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Topic: Are you currently (or have you been) in a Clinical Trial?

Forum: Stage IV/Metastatic Breast Cancer ONLY —

Please respect that this forum is for members with stage IV/metastatic breast cancer only. There is a separate forum for caregivers and friends: Caring for Someone with Stage 4 or Mets.

Posted on: Nov 29, 2018 04:40AM

Kattysmith wrote:

I am about to start a clinical trial and am wondering about the experiences of others. I'm feeling a little rocky and at sea, because I've been in the care of a wonderful oncologist for the past three years, and I knew without a doubt that his prime objective was the same as mine - to keep me stable and maintain a good quality of life. It was all about me.

Now, I'm embarking on this trial on a different campus and with a different doctor. I really like the doctor who heads it (he is a close colleague of my oncologist and has conferred with him), but I not-so-secretly worry that the prime focus will not be on my well-being, that it will be secondary to the study objectives. My initial meeting with the CO pretty much dispelled my fear that I would be a lab rat, but the closer I get to starting, the more leery I get. I'm normally not anxious about treatments.

I haven't had any treatment at all for several weeks, because the last treatment was ineffective and my onc wanted to get me into a trial, so the waiting hasn't helped. I'm normally pretty chill about everything, including starting new treatments, but entering a clinical trial is a different kettle of fish.

What has been your experience? Have you felt cared for?

First diagnosed borderline Stage 2 IDC, left breast in 2003. No problems until a surprise (!) Stage IV recurrence in 2015! In addition to treatments listed below, I started monthly injections of Xgeva for bone support in July 2016. Dx 10/23/2015, Left, Stage IV, metastasized to other, Grade 3, 0/3 nodes, ER+, HER2- Chemotherapy 11/3/2015 AC Hormonal Therapy 2/4/2016 Femara (letrozole) Targeted Therapy 2/4/2016 Ibrance (palbociclib) Immunotherapy 12/22/2018 Hormonal Therapy Faslodex (fulvestrant)
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Nov 10, 2021 04:10PM - edited Nov 10, 2021 04:14PM by SusaninSF

Thanks for sharing that info, Cure-ious. Hopefully they will start things in early 2022. Perhaps some of us will qualify for phase 1b.

AlabamaDee, This is great news and I hope you can get on the trial!

Hugs, Susan

Mets to brain, lung, liver, eye, femur bone. 1/6/22 started on ARX788 trial. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy: Left, Right; Lymph node removal: Right, Sentinel; Reconstruction (right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy: Right Dx 3/29/2014, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External: Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External: Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External: Brain Immunotherapy 10/25/2019 Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Hormonal Therapy 3/12/2021 Aromasin (exemestane) Targeted Therapy 3/16/2021 Verzenio Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Radiation Therapy 12/21/2021 External: Bone Targeted Therapy 1/6/2022
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Nov 11, 2021 04:16AM Kattysmith wrote:

Alabama Dee, I'm so relieved that you may have a new trial option and am keeping my fingers crossed and sending good vibes your way!

Susan, I am in awe of how you nurture your well being! I have been way too passive and self-indulgent in this area with the predictable results. You are an inspiration.

First diagnosed borderline Stage 2 IDC, left breast in 2003. No problems until a surprise (!) Stage IV recurrence in 2015! In addition to treatments listed below, I started monthly injections of Xgeva for bone support in July 2016. Dx 10/23/2015, Left, Stage IV, metastasized to other, Grade 3, 0/3 nodes, ER+, HER2- Chemotherapy 11/3/2015 AC Hormonal Therapy 2/4/2016 Femara (letrozole) Targeted Therapy 2/4/2016 Ibrance (palbociclib) Immunotherapy 12/22/2018 Hormonal Therapy Faslodex (fulvestrant)
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Nov 12, 2021 08:28AM - edited Nov 12, 2021 08:29AM by SusaninSF

Anyone know anything about samuraciclib (CT7001)? There is a Phase I/II trial (https://www.clinicaltrials.gov/ct2/show/NCT03363893) for ER+HER2- patients that is no longer recruiting. The FDA has fast-tracked this drug and the company is presenting at the SABC conference in December.

