much more rigorous work up to see how to best deal with them. Obviously, I am not gooo g to change my cancer treatment.

Have any of you found a solution that works for you? mas far as dry mouth, I just find myself drinking more. Water.

Thanks in advanc

Dx 12/13/2010, IDC, 3cm, Stage IIIA, Grade 2, 1/16 nodes, ER-/PR-, HER2+ Dx 12/4/2012, IDC, Stage IV, 0/0 nodes, ER-/PR-, HER2+
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Nov 20, 2021 06:55PM Teedoff wrote:

lFF: Water is super important. I also use Systane drops. Each application is individually packaged and very soothing. Doesn't contain preservatives. Won't break the bank either. I suck on Spry tabs from time to time during the day. Minty like Tic Tacs and contain Zylitol. Not long lasting relief, but not much is. Worth trying if you haven't already.

Teedoff Dx 1/2011, IDC, Left, Grade 2, ER+/PR+, HER2- Dx 10/2015, IDC, Left, Stage IV, metastasized to bone/liver Chemotherapy Xeloda (capecitabine) Hormonal Therapy Aromasin (exemestane) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Arimidex (anastrozole) Chemotherapy AC + T (Taxol) Chemotherapy Taxol (paclitaxel)
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Nov 20, 2021 08:07PM - edited Nov 20, 2021 08:10PM by ShetlandPony

LFF, it sounds like you are seeing an ophthalmologist? That's good, so you can get to the reason(s) for your eye trouble. My ophthalmologist determined I had a combination of dryness and inflammation. No doubt cancer meds and lack of collagen (from anti-estrogens) to keep my lower lids tight play a role. Ultimately, Restatsis drops have been the best help for me. Here is a rundown of the ophthalmologist's suggestions:

--Fish oil capsules. I found a brand called Nordic Naturals that tests low for heavy metals (can be problem with fish in general). Obviously ok this supplement with your onc.

--Lubricating eye drops, as often as needed. Systane Ultra, Refresh Optive. Get the single-use vials that are preservative-free if you are going to use these long-term. The last thing we need is irritation from the preservative. Can use ointment overnight.

--Punctal plugs. He put a small plug in the inner tear duct to keep the tears in my eyes longer so they could do their job.

--Temporary steroid eye drops to calm down the inflammation that made my eyes feel so irritated. You can't use these long term, but they are great for occasional use.

--Prescription Restatsis which treats both the inflammation and the dryness. This is what I use now and it has worked the best for me. My eyes still tear, but they are not tearing so constantly any more.


For dry mouth, Biotene gentle mint moisturizing mouth rinse might help.

2011 Stage I ITCs sn, premenopausal, Oncotype 16. 2014 Stage IV mets breast,liver. TaxolNEAD. Ibrance+letrozole 2yrs. Fas+afinitor nope. XelodaNEAD 2yrs. Eribulin,Doxil nope. SUMMIT FaslodexHerceptinNeratinib for Her2mut NEAD 1 1/2yrs. GI/perit mets Dx 2011, ILC, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Dx 2014, ILC, 2cm, Stage IV, metastasized to liver/other, Grade 2, ER+/PR+, HER2- Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole-breast: Breast Surgery Lumpectomy
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Nov 21, 2021 07:44AM Kattysmith wrote:

SP, what ointment are you talking about that you apply overnight? The only advise my new very young ophthalmologist suggested was using my Refresh Optive drops right before bedtime. Most mornings I have to pry my eyelids open.

What's more disturbing is that she discovered hyperpigmentation in both of my retinas, so I'm having a retinal scan on the 29th. My vision had really been deteriorating in one eye. I have to admit that I am scared as shit about this. After I find out from the opthamologist exactly what's going on, I'll discuss it with my MO on the 3rd.


First diagnosed borderline Stage 2 IDC, left breast in 2003. No problems until a surprise (!) Stage IV recurrence in 2015! In addition to treatments listed below, I started monthly injections of Xgeva for bone support in July 2016. Dx 10/23/2015, Left, Stage IV, metastasized to other, Grade 3, 0/3 nodes, ER+, HER2- Chemotherapy 11/3/2015 AC Hormonal Therapy 2/4/2016 Femara (letrozole) Targeted Therapy 2/4/2016 Ibrance (palbociclib) Immunotherapy 12/22/2018 Hormonal Therapy Faslodex (fulvestrant)
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Nov 21, 2021 09:02AM candy-678 wrote:

On the dry eye and dry mouth conversation---

I have an autoimmune disorder called Sjogrens Syndrome. Diagnosed by a rheumatologist. My eye doctor prescribes me Restasis eye drops (used twice a day 12 hours apart) and I use Systane eye drops (over the counter) as many times a day as I need. I also use an eye ointment every night as I want my eyes lubricated during sleep as I have had corneal abrasions in the past. So I use over the counter Muro 128 eye ointment at night- get at my pharmacy but no prescription needed.

