ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53, mismatch repair genes (MLH1, MSH2, MSH6, PMS2, EPCAM), and VUS (variants of unknown significance)
These Breastcancer.org links may offer helpful information: All about Genetic Testing: Genetics as a Risk Factor Genetic Testing as part of your Pathology Report What to do with your genetic test results Variants of Unknown Significance (VUS) Learning about your family background Genetic testing facilities and cost…
I was diagnosed with Breast cancer in early July. With in two weeks i was at the COH and a week thereafter I had a genetic test. BRCA2!! Crazy. I notified my family with the letter of my test results and 2 of the four did the test too. They both have BRCA2. I am not sure if one brother got tested, but i hope so. My other…
Good afternoon! I and my daughter both carry the FANCM TNBC gene. I’m a breast cancer survivor who was diagnosed in 2011 at age 43. I had a 1 cm DCIS, Stage 0, Solid/Grade 3 tumor and a subsequent bilateral mastectomy. In 2011, the only recognized breast cancer genes tested were BRCA1 and 2, and TP53 which were obviously…
Hello everyone, I have been diagnosed with Stage 2 BC recently. Got my genetic report yesterday. I have got a finding of BRCA2 Variant of uncertain significance c.9307A>G and MSH6 VUS c.943T>A Anyone with similar mutation? I have a family history of breast cancer in mother and sister. Genetic testing not done in them.…
My idea is that we can use this topic to post our genetic mutation on the off chance that we can find someone else with the same mutation. I realize that this is a long shot because there are so many variations, but what the heck? I tried searching FORCE for mine with no luck. Here's my family's: BRCA2 - 2024del5
Dear Members, Would you be willing to share your story about genetic testing? (no pressure, only if you are inspired!) We are interested in the following questions: What led you to doing the testing? What were your results, and what choices have you made based on the findings? Was payment an issue? How have you discussed…
Lynparza is a PARP inhibitor used to treat breast cancer in people with an inherited BRCA mutation. A small study found that Lynparza could also treat metastatic breast cancer in people with an inherited PALB2 mutation or who have breast cancer that has developed a BRCA mutation over time. This means that many more people…
I had genetic testing done in 2019 and have a ATM variant. I was diagnosed with BC in 2017 (Stage 1 and tumor under 1 CM) and had a lumpectomy followed by radiation treatments. Took the Breast Cancer Index Test and results showed benefit of taking Arimidex for 10 years so I have one more year to go yay. The question I have…
I’m positive for ATM p.N31K, which is classified as a Variant of Unknown Significance (VUS). Does anyone know if science is any closer to being able to determine if this VUS is Likely Benign or Likely Pathogenic? I had bilateral mastectomy with sentinel lobe biopsy about six weeks ago for grade 3 DCIS with comedo necrosis…
Hello everyone. I finished chemo today and now trying to decide between a lumpectomy with radiation or a bilateral mastectomy. I'm seriously thinking about a mastectomy. Would anyone in a similar situation as me be willing to share their feedback on what helped you decide to go for a bilateral mastectomy? How are you…
So I’m wondering how many of us here have the Axin2 gene? I have it with a variant of unknown significance. But my breast cancer surgeon told me years ago that they are learning new stuff all the time, unlearning other stuff and there is still a lot they still don’t know about breast cancer. Just curious how many of us…
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