Mets to brain, lung, liver, eye, femur bone. 1/6/22 started on ARX788 trial. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy: Left, Right; Lymph node removal: Right, Sentinel; Reconstruction (right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy: Right Dx 3/29/2014, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External: Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External: Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External: Brain Immunotherapy 10/25/2019 Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Hormonal Therapy 3/12/2021 Aromasin (exemestane) Targeted Therapy 3/16/2021 Verzenio Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Radiation Therapy 12/21/2021 External: Bone Targeted Therapy 1/6/2022
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Nov 12, 2021 11:05AM - edited Nov 12, 2021 11:07AM by Cure-ious

Hi Susan, Yes, CT7001 is an oral CDK7 inhibitor, we have been talking about that drug for ages.. One problem was that the pharmas started out testing IV versions then had to start over with oral versions because the IV wasn't going to be competitive, and another problem is they were in the hands of start ups, which can be slow to market

Anyway, CDK7 was first identified as a target for triple-negative breast cancers, with a paper in Cell in 2015 showing that those cancers are "addicted" to CDK7

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45836...

And then later it was found to also work for ER-positive MBCs, and there it was associated with progression on I-F, such that inhibiting CDK7 could make the resistant cancers become estrogen-dependent again. https://pubmed.ncbi.nlm.nih.gov/32340192/

As with everything, we are waiting to hear how good is the drug, how bad are the SEs, and what kind of combinations work best etc, very glad to finally see this drug move along!!!

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Nov 12, 2021 12:42PM Bestbird wrote:

SusaninSF, Samuraciclib appears at this juncture to be a promising drug.

Below is an excerpt about it from my book, The Insider's Guide to Metastatic Breast Cancer." The Insider's Guide to Metastatic Breast Cancer: A Summary of the Disease and its Treatments: Loeser, Anne: 9781795860604: Amazon.com: Books

Samuraciclib (CT-7001) (Not Yet FDA-Approved for MBC Patients): Samuraciclib is an oral CDK7 inhibitor that showed encouraging results in a Phase 2 study in combination with fulvestrant in patients with advanced HR+, HER2- BC. 31 patients were with difficult-to-treat disease were enrolled; 81% had visceral disease, including 45% with liver metastasis. All patients previously progressed following treatment with a CDK4/6 inhibitor. Of the 31 patients, 24 were evaluable for response at the time of data cut-off. 17 (71%) had tumor shrinkage, and median Progression Free Survival (PFS) was 16.1 weeks. Notably, patients with no mutation in the TP53 gene had a median PFS of 32.0 weeks. Prolonged disease control was also apparent in patients with no liver metastases at baseline, with median PFS having not yet been reached (at the point of this data cut-off, median PFS would be at least 28 weeks). From: https://www.biospace.com/article/releases/carrick-therapeutics-presents-encouraging-initial-efficacy-for-samuraciclib-ct-7001-in-combination-with-fulvestrant-in-advanced-hr-her2-breast-cancer-patients-at-esmo-congress-2021/



Dx 10/6/2011, IDC, Left, Stage IV, ER+/PR+, HER2-
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Nov 12, 2021 01:23PM Husband11 wrote:

More on Samuraciclib: Safety and Antitumour Activity of a First-in-Class, Oral (esmo.org)


Concerned husband Dx 2008, Left, Stage IIIB, Grade 3, 7/14 nodes, ER+/PR+, HER2- Dx 5/2016, Stage IV, metastasized to liver, ER+/PR+, HER2- Chemotherapy Xeloda (capecitabine) Targeted Therapy Ibrance (palbociclib) Chemotherapy Hormonal Therapy Femara (letrozole)
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Nov 13, 2021 07:24PM - edited Nov 13, 2021 07:27PM by Cure-ious

Here are some interesting results from a phase 2 trial looking at Keytruda in combination with Imprime PGG (an activator of the innate immune system that reprograms the suppressive immune environment around the tumor). Consistent with earlier findings that those individuals whose cancer subtype switched from ER-positive to ER-negative are more sensitive to immunotherapy, this trial came to the same conclusion:

"Researchers observed a particularly pronounced clinical benefit in a subgroup of patients who initially were diagnosed with ER-positive/PR-positive disease but progressed on endocrine therapy and, prior to treatment, had biopsies that confirmed conversion to triple-negative breast cancer..."