I have more problems with my eyes than my mouth, but my rheumatologist recommended Biotene over the counter mouth products.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Xgeva use for bone mets. Liver bx Apr 2021 shows ER- now. Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Surgery 7/11/2017 Lymph node removal: Sentinel; Mastectomy: Left Chemotherapy 7/31/2017 AC Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Femara (letrozole), Zoladex (goserelin) Dx 4/2021, ILC/IDC, Stage IV, metastasized to bone/liver, ER-/PR+, HER2- (FISH) Targeted Therapy 9/3/2021 Lynparza Hormonal Therapy 9/4/2021 Zoladex (goserelin)
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Nov 22, 2021 02:17AM - edited Nov 22, 2021 07:31AM by BSandra

Dear Dee, super good news on the trial!

Dear Nicole, your scan seems really good - things are under control, and that is amazing. I'd ask your MO what she thinks next therapy would be but re-scanning in 2 months is a good idea with whatever choice. I personally think your goal is to shrink things, so maybe new therapy is a good idea?

Everyone: intriguing results from #DAISY ph2 trial: tested T-DXd for ABC with ANY HER2 expression. Response rate among tumors scored IHC 0 was.. 30%! An idea of bispecific antibody with TROP2/HER2 blockade comes into my mind!

Saulius

Since May'21:NED. Mar'21:axilla LN surgery. Sep'19-Mar'21:NED. Feb'19:recurrence, left breast,IBC. May'18-Feb'19:NED. Jun'18:DC/CIK. Aug'17:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal: Underarm/Axillary Radiation Therapy 12/13/2021 3DCRT: Lymph nodes
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Nov 22, 2021 03:06AM BSandra wrote:

Dear Nicole and others, another good IO option for mTNBC: https://www.targetedonc.com/view/triplet-therapy-s...

Entinostat+Nivolumab(Opdivo)+Ipilimumab(Yervoy)

Since May'21:NED. Mar'21:axilla LN surgery. Sep'19-Mar'21:NED. Feb'19:recurrence, left breast,IBC. May'18-Feb'19:NED. Jun'18:DC/CIK. Aug'17:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal: Underarm/Axillary Radiation Therapy 12/13/2021 3DCRT: Lymph nodes
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Nov 22, 2021 07:22AM terri-c wrote:

Nicole, I'm relieved the scan results were pretty good. I know the pain is disconcerting, but it could be just still dealing with mild inflammation from the Y90 and the chemo. I think you got some good advice here, and I would hold off making any decisions until you get the MRI results. A better look can usually provide some clarity.

Dx 7/7/2011, IDC, <1cm, Stage I, Grade 1, 0/9 nodes, ER+/PR+, HER2- Dx 4/7/2014, IDC, Right, <1cm, Stage IV, metastasized to bone/liver/lungs/other, Grade 2, 0/9 nodes, mets, ER+/PR+, HER2-
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Nov 22, 2021 02:22PM - edited Nov 22, 2021 02:43PM by NicoleRod

Hi all......I talked to my MO today...we are going to stay on the 50% dose of Halaven for now....and scan sooner 2 months mid January...if I have more pain or bilirubin keeps rising then we will talk sooner and possibly switch treatment. I am fairly postitive next treatment will be Trodlevy which we discussed today. I cannot do a PARP inhibitor of my CHEK2 mutation as they are ONLY approved for BRCA positive...they are TRYING them in trials for CHEK2 but nothing is set that they are even being really effective in that. I am letting go of the Keytruda idea for now..simply bc I am no longer PDL1 positive but now ...negative and Keytruda can cause its own set of side effects including making my Esphogitis even worse.... My MO knows I have the MRI Monday (a week from today) so I guess we will know more then....I have to bring the disc to my IR in Washington DC to read too...so until that is all done I will be getting the Eribulin/Halaven I have been on.

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 22, 2021 03:39PM Husband11 wrote:

Sounds like a reasonable plan Nicole. How high is your bilirubin? Isn't high bilirubin a sign of a physical obstruction to a duct? Are there signs of that?

Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Nov 22, 2021 03:50PM NicoleRod wrote:

Husband...I havent had it checked in 2 weeks but last time it was now 1.2...but it has been rising every week from 0.7 to 1.2 and now we will see tomorrow at chemo what it is. I don't believe I have any duct obstruction bc I think they would have saw that on the scan and I don't have that kind of pain...my pain is down where my Y90 was...

Your wife and most have tumor markers to go by...but for me...its bilirubin and my itchy bites... lol

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 22, 2021 04:19PM Husband11 wrote:

Well, you know your body. As always you are in my prayers.

Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Nov 22, 2021 04:44PM NicoleRod wrote:

Thanks Husband!!

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 23, 2021 09:19AM candy-678 wrote:

So yesterday was a long day with scans, bloods, and MO. Pretty good news. I cannot see my scan results yet in the portal (checked again this morning) but MO said there was a decrease in the size of the liver mets. She said "small decreases" but decreases all the same. When I can see the report myself I can compare the sizes from last time to this time and see just how much the decreases were. She asked again if I thought about the Y90 procedure. I said if the Lynparza was working then I want to continue that for now.

There was an interesting finding. Multiple lung nodules in the right lung. MO not convinced it is cancer. Doing another CT in 8 weeks to monitor. I am trying not to get anxious. Could be something other than cancer. But I have not been sick-- no fever, no cough, no illness of any kind. So.... who knows.

My WBC were at the best in 4 years !!!! WBC 3.1-- still low, but much better than usual. ANC was 2200 (2.2) !!!! Wow !!! So the Lynparza is not hitting the white counts as bad as the Ibrance did. Hemoglobin was stable at 9.6--- low but stable.

So overall a good report.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Xgeva use for bone mets. Liver bx Apr 2021 shows ER- now. Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Surgery 7/11/2017 Lymph node removal: Sentinel; Mastectomy: Left Chemotherapy 7/31/2017 AC Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Femara (letrozole), Zoladex (goserelin) Dx 4/2021, ILC/IDC, Stage IV, metastasized to bone/liver, ER-/PR+, HER2- (FISH) Targeted Therapy 9/3/2021 Lynparza Hormonal Therapy 9/4/2021 Zoladex (goserelin)
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Nov 23, 2021 10:33AM SusaninSF wrote:

Woo hoo!!! Great news, Candy!

Are you BRCA positive?

Hugs, Susan

Mets to brain, lung, liver, eye, femur bone. 1/6/22 started on ARX788 trial. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy: Left, Right; Lymph node removal: Right, Sentinel; Reconstruction (right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy: Right Dx 3/29/2014, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External: Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External: Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External: Brain Immunotherapy 10/25/2019 Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Hormonal Therapy 3/12/2021 Aromasin (exemestane) Targeted Therapy 3/16/2021 Verzenio Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Radiation Therapy 12/21/2021 External: Bone Targeted Therapy 1/6/2022
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Nov 23, 2021 10:38AM denny10 wrote:

hi candy-678, i think that report should be celebrated in a way you think is best, congratulations!

12/2021 Stage IV TN Dx 2007, Left, Stage IIB Dx 12/2013, Right, Stage IV, metastasized to liver/lungs/other, ER+
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Nov 23, 2021 11:21AM candy-678 wrote:

SusaninSF- Yes I am BRCA positive.

Found mets on CT for unrelated issue. I only had 2 treatments with IV chemo for the Stage II, then found Stage 4 and switched to hormone therapy/targeted therapy. I consider myself de novo. Xgeva use for bone mets. Liver bx Apr 2021 shows ER- now. Dx 6/2017, ILC/IDC, Left, 3cm, Stage IIB, Grade 3, 0/1 nodes, ER+/PR+, HER2- Surgery 7/11/2017 Lymph node removal: Sentinel; Mastectomy: Left Chemotherapy 7/31/2017 AC Dx 9/2017, ILC/IDC, Stage IV, metastasized to bone/liver, 0/1 nodes, ER+/PR+, HER2- Targeted Therapy 11/1/2017 Ibrance (palbociclib) Hormonal Therapy 11/1/2017 Femara (letrozole), Zoladex (goserelin) Dx 4/2021, ILC/IDC, Stage IV, metastasized to bone/liver, ER-/PR+, HER2- (FISH) Targeted Therapy 9/3/2021 Lynparza Hormonal Therapy 9/4/2021 Zoladex (goserelin)
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Nov 23, 2021 12:49PM moth wrote:

candy - congrats on the scan. Seems like lynparza is really working well for you!

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External: Chest wall Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/3/2021 External: Bone
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Nov 23, 2021 01:17PM B-A-P wrote:

yay Candy ! That’s excellent! I’m BRCA positive as well. I wonder if I’d be able to avail of this if ibrance doesn’t work for me/I continue to have low counts with it.