The IMPRIME1 trial included 44 patients, 27% had liver mets. Overall, they found that 27% responded (ie, tumor shrinkage or stable disease) for at least six months.

"Investigators observed pronounced clinical benefit with the combination among a subgroup of 12 patients originally diagnosed with ER-positive/PR-positive disease who underwent prior treatment with endocrine therapy and later converted to triple-negative disease."

In this group, six (50%) achieved response (tumor shrinkage) to the combination, four (33%) achieved stable disease, and six (50%) achieved disease control for 6 months.

In a subsequent publication, they reported: Ten IMPRIME 1 patients were originally ER/PR+, received hormonal Tx and progressed to TNBC. Of these, 5 are confirmed PR (tumor shrinkage), 4 SD (stable disease, 3 are still on treatment), and one had progressive disease. https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.1...

Adding Imprime IGG almost doubled the overall survival compared to Keytruda alone. This trial ended in March, and in January the company announced they had developed an assay for an immune biomarker that is necessary for patients to respond to the Imprime IGG treatment.

https://www.healio.com/news/hematology-oncology/20...

https://finance.yahoo.com/news/hibercell-biodesix-...



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Nov 14, 2021 04:41AM NicoleRod wrote:

WOW that sounds promising for me Cure! Too bad only Phase 2... :(

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 14, 2021 09:24AM Grannax2 wrote:

I have some news. Mary Crowley found a new trial for me. Yay.

On Friday I went for the consent/ screening appointment and scans, etc. one step closer to being accepted. I signed my life away. LOL But, as I understand it, I can still possibly be disqualified depending on the results?!?! Even some of my medications may have to be changed.

It’s called MCMRC IRB #21-20 and ImmVira Ph 1/2 T3011. I will be on the study agent only. Some people will also be on Keytruda.

Basically, they use HSV ( modified) infusions to try and activate my immune system to kill the cancer. Cure ious I’m sure I don’t have the expertise you have to explain this trial.

The schedule doesn’t seem to be as time consuming as the other trials I looked at. I only have to spend two eight hour days at the center each week. Plus, one

lab only appointment each week.

Next week I will have a liver BX and a Brain MRI. My tentative start date is November 29.

Now, for the waiting. UGH to see if I qualify.

If anyone knows more information about this trial, I’d love to hear it.

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Nov 14, 2021 09:25AM NicoleRod wrote:

Grannax thats great!


Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 14, 2021 09:40AM SusaninSF wrote:

Grannax,

Fantastic news! So wonderful that Mary Crowley is doing the searching for you,

I am still waiting to hear from USC about the ARX-788 trial. In the meantime, trying to stay positive and keep my body in the best shape I can.

Hugs, Susan

Mets to brain, lung, liver, eye, femur bone. 1/6/22 started on ARX788 trial. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy: Left, Right; Lymph node removal: Right, Sentinel; Reconstruction (right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy: Right Dx 3/29/2014, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External: Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External: Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External: Brain Immunotherapy 10/25/2019 Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Hormonal Therapy 3/12/2021 Aromasin (exemestane) Targeted Therapy 3/16/2021 Verzenio Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Radiation Therapy 12/21/2021 External: Bone Targeted Therapy 1/6/2022
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Nov 14, 2021 11:05AM Grannax2 wrote:

Thanks, Susan. The waiting is so hard. Sure hope you get in.

Thanks, Nicole. I know you’re exploring options. I hope you find the best fit for you.

I’m very glad to have friends here to encourage us

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Nov 14, 2021 01:28PM - edited Nov 14, 2021 01:28PM by Cure-ious

Susan,

Regarding ARX788, which is an ADC that combines a HER2-directed monoclonal antibody with a new drug (Amberstatin269), they had great results in phase 1. The overall response rate (ORR) was 74% for HER2-positive breast cancer, and 67% in patients with HER2-overexpressing solid tumors (ORR refers to number of people who got tumor shrinkage). Across both populations, the disease control rate (meaning shrinkage or stable for six months) was 100%.

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Nov 14, 2021 03:20PM SusaninSF wrote:

Thanks, Cure-ious. Those are some impressive stats.

I am SO HOPEFUL! Heart

Hugs, Susan

Mets to brain, lung, liver, eye, femur bone. 1/6/22 started on ARX788 trial. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy: Left, Right; Lymph node removal: Right, Sentinel; Reconstruction (right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy: Right Dx 3/29/2014, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External: Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External: Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External: Brain Immunotherapy 10/25/2019 Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Hormonal Therapy 3/12/2021 Aromasin (exemestane) Targeted Therapy 3/16/2021 Verzenio Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Radiation Therapy 12/21/2021 External: Bone Targeted Therapy 1/6/2022
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Nov 14, 2021 04:32PM Cure-ious wrote:

Wow, give this some thought...

https://medicalxpress.com/news/2021-11-advanced-br...

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Nov 15, 2021 08:28AM Moissy wrote:

That’s great news, Dee! So happy for you

Dx 2004, IDC, 6cm+, Grade 2, 0/1 nodes, ER+, HER2- Dx 2015, Stage IV, ER+/PR+, HER2-
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Nov 15, 2021 08:32AM BevJen wrote:

Dee,

It sounds like you have a great advocate in your Dr. Hamilton who is looking out for you. Your reasoning behind the second SERD seems very sound. Fingers crossed that you get into that trial and that it works for you.

Microwave Ablations,Liver 3x ;Radiation Therapy to Femur (Both) April 2021; total hip replacement (R) and placement of rod (L) to stabilize femur both sides; immunotherapy (single agent - keytruda) Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Keytruda (pembrolizumab) Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Femara (letrozole) Radiation Therapy
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Nov 15, 2021 09:19AM Grannax2 wrote:

Awesome, Dee. Keep us posted.

I just found out that none of my labs will disqualify me. Yay. Also the scheduler for BX should call today. They don’t have my CTs back yet, though.

One step closer.

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Nov 15, 2021 09:39AM BevJen wrote:

Grannax,

Fingers crossed for you, too, that this works out.

Microwave Ablations,Liver 3x ;Radiation Therapy to Femur (Both) April 2021; total hip replacement (R) and placement of rod (L) to stabilize femur both sides; immunotherapy (single agent - keytruda) Dx 11/2003, ILC, Left, Stage IIIC, 13/18 nodes, ER+/PR+, HER2- Dx 6/2006, ILC, Stage IV, metastasized to other, ER+, HER2- Dx 5/2019, ILC, Stage IV, metastasized to liver, ER+/PR+, HER2- Surgery 7/5/2019 Targeted Therapy 7/31/2019 Ibrance (palbociclib) Immunotherapy Keytruda (pembrolizumab) Surgery Lymph node removal: Left, Sentinel; Mastectomy: Left, Right; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Chemotherapy TAC Hormonal Therapy Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Surgery Lymph node removal; Mastectomy; Reconstruction (left): Pedicled TRAM flap; Reconstruction (right): Pedicled TRAM flap Hormonal Therapy Faslodex (fulvestrant) Hormonal Therapy Femara (letrozole) Radiation Therapy
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Nov 15, 2021 10:16AM moth wrote:

dee, great news!

grannax2, fingers crossed for the scans!