Dx 8/17/2018, IDC, Left, Stage IV, metastasized to liver, ER+/PR+, HER2- (FISH) Chemotherapy 9/17/2018 Cytoxan (cyclophosphamide), Ellence (epirubicin), Fluorouracil (5-fluorouracil, 5-FU, Adrucil) Surgery 2/26/2019 Mastectomy: Left, Right Radiation Therapy 4/28/2019 Whole-breast: Breast, Lymph nodes, Chest wall Targeted Therapy 10/7/2021 Ibrance (palbociclib) Dx IDC, Stage IV, metastasized to liver, ER+/PR-, HER2- (FISH) Hormonal Therapy Femara (letrozole) Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Prophylactic ovary removal Chemotherapy Abraxane (albumin-bound or nab-paclitaxel) Hormonal Therapy Faslodex (fulvestrant)
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Nov 23, 2021 01:21PM NicoleRod wrote:

Dee so sorry that the report is so indecisive . I hate feeling like that.

Candy SOOO HAPPY for you..

So i had chemo today and guess what...YUP bilirubin on the rise again....1.7 now... started at 0.7. So she doesn't think its the Ivermectin...bc (I was right) if it was the ALT and AST would be elevated ...those usually go up with new meds or supplements. So that leaves 1 of 3 things... well to her 1 of 2...

1. Blockage (which we will know on Monday i have MRI

2. Progression...

or I think possibly Inflammation.....but she only mentioned back those top 2 when I asked about all 3.....

I am getting a little concerned bc if it is a blockage that is SOOOO SCARY and would require a procedure/surgery... and also if its inflammation this far out from the Y90 (it was done in June)...then could I be heading toward liver failure??? :(.


Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 23, 2021 03:23PM - edited Nov 23, 2021 03:24PM by Husband11

Nicole, I understand that problems with the gallbladder can also cause elevated bilirubin levels. Will they image that on the MRI? A formation of a gallstone might be a cause.

A layman like me would think that if it was imflammation of the liver, the ALT and other liver enzymes would rise as well.

Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Nov 23, 2021 03:57PM NicoleRod wrote:

Husband thanks for the input bc I was wondering if other things would rise if it was from inflammation. I did tell my MO that when I take the ivermectin I dilute it in 8ml of vodka it makes the med over 80% more bioavailable...but that is a minute amount and she didn't seem concerned at all...I also take it with grapefruit juice. ..... I just now that my pain is LOW...down toward the bottom rib, again..exactly where the Y90 was...and it only hurts when I take a deep breath...like when my body expands..(the liver into the ribs) if you understand what I mean...if I am just sitting no pain...walking no pain only when take a deep breath which makes me think its that the liver is inflammed...or like swollen? I don't even know if that is possible...but yea. the MRI is of Abdomen...so I think they get the gallblader....

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 23, 2021 05:27PM Sadiesservant wrote:

Nicole, is Eribulin okay with grapefruit juice? I avoid it completely, although I love grapefruit as it interacts with so many cancer meds. Just flagging...

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/10/2001 Lumpectomy: Right; Lymph node removal: Right, Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole-breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/28/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/20/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External: Bone Hormonal Therapy 1/18/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External: Bone Radiation Therapy 11/5/2018 External: Bone Targeted Therapy 10/9/2019 Verzenio Radiation Therapy 11/3/2020 External: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Navelbine (vinorelbine) Chemotherapy 1/7/2022 Halaven (eribulin)
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Nov 23, 2021 06:13PM NicoleRod wrote:

Sadie I don't know...but I am positive now that the elevation in Bilirubin is from the Tumor that didn't get killed completely in the Y90 in June. Otherwise all my other numbers would be elevated as well. I only take 3oz of grapefruit juice 1 time on Mon , Tuesday and Wed....

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 23, 2021 07:15PM Sadiesservant wrote:

You might want to check in with your MO or the pharmacy. It's only a small amount but grapefruit is typically on the forbidden list for most chemotherapies.

Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of intestinal CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/10/2001 Lumpectomy: Right; Lymph node removal: Right, Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole-breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/28/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/20/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External: Bone Hormonal Therapy 1/18/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External: Bone Radiation Therapy 11/5/2018 External: Bone Targeted Therapy 10/9/2019 Verzenio Radiation Therapy 11/3/2020 External: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Navelbine (vinorelbine) Chemotherapy 1/7/2022 Halaven (eribulin)
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Nov 23, 2021 07:56PM SusaninSF wrote:

I also avoid grapefruit juice. Any other juices seem to be fine.