I take weekends off

Initial dx at 50. Seriously?? “Sometimes the future changes quickly and completely and we’re left with only the choice of what to do next." blog: Never Tell Me the Odds

Dx 12/2017, IDC, Left, 1cm, Stage IA, Grade 3, 0/5 nodes, ER-/PR-, HER2- (IHC) Surgery 12/12/2017 Lumpectomy: Left; Lymph node removal: Sentinel Chemotherapy 2/14/2018 AC + T (Taxol) Radiation Therapy 8/13/2018 Whole-breast: Breast Dx 2/2020, IDC, Stage IV, metastasized to liver/lungs, Grade 3, ER-/PR-, HER2- Chemotherapy 3/18/2020 Taxol (paclitaxel) Immunotherapy 3/19/2020 Tecentriq (atezolizumab) Chemotherapy 11/26/2020 Abraxane (albumin-bound or nab-paclitaxel) Dx 12/9/2020, IDC, Right, Stage IV, metastasized to lungs, Grade 3, PR-, HER2- (IHC) Radiation Therapy 12/9/2020 External: Chest wall Dx 1/28/2021, IDC, Left, Stage IV, metastasized to bone Radiation Therapy 3/3/2021 External: Bone
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Nov 15, 2021 12:30PM Moissy wrote:

Grannax- Wishing you well on all the qualifications

Dx 2004, IDC, 6cm+, Grade 2, 0/1 nodes, ER+, HER2- Dx 2015, Stage IV, ER+/PR+, HER2-
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Nov 15, 2021 02:08PM Cure-ious wrote:

Dee, How exciting! Your MO probably figures that the cancer found a way to prevent the ARV-471 from degrading ER, we have another drug does the same thing by a different mechanism, you probably can go a long time on that as well!!! Plus, its really helpful for all of us to know that you can be resistant to one but still respond to the other

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Nov 15, 2021 03:01PM NicoleRod wrote:

great news Dee..really happy for you! I really wish I had such a clear leading.... :(

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 15, 2021 04:56PM SusaninSF wrote:

AlabamaDee,

As always, I so appreciate the details you provide about the process you are going through to choose a trial. You are definitely a trailblazer!

I finally got a call from USC. My MO thought they were going to call on Friday so I was a little worried. They scheduled a telemedicine visit for Thursday. So grateful I can do it remotely.

Hugs, Susan

Mets to brain, lung, liver, eye, femur bone. 1/6/22 started on ARX788 trial. Dx 2000, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 8/31/2000 Lumpectomy: Left, Right; Lymph node removal: Right, Sentinel; Reconstruction (right) Dx 2008, DCIS, <1cm, Stage 0, Grade 3, 0/2 nodes, ER+/PR+, HER2- Surgery 3/2/2008 Mastectomy: Right Dx 3/29/2014, Stage IV, metastasized to brain/bone/lungs/other, mets, ER+/PR-, HER2- (FISH) Hormonal Therapy 3/31/2014 Tamoxifen pills (Nolvadex, Apo-Tamox, Tamofen, Tamone) Radiation Therapy 4/28/2014 External: Brain Chemotherapy 10/30/2014 Xeloda (capecitabine) Radiation Therapy 1/8/2015 External: Bone Radiation Therapy 6/6/2016 External Hormonal Therapy 11/16/2016 Faslodex (fulvestrant) Targeted Therapy 12/21/2016 Ibrance (palbociclib) Radiation Therapy 11/27/2017 External: Brain Hormonal Therapy 8/21/2018 Femara (letrozole) Targeted Therapy 8/21/2018 Piqray (alpelisib) Chemotherapy 4/23/2019 Taxol (paclitaxel) Chemotherapy 6/19/2019 Abraxane (albumin-bound or nab-paclitaxel) Radiation Therapy 10/23/2019 External: Brain Immunotherapy 10/25/2019 Targeted Therapy 2/18/2020 Trodelvy (sacituzumab govitecan-hziy) Dx 3/8/2021, Stage IV, metastasized to liver Hormonal Therapy 3/12/2021 Aromasin (exemestane) Targeted Therapy 3/16/2021 Verzenio Chemotherapy 9/8/2021 Carboplatin (Paraplatin), Gemzar (gemcitabine) Chemotherapy 11/2/2021 Halaven (eribulin) Radiation Therapy 12/21/2021 External: Bone Targeted Therapy 1/6/2022
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Nov 15, 2021 11:31PM BSandra wrote:

Good luck Dee, your success is also our success, so... thank you for fighting and helping to push mbc research forward! Saulius

Since May'21:NED. Mar'21:axilla LN surgery. Sep'19-Mar'21:NED. Feb'19:recurrence, left breast,IBC. May'18-Feb'19:NED. Jun'18:DC/CIK. Aug'17:stage IV de novo at age 33. Dx 8/4/2017, IDC, Left, 6cm+, Stage IV, metastasized to liver, Grade 2, ER-/PR-, HER2+ (IHC) Chemotherapy 8/27/2017 Taxotere (docetaxel) Targeted Therapy 8/28/2017 Herceptin (trastuzumab) Targeted Therapy 8/28/2017 Perjeta (pertuzumab) Chemotherapy 3/12/2019 Taxotere (docetaxel) Surgery 7/22/2019 Mastectomy: Left Radiation Therapy 9/9/2019 Whole-breast: Lymph nodes, Chest wall Surgery 4/15/2021 Lymph node removal: Underarm/Axillary Radiation Therapy 12/13/2021 3DCRT: Lymph nodes
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Nov 16, 2021 07:58AM Grannax2 wrote:

Thanks BevJen, moth and Moissy.

I did get my liver BX scheduled for Monday, November 22. One more step in the right direction. Ya

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Nov 16, 2021 09:57AM Simone80 wrote:

Grannax, Dee, and Susan. I'm glad to hear you found some trials. I hope the drugs get you to stable. I look up to all of you in these trials. You're paving the way for others.

Dx 7/2001, IDC, Right, 1cm, Stage IIIA, Grade 3, 7/13 nodes, ER+/PR+, HER2- Dx 1/2019, IDC, 1cm, Stage IV, metastasized to bone/other, ER+/PR+, HER2- (FISH) Targeted Therapy Ibrance (palbociclib) Hormonal Therapy Femara (letrozole)
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Nov 16, 2021 05:13PM NicoleRod wrote:

Anyone see this..especially UK people.... I mean unfortunately we here in the USA probably wont see it to even go to trial for years...let alone be approved..but looks pretty promising...

https://www.express.co.uk/life-style/health/1521058/Cancer-vaccine-latest-NHS-trial

Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right
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Nov 16, 2021 06:13PM Cure-ious wrote:

The producers of Leronlimab (CCR5 monoclonal) have filed with FDA for breakthrough designation, having already received a fastrack, based on a small (28 patients) phase one study and some compasionate use patients, all with TNBC- they find longer PFS and OS for leronlimab and chemo compared to chemo or Trodelvy alone. It would be nice to see leronlimab combined with immunotherapy and tested on additional MBC subtypes.

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Nov 16, 2021 06:22PM - edited Nov 16, 2021 06:23PM by NicoleRod

This Post was deleted by NicoleRod.
Dx 12/14 Stage 0, Grade 3, ER+/PR, HER2- (FISH),Dx 04/19, Stage IV mets to bone/liver, Hormonal Therapy 04/19 - 10/19 Ibrance/let/faslodex 10/19 **TNBC AUG 2021 Dec 2019-May 2020 Xeloda Failed May-July 2020 - Doxil Failed Dx 12/19/2014, DCIS, Right, Stage 0, Grade 3, ER+/PR+, HER2- (FISH) Dx 2/5/2019, IDC, Right, Stage IIA, Grade 3, ER+/PR-, HER2- Dx 3/2019, Stage IV, metastasized to bone/liver, Grade 3, ER+/PR-, HER2- Hormonal Therapy 4/28/2019 Surgery Chemotherapy Doxil (doxorubicin) Chemotherapy Xeloda (capecitabine) Radiation Therapy Surgery Mastectomy: Left, Right

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