Mets to brain, lung, liver, eye, femur bone. 1/6/22 started on ARX788 trial. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy: Left, Right; Lymph node removal: Right, Sentinel; Reconstruction (right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy: Right Dx 3/29/2014, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External: Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External: Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External: Brain Immunotherapy 10/25/2019 Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Hormonal Therapy 3/12/2021 Aromasin (exemestane) Targeted Therapy 3/16/2021 Verzenio Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Radiation Therapy 12/21/2021 External: Bone Targeted Therapy 1/6/2022
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Nov 23, 2021 08:31PM Sadiesservant wrote:

Pomegranate can be an issue as well but with fewer drugs. I can’t recall but think I was advised to avoid pomegranate when I was on Ibrance… I think.

Dx 4/2001, IDC, Right, 1cm, Stage IIA, Grade 3, 1/10 nodes, ER+ Surgery 5/10/2001 Lumpectomy: Right; Lymph node removal: Right, Sentinel, Underarm/Axillary Chemotherapy 6/7/2001 CEF Radiation Therapy 12/17/2001 Whole-breast: Breast Hormonal Therapy 12/20/2001 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Hormonal Therapy 1/2/2007 Femara (letrozole) Hormonal Therapy 10/22/2007 Arimidex (anastrozole) Dx 1/3/2017, IDC, Right, Stage IV, metastasized to bone/lungs, ER+/PR+, HER2- Chemotherapy 1/27/2017 Taxol (paclitaxel) Hormonal Therapy 3/28/2017 Arimidex (anastrozole) Targeted Therapy 4/20/2017 Ibrance (palbociclib) Dx 10/12/2017, IDC, Right, Stage IV, metastasized to other Chemotherapy 10/20/2017 Xeloda (capecitabine) Radiation Therapy 11/15/2017 External: Bone Hormonal Therapy 1/18/2018 Faslodex (fulvestrant) Radiation Therapy 8/2/2018 External: Bone Radiation Therapy 11/5/2018 External: Bone Targeted Therapy 10/9/2019 Verzenio Radiation Therapy 11/3/2020 External: Bone Dx 1/22/2021, IDC, Right, 1cm, Stage IV, metastasized to liver, Grade 2, ER+/PR+, HER2- Chemotherapy 2/4/2021 Xeloda (capecitabine) Chemotherapy 10/8/2021 Navelbine (vinorelbine) Chemotherapy 1/7/2022 Halaven (eribulin)
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Nov 25, 2021 01:11AM BSandra wrote:

Dear Dee, what happened with the post? Dear BAP, how are you? Nicole, Shetland?

Saulius

Since May'21:NED. Mar'21:axilla LN surgery. Sep'19-Mar'21:NED. Feb'19:recurrence, left breast,IBC. May'18-Feb'19:NED. Jun'18:DC/CIK. Aug'17:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal: Underarm/Axillary Radiation Therapy 12/13/2021 3DCRT: Lymph nodes
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Nov 25, 2021 01:23AM - edited Nov 25, 2021 01:24AM by ShetlandPony

While my October scans showed no active liver mets, and the bile duct is working fine with no stents, the CT showed a narrowing of the transverse colon, that was biopsied via colonoscopy and shown to be caused by an ILC met. I had quickly developed symptoms of a pretty bad blockage, and am now recovering from abdominal surgery to remove the section with the tumor. But the surgeon noted "multiple peritoneal nodules along the peritoneal surfaces, bowel mesentery and on the intestines" so I need a good systemic treatment once I have recovered enough. Treatment is on hold right now except for Faslodex. Hoping genomic sequencing will be done next week and my onc and I can form a treatment plan.

Saulius, the mods said elsewhere that Dee's account was compromised, thus the deletions of posts that were not actually hers.

2011 Stage I ITCs sn, premenopausal, Oncotype 16. 2014 Stage IV mets breast,liver. TaxolNEAD. Ibrance+letrozole 2yrs. Fas+afinitor nope. XelodaNEAD 2yrs. Eribulin,Doxil nope. SUMMIT FaslodexHerceptinNeratinib for Her2mut NEAD 1 1/2yrs. GI/perit mets Dx 2011, ILC, 1cm, Stage IA, Grade 1, 0/1 nodes, ER+/PR+, HER2- Dx 2014, ILC, 2cm, Stage IV, metastasized to liver/other, Grade 2, ER+/PR+, HER2- Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy Whole-breast: Breast Surgery Lumpectomy

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